CAR T-Cells for the Treatment of B-Cell Acute Lymphoblastic Leukemia

by Khalil Saleh, Florence Pasquier, Camille Bigenwald, Stéphane De Botton, Vincent Ribrag, Cristina Castilla-Llorente
Published 2023-10-01

PB1884: ENGAGING INNATE IMMUNITY: A PHASE 1 DOSE ESCALATION STUDY TO ASSESS SAFETY AND TOLERABILITY OF AFM28 MONOTHERAPY IN PATIENTS WITH RELAPSED/REFRACTORY CD123-POSITIVE ACUTE M...

by Montserrat Arnan, Pau Montesinos, Stéphane de Botton, Christian Recher, Lydia Wunderle, Michael Emig, Andreas Harstrick, Kerstin Pietzko, Sheena Pinto, Paulien Ravenstijn, Naval Daver
Published 2023-08-01

Chromosomal minimal critical regions in therapy-related leukemia appear different from those of de novo leukemia by high-resolution aCGH.

by Nathalie Itzhar, Philippe Dessen, Saloua Toujani, Nathalie Auger, Claude Preudhomme, Catherine Richon, Vladimir Lazar, Véronique Saada, Anelyse Bennaceur, Jean Henri Bourhis, Stéphane de Botton, Alain Bernheim
Published 2011-02-01

CDKN1A is a target for phagocytosis-mediated cellular immunotherapy in acute leukemia

by Awatef Allouch, Laurent Voisin, Yanyan Zhang, Syed Qasim Raza, Yann Lecluse, Julien Calvo, Dorothée Selimoglu-Buet, Stéphane de Botton, Fawzia Louache, Françoise Pflumio, Eric Solary, Jean-Luc Perfettini
Published 2022-11-01

Targeting primary acute myeloid leukemia with a new CXCR4 antagonist IgG1 antibody (PF-06747143)

by Yanyan Zhang, Erika Saavedra, Ruoping Tang, Yin Gu, Patrick Lappin, Dusko Trajkovic, Shu-Hui Liu, Tod Smeal, Valeria Fantin, Stephane De Botton, Ollivier Legrand, Francois Delhommeau, Flavia Pernasetti, Fawzia Louache
Published 2017-08-01

P490: UPDATED SURVIVAL, BLOOD COUNT RECOVERY AND SAFETY RESULTS FROM THE AGILE STUDY IN PATIENTS WITH ACUTE MYELOID LEUKEMIA TREATED WITH IVOSIDENIB + AZACITIDINE COMPARED TO PLACE...

by Hartmut Döhner, Pau Montesinos, Susana Vives Polo, Ewa Zarzycka, Jianxiang Wang, Marta Riva, Michael Heuser, Rodrigo Calado, Andre Schuh, Su-Peng Yeh, Jianan Hui, Diego Gianolio, Prapti A Patel, Christian Recher, Stephane de Botton
Published 2023-08-01

Impact of additional genetic alterations on the outcome of patients with NPM1-mutated cytogenetically normal acute myeloid leukemia

by Pierre Peterlin, Aline Renneville, Raouf Ben Abdelali, Olivier Nibourel, Xavier Thomas, Cécile Pautas, Stéphane de Botton, Emmanuel Raffoux, Jean-Michel Cayuela, Nicolas Boissel, Christine Terré, Karine Celli-Lebras, Sylvie Castaigne, Claude Preudhomme, Claude Gardin, Hervé Dombret
Published 2015-05-01

Clinical Significance of ABCB1 in Acute Myeloid Leukemia: A Comprehensive Study

by Thomas Boyer, Fanny Gonzales, Adeline Barthélémy, Alice Marceau-Renaut, Pauline Peyrouze, Soizic Guihard, Pascale Lepelley, Adriana Plesa, Olivier Nibourel, Carole Delattre, Marc Wetterwald, Nicolas Pottier, Isabelle Plantier, Stéphane de Botton, Hervé Dombret, Céline Berthon, Claude Preudhomme, Christophe Roumier, Meyling Cheok
Published 2019-09-01

