GSK-3β Allosteric Inhibition: A Dead End or a New Pharmacological Frontier?

by Beatrice Balboni, Mirco Masi, Walter Rocchia, Stefania Girotto, Andrea Cavalli
Published 2023-04-01

Novel Insights into RAD52’s Structure, Function, and Druggability for Synthetic Lethality and Innovative Anticancer Therapies

by Beatrice Balboni, Francesco Rinaldi, Viola Previtali, Andrea Ciamarone, Stefania Girotto, Andrea Cavalli
Published 2023-03-01

SOD1 and amyotrophic lateral sclerosis: mutations and oligomerization.

by Lucia Banci, Ivano Bertini, Mirela Boca, Stefania Girotto, Manuele Martinelli, Joan Selverstone Valentine, Miguela Vieru
Published 2008-02-01

Keys to Lipid Selection in Fatty Acid Amide Hydrolase Catalysis: Structural Flexibility, Gating Residues and Multiple Binding Pockets.

by Giulia Palermo, Inga Bauer, Pablo Campomanes, Andrea Cavalli, Andrea Armirotti, Stefania Girotto, Ursula Rothlisberger, Marco De Vivo
Published 2015-06-01

Identification of Novel GSK-3β Hits Using Competitive Biophysical Assays

by Beatrice Balboni, Shailesh Kumar Tripathi, Marina Veronesi, Debora Russo, Ilaria Penna, Barbara Giabbai, Tiziano Bandiera, Paola Storici, Stefania Girotto, Andrea Cavalli
Published 2022-03-01

The Mechanistic Understanding of RAD51 Defibrillation: A Critical Step in BRCA2-Mediated DNA Repair by Homologous Recombination

by Fabrizio Schipani, Marcella Manerba, Roberto Marotta, Laura Poppi, Arianna Gennari, Francesco Rinaldi, Andrea Armirotti, Fulvia Farabegoli, Marinella Roberti, Giuseppina Di Stefano, Walter Rocchia, Stefania Girotto, Nicola Tirelli, Andrea Cavalli
Published 2022-07-01

Chloride intracellular channel 1 activity is not required for glioblastoma development but its inhibition dictates glioma stem cell responsivity to novel biguanide derivatives

by Federica Barbieri, Alessia Graziana Bosio, Alessandra Pattarozzi, Michele Tonelli, Adriana Bajetto, Ivan Verduci, Francesca Cianci, Gaetano Cannavale, Luca M. G. Palloni, Valeria Francesconi, Stefano Thellung, Pietro Fiaschi, Samanta Mazzetti, Silvia Schenone, Beatrice Balboni, Stefania Girotto, Paolo Malatesta, Antonio Daga, Gianluigi Zona, Michele Mazzanti, Tullio Florio
Published 2022-02-01