A Case of Adult-Onset Still’s Disease Caused by a Novel Splicing Mutation in TNFAIP3 Successfully Treated With Tocilizumab

by Dylan Lawless, Shelly Pathak, Thomas Edward Scambler, Lylia Ouboussad, Rashida Anwar, Sinisa Savic, Sinisa Savic
Published 2018-07-01

Inositol-Requiring Enzyme 1-Mediated Downregulation of MicroRNA (miR)-146a and miR-155 in Primary Dermal Fibroblasts across Three TNFRSF1A Mutations Results in Hyperresponsiveness...

by Stephanie R. Harrison, Thomas Scambler, Lylia Oubussad, Chi Wong, Miriam Wittmann, Miriam Wittmann, Miriam Wittmann, Michael F. McDermott, Sinisa Savic, Sinisa Savic, Sinisa Savic
Published 2018-02-01

The Scope and Impact of Viral Infections in Common Variable Immunodeficiency (CVID) and CVID-like Disorders: A Literature Review

by Adam Al-Hakim, Mark Kacar, Sinisa Savic
Published 2024-03-01

Glucose-6-Phosphatase Catalytic Subunit 3 (G6PC3) Deficiency Associated With Autoinflammatory Complications

by Anoop Mistry, Thomas Scambler, David Parry, Mark Wood, Gabriela Barcenas-Morales, Clive Carter, Rainer Doffinger, Sinisa Savic, Sinisa Savic
Published 2017-11-01

Long term management of patients with cryopyrin-associated periodic syndromes (CAPS): focus on rilonacept (IL-1 Trap)

by Leigh D Church, Sinisa Savic, Michael F McDermott
Published 2008-10-01

A Personalized Rituximab Retreatment Approach Based on Clinical and B-Cell Biomarkers in ANCA-Associated Vasculitis

by Jack Arnold, Edward M. Vital, Edward M. Vital, Shouvik Dass, Shouvik Dass, Aamir Aslam, Aamir Aslam, Andy C. Rawstron, Sinisa Savic, Sinisa Savic, Paul Emery, Paul Emery, Md Yuzaiful Md Yusof, Md Yuzaiful Md Yusof
Published 2022-01-01

Somatic Mutations and the Risk of Undifferentiated Autoinflammatory Disease in MDS: An Under-Recognized but Prognostically Important Complication

by Abdulla Watad, Abdulla Watad, Mark Kacar, Mark Kacar, Nicola Luigi Bragazzi, Qiao Zhou, Qiao Zhou, Miriam Jassam, Jan Taylor, Eve Roman, Alexandra Smith, Richard A. Jones, Howard Amital, Catherine Cargo, Dennis McGonagle, Sinisa Savic, Sinisa Savic
Published 2021-02-01

Metabolic Reprograming of Cystic Fibrosis Macrophages via the IRE1α Arm of the Unfolded Protein Response Results in Exacerbated Inflammation

by Samuel Lara-Reyna, Samuel Lara-Reyna, Samuel Lara-Reyna, Thomas Scambler, Thomas Scambler, Jonathan Holbrook, Jonathan Holbrook, Jonathan Holbrook, Chi Wong, Chi Wong, Chi Wong, Heledd H. Jarosz-Griffiths, Heledd H. Jarosz-Griffiths, Heledd H. Jarosz-Griffiths, Fabio Martinon, Fabio Martinon, Sinisa Savic, Sinisa Savic, Sinisa Savic, Daniel Peckham, Daniel Peckham, Daniel Peckham, Michael F. McDermott, Michael F. McDermott
Published 2019-08-01

Management of penicillin allergy in primary care: a qualitative study with patients and primary care physicians

by Marta Wanat, Sibyl Anthierens, Christopher C. Butler, Louise Savic, Sinisa Savic, Sue H. Pavitt, Jonathan A. T. Sandoe, Sarah Tonkin-Crine
Published 2021-06-01

Evidence of B Cell Clonality and Investigation Into Properties of the IgM in Patients With Schnitzler Syndrome

by Shelly Pathak, Dorota Rowczenio, Samuel Lara-Reyna, Mark Kacar, Roger Owen, Gina Doody, Karoline Krause, Helen Lachmann, Rainer Doffinger, Darren Newton, Sinisa Savic
Published 2020-12-01

Anti-inflammatory effects of elexacaftor/tezacaftor/ivacaftor in adults with cystic fibrosis heterozygous for F508del.