Germline RUNX1 Intragenic Deletion: Implications for Accurate Diagnosis of FPD/AML

by Nicolas Duployez, Jean-Edouard Martin, Sabine Khalife-Hachem, Ryane Benkhelil, Véronique Saada, Christophe Marzac, Nathalie Auger, Alice Marceau-Renaut, Rémi Favier, Paola Ballerini, Olivier Caron, André Baruchel, Stéphane de Botton, Claude Preudhomme, Jean-Baptiste Micol, Hana Raslova, Iléana Antony-Debré
Published 2019-06-01

Arsenic trioxide is required in the treatment of newly diagnosed acute promyelocytic leukemia. Analysis of a randomized trial (APL 2006) by the French Belgian Swiss APL group

by Lionel Adès, Xavier Thomas, Agnes Guerci Bresler, Emmanuel Raffoux, Olivier Spertini, Norbert Vey, Tony Marchand, Christian Récher, Arnaud Pigneux, Stephane Girault, Eric Deconinck, Claude Gardin, Olivier Tournilhac, Jean Francois Lambert, Patrice Chevallier, Stephane de Botton, Julie Lejeune, Hervé Dombret, Sylvie Chevret, Pierre Fenaux
Published 2018-12-01

P724: UPDATED SUBSTUDY RESULTS FOR IVOSIDENIB IN IDH1-MUTANT RELAPSED/REFRACTORY MYELODYSPLASTIC SYNDROME

by Courtney Dinardo, Gail Roboz, Justin M. Watts, Yazan Madanat, Gabrielle T Prince, Praneeth Baratam, Stéphane de Botton, Anthony Stein, James M Foran, Martha L Arellano, David Sallman, Dylan M Marchione, Xiaofei Bai, Prapti A Patel, Stephanie M Kapsalis, Guillermo Garcia-Manero, Amir Fathi
Published 2023-08-01

Minimal residual disease monitoring in acute myeloid leukemia with non-A/B/D-NPM1 mutations by digital polymerase chain reaction: feasibility and clinical use

by Auriane Lesieur, Xavier Thomas, Olivier Nibourel, Nicolas Boissel, Laurène Fenwarth, Stéphane De Botton, Elise Fournier, Karine Celli-Lebras, Emmanuel Raffoux, Christian Recher, Juliette Lambert, Céline Berthon, Arnaud Pigneux, Raphael Itzykson, Pascal Turlure, Cécile Pautas, Jacques Vargaftig, Claude Preudhomme, Hervé Dombret, Nicolas Duployez
Published 2020-12-01

PB1773: AML AND MDS WITH RARA OVEREXPRESSION: MOLECULAR AND CLINICAL FEATURES OF PATIENTS ENROLLED IN A PHASE 2 TRIAL EVALUATING TAMIBAROTENE-BASED THERAPY

by Stéphane de Botton, Thomas Cluzeau, Carlos Vigil, Rachel Cook, Philippe Rousselot, David Rizzieri, Jane Liesveld, Pierre Fenaux, Thorsten Braun, Arnaud Pigneux, Pierre Peterlin, Sofia Paul, Nisha Rajagopal, John Carulli, David Roth, Angela Volkert, Tanya Abdul Malak, Michael Kelly, Virginia Klimek, Eytan Stein
Published 2023-08-01

TET2 gene mutation is a frequent and adverse event in chronic myelomonocytic leukemia

by Olivier Kosmider, Véronique Gelsi-Boyer, Marion Ciudad, Cindy Racoeur, Valérie Jooste, Norbert Vey, Bruno Quesnel, Pierre Fenaux, Jean-Noël Bastie, Odile Beyne-Rauzy, Aspasia Stamatoulas, François Dreyfus, Norbert Ifrah, Stéphane de Botton, William Vainchenker, Oliver A. Bernard, Daniel Birnbaum, Michaëla Fontenay, Eric Solary
Published 2009-12-01

