Structured Waters Mediate Small Molecule Binding to G-Quadruplex Nucleic Acids

by Stephen Neidle
Published 2021-12-01

The Targeting of Quadruplex Nucleic Acids in Human Cancers

by Stephen Neidle
Published 2019-08-01

A G-Quadruplex-Binding Small Molecule and the HDAC Inhibitor SAHA (Vorinostat) Act Synergistically in Gemcitabine-Sensitive and Resistant Pancreatic Cancer Cells

by Ahmed Abdullah Ahmed, Stephen Neidle
Published 2020-11-01

On Water Arrangements in Right- and Left-Handed DNA Structures

by Liliya A. Yatsunyk, Stephen Neidle
Published 2024-01-01

Xanthene and Xanthone Derivatives as G-Quadruplex Stabilizing Ligands

by Alessandro Altieri, Antonello Alvino, Stephan Ohnmacht, Giancarlo Ortaggi, Stephen Neidle, Daniele Nocioni, Marco Franceschin, Armandodoriano Bianco
Published 2013-10-01

Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors

by Matthias G. J. Baud, Thomas Leiser, Vanessa Petrucci, Mekala Gunaratnam, Stephen Neidle, Franz-Josef Meyer-Almes, Matthew J. Fuchter
Published 2013-01-01

The Potent G-Quadruplex-Binding Compound QN-302 Downregulates S100P Gene Expression in Cells and in an In Vivo Model of Pancreatic Cancer

by Ahmed A. Ahmed, William Greenhalf, Daniel H. Palmer, Nicole Williams, Jenny Worthington, Tariq Arshad, Shozeb Haider, Effrosyni Alexandrou, Dilek Guneri, Zoe A. E. Waller, Stephen Neidle
Published 2023-03-01

Structure–activity relationships for the G-quadruplex-targeting experimental drug QN-302 and two analogues probed with comparative transcriptome profiling and molecular modeling

by Ahmed Abdullah Ahmed, Shuang Chen, Maria Roman-Escorza, Richard Angell, Sally Oxenford, Matthew McConville, Naomi Barton, Mihiro Sunose, Dan Neidle, Shozeb Haider, Tariq Arshad, Stephen Neidle
Published 2024-02-01

Targeting KRAS Oncogene in Colon Cancer Cells with 7-Carboxylate Indolo[3,2-b]quinoline Tri-Alkylamine Derivatives.

by Hugo Brito, Ana Cláudia Martins, João Lavrado, Eduarda Mendes, Ana Paula Francisco, Sofia A Santos, Stephan A Ohnmacht, Nam-Soon Kim, Cecília M P Rodrigues, Rui Moreira, Stephen Neidle, Pedro M Borralho, Alexandra Paulo
Published 2015-01-01

G‐quadruplex‐binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo

by Roberto Simone, Rubika Balendra, Thomas G Moens, Elisavet Preza, Katherine M Wilson, Amanda Heslegrave, Nathan S Woodling, Teresa Niccoli, Javier Gilbert‐Jaramillo, Samir Abdelkarim, Emma L Clayton, Mica Clarke, Marie‐Therese Konrad, Andrew J Nicoll, Jamie S Mitchell, Andrea Calvo, Adriano Chio, Henry Houlden, James M Polke, Mohamed A Ismail, Chad E Stephens, Tam Vo, Abdelbasset A Farahat, W David Wilson, David W Boykin, Henrik Zetterberg, Linda Partridge, Selina Wray, Gary Parkinson, Stephen Neidle, Rickie Patani, Pietro Fratta, Adrian M Isaacs
Published 2018-01-01