by Heledd H Jarosz-Griffiths, Lindsey Gillgrass, Laura R Caley, Giulia Spoletini, Ian J Clifton, Christine Etherington, Sinisa Savic, Michael F McDermott, Daniel Peckham
Published 2024-01-01

Anti-inflammatory effects of elexacaftor/tezacaftor/ivacaftor in adults with cystic fibrosis heterozygous for F508del

by Heledd H. Jarosz-Griffiths, Lindsey Gillgrass, Laura R. Caley, Giulia Spoletini, Ian J. Clifton, Christine Etherington, Sinisa Savic, Michael F. McDermott, Daniel Peckham
Published 2024-01-01

ENaC-mediated sodium influx exacerbates NLRP3-dependent inflammation in cystic fibrosis

by Thomas Scambler, Heledd H Jarosz-Griffiths, Samuel Lara-Reyna, Shelly Pathak, Chi Wong, Jonathan Holbrook, Fabio Martinon, Sinisa Savic, Daniel Peckham, Michael F McDermott
Published 2019-09-01

Biallelic mutations in calcium release activated channel regulator 2A (CRACR2A) cause a primary immunodeficiency disorder

by Beibei Wu, Laura Rice, Jennifer Shrimpton, Dylan Lawless, Kieran Walker, Clive Carter, Lynn McKeown, Rashida Anwar, Gina M Doody, Sonal Srikanth, Yousang Gwack, Sinisa Savic
Published 2021-12-01

Recovery of Bone Marrow Function in VEXAS Syndrome-potential Role for Romiplostim

by Adam Al-Hakim, Alyssa Cull, Joanna Topping, Fatima Nadat, Joanna Milek, Razan Alhefzi, Michael F. McDermott, Roger Owen, Catherine Cargo, James Poulter, David G. Kent, Sinisa Savic, on behalf of the ImmunAID consortium*
Published 2023-08-01

Arthritis in Two Patients With Partial Recombination Activating Gene Deficiency

by Kevin Y. Wu, Pooja Purswani, Boglarka Ujhazi, Krisztian Csomos, Mihailova Snezhina, Naumova Elissaveta, Stefan Stefanov, Svetlana Sharapova, Maryssa Ellison, Diana Milojevic, Sinisa Savic, Ravishankar Sargur, Ravishankar Sargur, Jolan E. Walter, Jolan E. Walter
Published 2019-07-01

Different CFTR modulator combinations downregulate inflammation differently in cystic fibrosis

by Heledd H Jarosz-Griffiths, Thomas Scambler, Chi H Wong, Samuel Lara-Reyna, Jonathan Holbrook, Fabio Martinon, Sinisa Savic, Paul Whitaker, Christine Etherington, Giulia Spoletini, Ian Clifton, Anil Mehta, Michael F McDermott, Daniel Peckham
Published 2020-03-01

Combined Immunodeficiency With Late-Onset Progressive Hypogammaglobulinemia and Normal B Cell Count in a Patient With RAG2 Deficiency

by Mayra B. Dorna, Pamela F. A. Barbosa, Andréia Rangel-Santos, Krisztian Csomos, Boglarka Ujhazi, Joseph F. Dasso, Joseph F. Dasso, Daniel Thwaites, Joan Boyes, Sinisa Savic, Jolan E. Walter, Jolan E. Walter, Jolan E. Walter
Published 2019-04-01

Late-Onset Cryopyrin-Associated Periodic Syndromes Caused by Somatic NLRP3 Mosaicism—UK Single Center Experience

by Dorota M. Rowczenio, Sónia Melo Gomes, Juan I. Aróstegui, Anna Mensa-Vilaro, Ebun Omoyinmi, Hadija Trojer, Anna Baginska, Alberto Baroja-Mazo, Pablo Pelegrin, Sinisa Savic, Thirusha Lane, Rene Williams, Paul Brogan, Helen J. Lachmann, Philip N. Hawkins
Published 2017-10-01

Managing Penicillin Allergy in Primary Care: An Important but Neglected Aspect of Antibiotic Stewardship

by Marta Wanat, Sibyl Anthierens, Marta Santillo, Catherine Porter, Joanne Fielding, Mina Davoudianfar, Emily Bongard, Ly-Mee Yu, Christopher Butler, Louise Savic, Sinisa Savic, Johanna Cook, Kelsey Armitage, Philip Howard, Sue Pavitt, Jonathan A. T. Sandoe, Sarah Tonkin-Crine
Published 2023-03-01