When monoclonal gammopathy‐associated chronic neutrophilic leukemia is a reactive process distinct from a clonal myeloproliferative neoplasm: Lessons from mistakes

by Christophe Willekens, Claude Chahine, Matteo Dragani, Sabine Khalife‐Hachem, Camille Bigenwald, Julien Rossignol, Cristina Castilla‐Llorente, Alina Danu, Jean‐Marie Michot, Veronique Saada, Sophie Cotteret, Christophe Marzac, Aline Renneville, Isabelle Plo, Sophie Broutin, Nelly Bosselut, Bruno Cassinat, Julien Lazarovici, Nathalie Droin, Stephane De Botton
Published 2023-08-01

P494: A FIRST-IN-HUMAN STUDY OF CD123 NK CELL ENGAGER SAR443579 IN RELAPSED OR REFRACTORY ACUTE MYELOID LEUKEMIA, B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA OR HIGH RISK-MYELODYSPLASIA

by Anthony Selwyn Stein, Mojca Jongen-Lavrencic, Sylvain Garciaz, Gerwin A Huls, Abhishek Maiti, Nicolas Boissel, Stephane De Botton, Shaun Fleming, C. Michel Zwaan, David C. de Leeuw, Pinkal Desai, Martha Lucia Arellano, David Avigan, Saskia Langemeijer, Kyle Jensen, Timothy Wagenaar, Gu MI, Giovanni Abbadessa, Ashish Bajel
Published 2023-08-01

Molecular Landscape of Therapy-related Myeloid Neoplasms in Patients Previously Treated for Gynecologic and Breast Cancers

by Sabine Khalife-Hachem, Khalil Saleh, Florence Pasquier, Christophe Willekens, Anthony Tarabay, Leony Antoun, Thomas Grinda, Cristina Castilla-Llorente, Matthieu Duchmann, Cyril Quivoron, Nathalie Auger, Veronique Saada, Suzette Delaloge, Alexandra Leary, Aline Renneville, Ileana Antony-Debre, Filippo Rosselli, Stéphane De Botton, Flore Salviat, Christophe Marzac, Jean-Baptiste Micol
Published 2021-09-01

Improved survival with enasidenib versus standard of care in relapsed/refractory acute myeloid leukemia associated with IDH2 mutations using historical data and propensity score ma...

by Stéphane deBotton, Joseph M. Brandwein, Andrew H. Wei, Arnaud Pigneux, Bruno Quesnel, Xavier Thomas, Ollivier Legrand, Christian Recher, Sylvain Chantepie, Mathilde Hunault‐Berger, Nicolas Boissel, Salem A. Nehme, Mark G. Frattini, Alessandra Tosolini, Roland Marion‐Gallois, Jixian J. Wang, Chris Cameron, Muhaimen Siddiqui, Brian Hutton, Gary Milkovich, Eytan M. Stein
Published 2021-09-01

Impact and consequences of intensive chemotherapy on intestinal barrier and microbiota in acute myeloid leukemia: the role of mucosal strengthening

by Thomas Hueso, Kenneth Ekpe, Camille Mayeur, Anna Gatse, Marie Joncquel-Chevallier Curt, Guillaume Gricourt, Christophe Rodriguez, Charles Burdet, Guillaume Ulmann, Christel Neut, Salah-Eddine Amini, Patricia Lepage, Bruno Raynard, Christophe Willekens, Jean-Baptiste Micol, Stéphane De Botton, Ibrahim Yakoub-Agha, Frédéric Gottrand, Jean-Luc Desseyn, Muriel Thomas, Paul-Louis Woerther, David Seguy
Published 2020-11-01

P504: UPDATED DATA FOR ZIFTOMENIB IN PATIENTS WITH NPM1-MUTATED RELAPSED OR REFRACTORY ACUTE MYELOID LEUKEMIA

by Amir Fathi, Eunice Wang, Ghayas Issa, Jessica Altman, Pau Montesinos, Stéphane de Botton, Roland Walter, Kirsten Pettit, Mrinal Patnaik, Marina Kremyanskaya, Maria Baer, James M Foran, Gary Schiller, Lionel Ades, Maël Heiblig, Pierre Peterlin, Olga Salamero Garcia, Cristina Papayannidis, Kun Nie, Julie Ahsan Mackey, Marilyn Tabachri, Daniel Corum, Mollie Leoni, Stephen Dale, Harry Erba
Published 2023-08-01