The Role of Ceramides in Diabetes and Cardiovascular Disease Regulation of Ceramides by Adipokines

by Bianca C. Field, Ruth Gordillo, Philipp E. Scherer, Philipp E. Scherer
Published 2020-10-01

Replenishment of TCA cycle intermediates provides photoreceptor resilience against neurodegeneration during progression of retinitis pigmentosa

by Ashley A. Rowe, Pinkal D. Patel, Ruth Gordillo, Katherine J. Wert
Published 2021-09-01

Role of ceramide-to-dihydroceramide ratios for insulin resistance and non-alcoholic fatty liver disease in humans

by Irene Esposito, Michael Roden, Christian Herder, Maria Apostolopoulou, Ruth Gordillo, Sofiya Gancheva, Klaus Strassburger, Matthias Schlensak, Philipp E Scherer
Published 2020-12-01

The dual lipid desaturase/hydroxylase DEGS2 controls phytoceramide levels necessary to counter intestinal inflammation

by Ran Song, Aaron Fond, Xiaohong Li, Miao Tang, Xiaoming Zhan, Ruth Gordillo, Eva Marie Y. Moresco, Bruce Beutler, Emre E. Turer
Published 2023-09-01

PEGylated AdipoRon derivatives improve glucose and lipid metabolism under insulinopenic and high-fat diet conditions

by Toshiharu Onodera, Ebrahim Ghazvini Zadeh, Peng Xu, Ruth Gordillo, Zheng Guo, Nolwenn Joffin, Biao Yu, Philipp E. Scherer, Wen-hong Li
Published 2021-01-01

Adiponectin is essential for lipid homeostasis and survival under insulin deficiency and promotes β-cell regeneration

by Risheng Ye, William L Holland, Ruth Gordillo, Miao Wang, Qiong A Wang, Mengle Shao, Thomas S Morley, Rana K Gupta, Andreas Stahl, Philipp E Scherer
Published 2014-10-01

Inducible overexpression of adiponectin receptors highlight the roles of adiponectin-induced ceramidase signaling in lipid and glucose homeostasis

by William L. Holland, Jonathan Y. Xia, Joshua A. Johnson, Kai Sun, Mackenzie J. Pearson, Ankit X. Sharma, Ezekiel Quittner-Strom, Trevor S. Tippetts, Ruth Gordillo, Philipp E. Scherer
Published 2017-03-01

Ceramides are early responders in metabolic syndrome development in rhesus monkeys

by Alex B. Smith, Jonah P. Schill, Ruth Gordillo, Grace E. Gustafson, Timothy W. Rhoads, Maggie S. Burhans, Aimee T. Broman, Ricki J. Colman, Philipp E. Scherer, Rozalyn M. Anderson
Published 2022-06-01

Adipocyte Xbp1s overexpression drives uridine production and reduces obesity

by Yingfeng Deng, Zhao V. Wang, Ruth Gordillo, Yi Zhu, Aktar Ali, Chen Zhang, Xiaoding Wang, Mengle Shao, Zhuzhen Zhang, Puneeth Iyengar, Rana K. Gupta, Jay D. Horton, Joseph A. Hill, Philipp E. Scherer
Published 2018-05-01

Protective roles of adiponectin and molecular signatures of HNF4α and PPARα as downstream targets of adiponectin in pancreatic β cells

by Toshiharu Onodera, Dae-Seok Kim, Risheng Ye, May-Yun Wang, Shiuhwei Chen, Bianca C. Field, Leon Straub, Xue-Nan Sun, Chao Li, Charlotte Lee, Megan Paredes, Clair Crewe, Shangang Zhao, Christine M. Kusminski, Ruth Gordillo, Philipp E. Scherer
Published 2023-12-01

Hypothalamic PGC-1α Protects Against High-Fat Diet Exposure by Regulating ERα

by Eugenia Morselli, Esther Fuente-Martin, Brian Finan, Min Kim, Aaron Frank, Cristina Garcia-Caceres, Carlos Rodriguez Navas, Ruth Gordillo, Michael Neinast, Sarada P. Kalainayakan, Dan L. Li, Yuanqing Gao, Chun-Xia Yi, Lisa Hahner, Biff F. Palmer, Matthias H. Tschöp, Deborah J. Clegg
Published 2014-10-01

Adiponectin preserves metabolic fitness during aging

by Na Li, Shangang Zhao, Zhuzhen Zhang, Yi Zhu, Christy M Gliniak, Lavanya Vishvanath, Yu A An, May-yun Wang, Yingfeng Deng, Qingzhang Zhu, Bo Shan, Amber Sherwood, Toshiharu Onodera, Orhan K Oz, Ruth Gordillo, Rana K Gupta, Ming Liu, Tamas L Horvath, Vishwa Deep Dixit, Philipp E Scherer
Published 2021-04-01

Adipose tissue hyaluronan production improves systemic glucose homeostasis and primes adipocytes for CL 316,243-stimulated lipolysis

by Yi Zhu, Na Li, Mingyang Huang, Mason Bartels, Sophie Dogné, Shangang Zhao, Xi Chen, Clair Crewe, Leon Straub, Lavanya Vishvanath, Zhuzhen Zhang, Mengle Shao, Yongjie Yang, Christy M. Gliniak, Ruth Gordillo, Gordon I. Smith, William L. Holland, Rana K. Gupta, Bingning Dong, Nathalie Caron, Yong Xu, Yucel Akgul, Samuel Klein, Philipp E. Scherer
Published 2021-08-01

Glucagon Receptor Antagonism Improves Glucose Metabolism and Cardiac Function by Promoting AMP-Mediated Protein Kinase in Diabetic Mice

by Ankit X. Sharma, Ezekiel B. Quittner-Strom, Young Lee, Joshua A. Johnson, Sarah A. Martin, Xinxin Yu, Jianping Li, John Lu, Zheqing Cai, Shiuhwei Chen, May-yun Wang, Yiyi Zhang, Mackenzie J. Pearson, Andie C. Dorn, Jeffrey G. McDonald, Ruth Gordillo, Hai Yan, Dung Thai, Zhao V. Wang, Roger H. Unger, William L. Holland
Published 2018-02-01

Endogenous renal adiponectin drives gluconeogenesis through enhancing pyruvate and fatty acid utilization

by Toshiharu Onodera, May-Yun Wang, Joseph M. Rutkowski, Stanislaw Deja, Shiuhwei Chen, Michael S. Balzer, Dae-Seok Kim, Xuenan Sun, Yu A. An, Bianca C. Field, Charlotte Lee, Ei-ichi Matsuo, Monika Mizerska, Ina Sanjana, Naoto Fujiwara, Christine M. Kusminski, Ruth Gordillo, Laurent Gautron, Denise K. Marciano, Ming Chang Hu, Shawn C. Burgess, Katalin Susztak, Orson W. Moe, Philipp E. Scherer
Published 2023-10-01