Comparison of Bayesian and frequentist group-sequential clinical trial designs

by Nigel Stallard, Susan Todd, Elizabeth G. Ryan, Simon Gates
Published 2020-01-01

Do we need to adjust for interim analyses in a Bayesian adaptive trial design?

by Elizabeth G. Ryan, Kristian Brock, Simon Gates, Daniel Slade
Published 2020-06-01

Bayesian adaptive designs for multi-arm trials: an orthopaedic case study

by Elizabeth G. Ryan, Sarah E. Lamb, Esther Williamson, Simon Gates
Published 2020-01-01

Bayesian group sequential designs for phase III emergency medicine trials: a case study using the PARAMEDIC2 trial

by Elizabeth G. Ryan, Nigel Stallard, Ranjit Lall, Chen Ji, Gavin D. Perkins, Simon Gates
Published 2020-01-01

Clinical Trials in High-Risk Medulloblastoma: Evolution of the SIOP-Europe HR-MB Trial

by Simon Bailey, Nicolas André, Lorenza Gandola, Maura Massimino, Keith Wheatley, Simon Gates, Victoria Homer, Stefan Rutkowski, Steven C. Clifford
Published 2022-01-01

Correction: Bailey et al. Clinical Trials in High-Risk Medulloblastoma: Evolution of the SIOP-Europe HR-MB Trial. <i>Cancers</i> 2022, <i>14</i>, 374

by Simon Bailey, Nicolas André, Lorenza Gandola, Maura Massimino, Keith Wheatley, Simon Gates, Victoria Homer, Stefan Rutkowski, Steven C. Clifford
Published 2024-03-01

Using Bayesian adaptive designs to improve phase III trials: a respiratory care example

by Elizabeth G. Ryan, Julie Bruce, Andrew J. Metcalfe, Nigel Stallard, Sarah E. Lamb, Kert Viele, Duncan Young, Simon Gates
Published 2019-05-01

Rapid detection of health-care-associated bloodstream infection in critical care using multipathogen real-time polymerase chain reaction technology: a diagnostic accuracy study and...

by Geoffrey Warhurst, Graham Dunn, Paul Chadwick, Bronagh Blackwood, Daniel McAuley, Gavin D Perkins, Ronan McMullan, Simon Gates, Andrew Bentley, Duncan Young, Gordon L Carlson, Paul Dark
Published 2015-05-01

Research Priorities for Pediatric Intensive Care Nutrition Within the United Kingdom: A National Institute of Health Research James Lind Alliance Priority Setting Partnership

by Graeme O’Connor, RD, PHD, Luise V. Marino, RD, PHD, Lyvonne N. Tume, RN, PHD, Alexandra Stewart, RCSLT, Simon Gates, BSC, Julie Lanigan, RD, PHD, Harish Bangalore, MBBS, MRCPCh, Suzannah Kinsella, BSC
Published 2022-03-01

CATALYST trial protocol: a multicentre, open-label, phase II, multiarm trial for an early and accelerated evaluation of the potential treatments for COVID-19 in hospitalised adults

by Dhruv Parekh, Simon Gates, Julian Bion, Tonny Veenith, Matthew Rowland, Anna Rowe, Pamela Kearns, Benjamin A. Fisher, Daniel Slade, Rowena Sharpe, David R. Thickett, James Scriven, Sarah J. Bowden, Joshua S. Savage, Duncan Richards
Published 2021-11-01

Protocol for a randomised controlled trial of Subacromial spacer for Tears Affecting Rotator cuff Tendons: a Randomised, Efficient, Adaptive Clinical Trial in Surgery (START:REACTS...

by Martin Underwood, Nicholas Parsons, Helen Parsons, Jaclyn Brown, James Mason, Simon Gates, Andrew Metcalfe, Elke Gemperle Mannion, Josephine Fox, Rebecca Kearney, Tom Lawrence, Howard Bush, Kerri McGowan, Iftekhar Khan, Charles Hutchinson, Nigel Stallard, Stephen Drew
Published 2020-05-01

Cost-effectiveness of adrenaline for out-of-hospital cardiac arrest

by Felix Achana, Stavros Petrou, Jason Madan, Kamran Khan, Chen Ji, Anower Hossain, Ranjit Lall, Anne-Marie Slowther, Charles D. Deakin, Tom Quinn, Jerry P. Nolan, Helen Pocock, Nigel Rees, Michael Smyth, Simon Gates, Dale Gardiner, Gavin D. Perkins, for the PARAMEDIC2 Collaborators
Published 2020-09-01

Induction of labour for predicted macrosomia: study protocol for the ‘Big Baby’ randomised controlled trial

by Martin Underwood, Sara Wood, Stavros Petrou, Jaclyn Brown, Simon Gates, Ceri Jones, Mandy Williams, Hema Mistry, Anne-Marie Slowther, Katie Booth, Ranjit Lall, Debra Bick, Siobhan Quenby, SANJEEV DESHPANDE, Joanne D Fisher, Jason Gardosi, Adam Gornall, Adrian Willis, Lauren Jade Ewington, Ryan Griffin, Kirsten Harris, Emily Butler, Kelly Fowler, Jackie Dewdney, Karen Hillyer
Published 2022-11-01

