GEF-H1 controls microtubule-dependent sensing of nucleic acids for antiviral host defenses

by Chiang, Hao-Sen, Zhao, Yun, Song, Joo-Hye, Liu, Song, Wang, Ninghai, Terhorst, Cox, Sharpe, Arlene H., Basavappa, Megha, Jeffrey, Kate L., Reinecker, Hans-Christian
Published 2014

The phosphatase PTEN-mediated control of PI-3 kinase in Tregs cells maintains homeostasis and lineage stability

by Huynh, Alexandria, DuPage, Michel, Priyadharshini, Bhavana, Sage, Peter T., Quiros, Jason, Borges, Christopher M., Townamchai, Natavudh, Gerriets, Valerie A., Rathmell, Jeffrey C., Sharpe, Arlene H., Bluestone, Jeffrey A., Turka, Laurence A.
Published 2015

Comprehensive Approaches to Identifying the Targets of Natural and Synthetic Antibodies Using Microarray DNA Synthesis and High-Throughput Sequencing

by Xu, George Jing
Published 2015

CD39 Expression Identifies Terminally Exhausted CD8+ T Cells

by Gupta, Prakash K., Godec, Jernej, Wolski, David, Adland, Emily, Yates, Kathleen, Pauken, Kristen E., Cosgrove, Cormac, Ledderose, Carola, Junger, Wolfgang G., Robson, Simon C., Wherry, E. John, Alter, Galit, Goulder, Philip J. R., Klenerman, Paul, Sharpe, Arlene H., Lauer, Georg M., Haining, W. Nicholas
Published 2015

The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment

by Sharma, Madhav D., Shinde, Rahul, McGaha, Tracy L., Huang, Lei, Holmgaard, Rikke B., Wolchok, Jedd D., Mautino, Mario R., Celis, Esteban, Sharpe, Arlene H., Francisco, Loise M., Powell, Jonathan D., Yagita, Hideo, Mellor, Andrew L., Blazar, Bruce R., Munn, David H.
Published 2015

T Follicular Regulatory Cell–Derived Fibrinogen-like Protein 2 Regulates Production of Autoantibodies and Induction of Systemic Autoimmunity

by Sungnak, Waradon, Wagner, Allon, Kowalczyk, Monika S, Bod, Lloyd, Kye, Yoon-Chul, Sage, Peter T, Sharpe, Arlene H, Sobel, Raymond A, Quintana, Francisco J, Rozenblatt-Rosen, Orit, Regev, Aviv, Wang, Chao, Yosef, Nir, Kuchroo, Vijay K
Published 2021

RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance

by Xiao, Yanping, Yu, Sanhong, Zhu, Baogong, Bedoret, Denis, Bu, Xia, Francisco, Loise M., Hua, Ping, Duke-Cohan, Jonathan S., Umetsu, Dale T., Sharpe, Arlene H., DeKruyff, Rosemarie H., Freeman, Gordon J.
Published 2014

Targeted reconstruction of T cell receptor sequence from single cell RNA-seq links CDR3 length to T cell differentiation state

by Afik, Shaked, Yates, Kathleen B., Bi, Kevin, Darko, Samuel, Godec, Jernej, Gerdemann, Ulrike, Swadling, Leo, Douek, Daniel C., Klenerman, Paul, Barnes, Eleanor J., Sharpe, Arlene H., Haining, W. Nicholas, Yosef, Nir
Published 2018

PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity

by Juneja, Vikram R., McGuire, Kathleen A., Manguso, Robert T., LaFleur, Martin W., Collins, Natalie, Haining, W. Nicholas, Freeman, Gordon J., Sharpe, Arlene H.
Published 2017

Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection

by Penaloza-MacMaster, Pablo, Kamphorst, Alice O., Wieland, Andreas, Araki, Koichi, Iyer, Smita S., West, Erin E., O’Mara, Leigh, Yang, Shu, Konieczny, Bogumila T., Sharpe, Arlene H., Freeman, Gordon J., Rudensky, Alexander Y., Ahmed, Rafi
Published 2015

Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity

by Paterson, Alison M., Lovitch, Scott B., Sage, Peter T., Juneja, Vikram R., Lee, Youjin, Trombley, Justin D., Arancibia-Cárcamo, Carolina V., Sobel, Raymond A., Rudensky, Alexander Y., Kuchroo, Vijay K., Freeman, Gordon J., Sharpe, Arlene H.
Published 2016

