Unraveling pleiotropic effects of rifampicin by using physiologically based pharmacokinetic modeling: Assessing the induction magnitude of P‐glycoprotein–cytochrome P450 3A4 dual s...

by Xian Pan, Shinji Yamazaki, Sibylle Neuhoff, Mian Zhang, Venkatesh Pilla Reddy
Published 2021-12-01

PBPK Model of Morphine Incorporating Developmental Changes in Hepatic OCT1 and UGT2B7 Proteins to Explain the Variability in Clearances in Neonates and Small Infants

by Chie Emoto, Trevor N. Johnson, Sibylle Neuhoff, David Hahn, Alexander A. Vinks, Tsuyoshi Fukuda
Published 2018-07-01

Transporter Regulation in Critical Protective Barriers: Focus on Brain and Placenta

by Valerio Taggi, Mario Riera Romo, Micheline Piquette-Miller, Henriette E. Meyer zu Schwabedissen, Sibylle Neuhoff
Published 2022-06-01

Guide to development of compound files for PBPK modeling in the Simcyp population‐based simulator

by Udoamaka Ezuruike, Mian Zhang, Amita Pansari, Mailys De Sousa Mendes, Xian Pan, Sibylle Neuhoff, Iain Gardner
Published 2022-07-01

Performance Verification of CYP2C19 Enzyme Abundance Polymorphism Settings within the Simcyp Simulator v21

by Caroline Sychterz, Iain Gardner, Manting Chiang, Ramakrishna Rachumallu, Sibylle Neuhoff, Vidya Perera, Samira Merali, Brian J. Schmidt, Lu Gaohua
Published 2022-10-01

Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug–Drug Interaction...

by Irina E. Antonescu, Maria Karlgren, Maria L. Pedersen, Ivailo Simoff, Christel A. S. Bergström, Sibylle Neuhoff, Per Artursson, Bente Steffansen, Carsten Uhd Nielsen
Published 2020-04-01

Prediction of CYP‐mediated DDIs involving inhibition: Approaches to address the requirements for system qualification of the Simcyp Simulator

by Peter J. Kilford, Kuan‐Fu Chen, Kim Crewe, Iain Gardner, Oliver Hatley, Alice Ban Ke, Sibylle Neuhoff, Mian Zhang, Karen Rowland Yeo
Published 2022-07-01

Alterations in zonal distribution and plasma membrane localization of hepatocyte bile acid transporters in patients with NAFLD

by William A. Murphy, Anna Mae Diehl, Matthew Shane Loop, Dong Fu, Cynthia D. Guy, Manal F. Abdelmalek, Georgia Sofia Karachaliou, Noora Sjöstedt, Sibylle Neuhoff, Paavo Honkakoski, Kim L. R. Brouwer
Published 2024-03-01