Protocolised non-invasive compared with invasive weaning from mechanical ventilation for adults in intensive care: the Breathe RCT

by Gavin D Perkins, Dipesh Mistry, Ranjit Lall, Fang Gao-Smith, Catherine Snelson, Nicholas Hart, Luigi Camporota, James Varley, Coralie Carle, Elankumaran Paramasivam, Beverly Hoddell, Adam de Paeztron, Sukhdeep Dosanjh, Julia Sampson, Laura Blair, Keith Couper, Daniel McAuley, J Duncan Young, Tim Walsh, Bronagh Blackwood, Louise Rose, Sarah E Lamb, Melina Dritsaki, Mandy Maredza, Iftekhar Khan, Stavros Petrou, Simon Gates
Published 2019-09-01

Prehospital randomised assessment of a mechanical compression device in out-of-hospital cardiac arrest (PARAMEDIC): a pragmatic, cluster randomised trial and economic evaluation

by Simon Gates, Ranjit Lall, Tom Quinn, Charles D Deakin, Matthew W Cooke, Jessica Horton, Sarah E Lamb, Anne-Marie Slowther, Malcolm Woollard, Andy Carson, Mike Smyth, Kate Wilson, Garry Parcell, Andrew Rosser, Richard Whitfield, Amanda Williams, Rebecca Jones, Helen Pocock, Nicola Brock, John JM Black, John Wright, Kyee Han, Gary Shaw, Laura Blair, Joachim Marti, Claire Hulme, Christopher McCabe, Silviya Nikolova, Zenia Ferreira, Gavin D Perkins
Published 2017-03-01

Adrenaline to improve survival in out-of-hospital cardiac arrest: the PARAMEDIC2 RCT

by Gavin D Perkins, Chen Ji, Felix Achana, John JM Black, Karl Charlton, James Crawford, Adam de Paeztron, Charles Deakin, Mark Docherty, Judith Finn, Rachael T Fothergill, Simon Gates, Imogen Gunson, Kyee Han, Susie Hennings, Jessica Horton, Kamran Khan, Sarah Lamb, John Long, Joshua Miller, Fionna Moore, Jerry Nolan, Lyndsey O’Shea, Stavros Petrou, Helen Pocock, Tom Quinn, Nigel Rees, Scott Regan, Andy Rosser, Charlotte Scomparin, Anne Slowther, Ranjit Lall
Published 2021-04-01

Stakeholders’ perspectives on clinical trial acceptability and approach to consent within a limited timeframe: a mixed methods study

by Matthew Peak, Kerry Woolfall, Michael Griksaitis, Clare Fowler, Simon Gates, Christopher Lamb, Elizabeth Deja, Rachel Agbeko, John Pappachan, Helen Parker, Jennifer Preston, Ahmed Osman, Paula Williamson, Paul S McNamara, Mark Turner, David Armstrong, Tracy Moitt, Ramesh Kumar, John Alexander, Kevin P Morris, Roger Parslow, Steve Cunningham, Craig Knott, Chloe Donohue, Catrin Barker, Julie Richardson, Ashley Jones, Stephanie Clarke, Malcolm G Semple, Richard Levin, James Weitz, Natasha Roberts, Vanessa Compton, Kentigern Thorburn, PHILIP MILNER, Howard W Clark, Bessie Cipriano, Nosheen Khalid, Nicolene Plaatjies, Avishay Sarfatti, Mark Terris, Santosh Sundararajan, Edgar Brincat, Natasha Thorn, Ramiya Kirupananthan, Peter J Davis, Samantha Owen, Pavanasam Ramesh, Sarah Fox, Laura Price, Hannah Clarke, Charlotte Thompson, Wendy Browne, Constantinos Kanaris, Christine Mackerness, Laura Rad, Grace Williamson, Simone Paulson, Laura O'Malley, Zoe Oliver, Evette Allen, Clare van Miert, Ashley Best, Jens Madsen, Anne Dawson, Colin Summers, Blessing Osaghae, Madhuri Panchal, Anthony Postle, Peter Jirasek, Dawn Jones, Michael Mander, Laura Rimmer, Paul C Ritson, Chris Simons, Afeda Mohamed Ali, Cara Alexander, Hannah Child, Natalie Milburn, Holly Parkin, Harriet Payne, Carly Tooke, Helen Winmill, Katherine Baptiste, Sophie Coles, Sarah-Jayne Eames, Christina Linton, Helen Marley, Sarah Mogan, Alvin Schadenberg, John Stiven, Rob Claydon, Anna Stancombe, Kate Teeley, Kathryn Reeves, Emily Scriven, Raghu N Ramaiah, Rekha Patel, Patrick E Davies, Lindsay Crate, Kirsten Beadon, Rachel McMinnis, Frances Sinfield, Hilary Callaghan, Vicki Linton, Jeremy Lyons, Clara Nelson, Tsz-YanMilly Lo, Jackie McCormick, Andrea Wood, Ross Marscheider, Stephen D Playfor, Bernadette C Gavin, Dave J Morgan, Lara T Bunni, Claire F Jennings, Rebecca Marshall, Emma K Riley, Lorena Caruana, Amber Cook, Tracey Curtis, Nichola Etherington, Jenni McCorkell, Christie Mellish, Jenny Pond, Catherine Postlethwaite, Nicola McClelland, Holly Minchin, Joanne Tomlinson, Simona Lampariello, Tara Murray, Olivia Nugent, Samantha Reed, Christa Ronan, Salman Siddiqi
Published 2024-01-01