BRAF inhibition is associated with increased clonality in tumor-infiltrating lymphocytes

by Cooper, Zachary A, Frederick, Dennie T, Juneja, Vikram R, Sullivan, Ryan J, Lawrence, Donald P, Piris, Adriano, Sharpe, Arlene H, Fisher, David E, Flaherty, Keith T, Wargo, Jennifer A
Published 2014

Inclusion of CD80 in HSV Targets the Recombinant Virus to PD-L1 on DCs and Allows Productive Infection and Robust Immune Responses

by Mott, Kevin R., Allen, Sariah J., Zandian, Mandana, Akbari, Omid, Hamrah, Pedram, Maazi, Hadi, Wechsler, Steven L., Sharpe, Arlene H., Freeman, Gordon J., Ghiasi, Homayon
Published 2014

Distinct clinical patterns and immune infiltrates are observed at time of progression on targeted therapy versus immune checkpoint blockade for melanoma

by Cooper, Zachary A., Reuben, Alexandre, Spencer, Christine N., Prieto, Peter A., Austin-Breneman, Jacob L., Jiang, Hong, Haymaker, Cara, Gopalakrishnan, Vancheswaran, Tetzlaff, Michael T., Frederick, Dennie T., Sullivan, Ryan J., Amaria, Rodabe N., Patel, Sapna P., Hwu, Patrick, Woodman, Scott E., Glitza, Isabella C., Diab, Adi, Vence, Luis M., Rodriguez-Canales, Jaime, Parra, Edwin R., Wistuba, Ignacio I., Coussens, Lisa M., Sharpe, Arlene H., Flaherty, Keith T., Gershenwald, Jeffrey E., Chin, Lynda, Davies, Michael A., Clise-Dwyer, Karen, Allison, James P., Sharma, Padmanee, Wargo, Jennifer A.
Published 2016

The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells

by Khor, Bernard, Gagnon, John D, Goel, Gautam, Roche, Marly I, Conway, Kara L, Tran, Khoa, Aldrich, Leslie N, Sundberg, Thomas B, Paterson, Alison M, Mordecai, Scott, Dombkowski, David, Schirmer, Melanie, Tan, Pauline H, Bhan, Atul K, Roychoudhuri, Rahul, Restifo, Nicholas P, O'Shea, John J, Medoff, Benjamin D, Shamji, Alykhan F, Schreiber, Stuart L, Sharpe, Arlene H, Shaw, Stanley Y, Xavier, Ramnik J
Published 2015

The Development of a Statistical Model to Study How the Deletion of PD-1 Promotes Anti-Tumor Immunity

by Diallo, Alos Burgess
Published 2021

In Vivo Genetic Screening to Identify Mechanisms of Resistance to Cancer Immunotherapy

by Manguso, Robert T.
Published 2019

Helicobacter pylori cag Pathogenicity Island's Role in B7-H1 Induction and Immune Evasion

by Lina, Taslima T., Alzahrani, Shatha, House, Jennifer, Yamaoka, Yoshio, Sharpe, Arlene H., Rampy, Bill A., Pinchuk, Irina V., Reyes, Victor E.
Published 2015

CD4 T Cell-Derived IFN-γ Plays a Minimal Role in Control of Pulmonary Mycobacterium tuberculosis Infection and Must Be Actively Repressed by PD-1 to Prevent Lethal Disease

by Sakai, Shunsuke, Kauffman, Keith D., Sallin, Michelle A., Sharpe, Arlene H., Young, Howard A., Ganusov, Vitaly V., Barber, Daniel L.
Published 2016

Targeting PI3Kδ function for amelioration of murine chronic graft-versus-host disease.

by Paz, Katelyn, Flynn, Ryan, Du, Jing, Tannheimer, Stacey, Johnson, Amy J, Dong, Shuai, Stark, Anne-Katrien, Okkenhaug, Klaus, Panoskaltsis-Mortari, Angela, Sage, Peter T, Sharpe, Arlene H, Luznik, Leo, Ritz, Jerome, Soiffer, Robert J, Cutler, Corey S, Koreth, John, Antin, Joseph H, Miklos, David B, MacDonald, Kelli P, Hill, Geoffrey R, Maillard, Ivan, Serody, Jonathan S, Murphy, William J, Munn, David H, Feser, Colby, Zaiken, Michael, Vanhaesebroeck, Bart, Turka, Laurence A, Byrd, John C, Blazar, Bruce R
Published 2019