PRMT5 regulates ATF4 transcript splicing and oxidative stress response

by Magdalena M. Szewczyk, Genna M. Luciani, Victoria Vu, Alex Murison, David Dilworth, Samir H. Barghout, Mathieu Lupien, Cheryl H. Arrowsmith, Mark D. Minden, Dalia Barsyte-Lovejoy
Published 2022-05-01

A genome-wide CRISPR/Cas9 screen in acute myeloid leukemia cells identifies regulators of TAK-243 sensitivity

by Samir H. Barghout, Ahmed Aman, Kazem Nouri, Zachary Blatman, Karen Arevalo, Geethu E. Thomas, Neil MacLean, Rose Hurren, Troy Ketela, Mehakpreet Saini, Moustafa Abohawya, Taira Kiyota, Rima Al-Awar, Aaron D. Schimmer
Published 2021-03-01

The thymidine dideoxynucleoside analog, alovudine, inhibits the mitochondrial DNA polymerase γ, impairs oxidative phosphorylation and promotes monocytic differentiation in acute my...

by Dana Yehudai, Sanduni U. Liyanage, Rose Hurren, Biljana Rizoska, Mark Albertella, Marcela Gronda, Danny V Jeyaraju, Xiaoming Wang, Samir H. Barghout, Neil MacLean, Thirushi P. Siriwardena, Yulia Jitkova, Paul Targett-Adams, Aaron D. Schimmer
Published 2019-05-01

Presentation and outcomes of KRASG12C mutant non-small cell lung cancer patients with stage IV disease at diagnosis (de novo) versus at recurrence

by Niki Esfahanian, Sze Wah Samuel Chan, Luna J. Zhan, M.Catherine Brown, Khaleeq Khan, Jae Lee, Karmugi Balaratnam, Elizabeth Yan, Jennifer Parker, Miguel Garcia-Pardo, Samir H. Barghout, Lawson Eng, Penelope A. Bradbury, Frances A. Shepherd, Natasha B. Leighl, Adrian G. Sacher, Stephanie Snow, Rosalyn Juergens, Geoffrey Liu
Published 2023-01-01