Machine-learning analysis of intrinsically disordered proteins identifies key factors that contribute to neurodegeneration-related aggregation

by Akshatha Ganne, Meenakshisundaram Balasubramaniam, Srinivas Ayyadevara, Srinivas Ayyadevara, Srinivas Ayyadevara, Robert J. Shmookler Reis, Robert J. Shmookler Reis, Robert J. Shmookler Reis
Published 2022-08-01

Positive feedback between transcriptional and kinase suppression in nematodes with extraordinary longevity and stress resistance.

by Cagdaş Tazearslan, Srinivas Ayyadevara, Puneet Bharill, Robert J Shmookler Reis
Published 2009-04-01

Glial Fibrillary Acidic Protein: A Biomarker and Drug Target for Alzheimer’s Disease

by Akshatha Ganne, Meenakshisundaram Balasubramaniam, W. Sue T. Griffin, Robert J. Shmookler Reis, Srinivas Ayyadevara
Published 2022-06-01

Physiological Consequences of Targeting 14-3-3 and Its Interacting Partners in Neurodegenerative Diseases

by Akshatha Ganne, Meenakshisundaram Balasubramaniam, Nirjal Mainali, Paavan Atluri, Robert J. Shmookler Reis, Srinivas Ayyadevara
Published 2022-12-01

Alzheimer’s-specific brain amyloid interactome: Neural-network analysis of intra-aggregate crosslinking identifies novel drug targets

by Meenakshisundaram Balasubramaniam, Akshatha Ganne, Nirjal Mainali, Sonu Pahal, Srinivas Ayyadevara, Robert J. Shmookler Reis
Published 2024-01-01

Label-free photothermal disruption of cytotoxic aggregates rescues pathology in a C. elegans model of Huntington’s disease

by Dmitry A. Nedosekin, TsungYen Chen, Srinivas Ayyadevara, Vladimir P. Zharov, Robert J. Shmookler Reis
Published 2021-10-01

Proteomic analysis of transcription factors involved in the alteration of ischemic mouse heart as modulated by MSC exosomes

by Rajshekhar A. Kore, Samir V. Jenkins, Azemat Jamshidi-Parsian, Alan J. Tackett, Robert J. Griffin, Srinivas Ayyadevara, Jawahar L. Mehta
Published 2023-07-01

Design and Synthesis of Novel Hybrid 8-Hydroxy Quinoline-Indole Derivatives as Inhibitors of Aβ Self-Aggregation and Metal Chelation-Induced Aβ Aggregation

by Suresh K. Bowroju, Nirjal Mainali, Srinivas Ayyadevara, Narsimha R. Penthala, Sesha Krishnamachari, Samuel Kakraba, Robert J. Shmookler Reis, Peter A. Crooks
Published 2020-08-01

Aggregate Interactome Based on Protein Cross-linking Interfaces Predicts Drug Targets to Limit Aggregation in Neurodegenerative Diseases

by Meenakshisundaram Balasubramaniam, Srinivas Ayyadevara, Akshatha Ganne, Samuel Kakraba, Narsimha Reddy Penthala, Xiuxia Du, Peter A. Crooks, Sue T. Griffin, Robert J. Shmookler Reis
Published 2019-10-01

A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer’s Disease

by Samuel Kakraba, Srinivas Ayyadevara, Srinivas Ayyadevara, Narsimha Reddy Penthala, Meenakshisundaram Balasubramaniam, Akshatha Ganne, Ling Liu, Ramani Alla, Ramani Alla, Shoban Babu Bommagani, Steven W. Barger, Steven W. Barger, W. Sue T. Griffin, W. Sue T. Griffin, Peter A. Crooks, Robert J. Shmookler Reis, Robert J. Shmookler Reis, Robert J. Shmookler Reis
Published 2019-12-01

Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules

by Meenakshisundaram Balasubramaniam, Jagadeesh Narasimhappagari, Ling Liu, Akshatha Ganne, Srinivas Ayyadevara, Ramani Atluri, Haarika Ayyadevara, Guy Caldwell, Robert J. Shmookler Reis, Steven W. Barger, W. Sue T. Griffin
Published 2024-01-01

Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend <i>C. elegans</i> Life- and Healthspan

by Samuel Kakraba, Srinivas Ayyadevara, Nirjal Mainali, Meenakshisundaram Balasubramaniam, Suresh Bowroju, Narsimha Reddy Penthala, Ramani Atluri, Steven W. Barger, Sue T. Griffin, Peter A. Crooks, Robert J. Shmookler Reis
Published 2023-10-01