Telomerase-Independent Paths to Immortality in Predictable Cancer Subtypes

by Stephen T Durant
Published 2012-01-01

Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes.

by Thomas A Ward, Peter J McHugh, Stephen T Durant
Published 2017-01-01

Structures of the human poly (ADP-ribose) glycohydrolase catalytic domain confirm catalytic mechanism and explain inhibition by ADP-HPD derivatives.

by Julie A Tucker, Neil Bennett, Claire Brassington, Stephen T Durant, Giles Hassall, Geoff Holdgate, Mark McAlister, J Willem M Nissink, Caroline Truman, Martin Watson
Published 2012-01-01

ATM kinase inhibitor AZD0156 in combination with irinotecan and 5-fluorouracil in preclinical models of colorectal cancer

by S. Lindsey Davis, Sarah J. Hartman, Stacey M. Bagby, Marina Schlaepfer, Betelehem W. Yacob, Tonia Tse, Dennis M. Simmons, Jennifer R. Diamond, Christopher H. Lieu, Alexis D. Leal, Elaine B. Cadogan, Gareth D. Hughes, Stephen T. Durant, Wells A. Messersmith, Todd M. Pitts
Published 2022-10-01

ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks

by Gabriel Balmus, Domenic Pilger, Julia Coates, Mukerrem Demir, Matylda Sczaniecka-Clift, Ana C. Barros, Michael Woods, Beiyuan Fu, Fengtang Yang, Elisabeth Chen, Matthias Ostermaier, Tatjana Stankovic, Hannes Ponstingl, Mareike Herzog, Kosuke Yusa, Francisco Munoz Martinez, Stephen T. Durant, Yaron Galanty, Petra Beli, David J. Adams, Allan Bradley, Emmanouil Metzakopian, Josep V. Forment, Stephen P. Jackson
Published 2019-01-01

H2AX promotes replication fork degradation and chemosensitivity in BRCA-deficient tumours

by Diego Dibitetto, Martin Liptay, Francesca Vivalda, Hülya Dogan, Ewa Gogola, Martín González Fernández, Alexandra Duarte, Jonas A. Schmid, Morgane Decollogny, Paola Francica, Sara Przetocka, Stephen T. Durant, Josep V. Forment, Ismar Klebic, Myriam Siffert, Roebi de Bruijn, Arne N. Kousholt, Nicole A. Marti, Martina Dettwiler, Claus S. Sørensen, Jean-Christophe Tille, Manuela Undurraga, Intidhar Labidi-Galy, Massimo Lopes, Alessandro A. Sartori, Jos Jonkers, Sven Rottenberg
Published 2024-05-01