3,4-Dihydroxyphenylethanol (DPE or Hydroxytyrosol) Counteracts ERK1/2 and mTOR Activation, Pro-Inflammatory Cytokine Release, Autophagy and Mitophagy Reduction Mediated by Benzo[a]...

by Roberta Santarelli, Chiara Pompili, Maria Saveria Gilardini Montani, Lorenzo Evangelista, Roberta Gonnella, Mara Cirone
Published 2022-03-01

HSPs/STAT3 Interplay Sustains DDR and Promotes Cytokine Release by Primary Effusion Lymphoma Cells

by Roberta Gonnella, Andrea Arena, Roberta Zarrella, Maria Saveria Gilardini Montani, Roberta Santarelli, Mara Cirone
Published 2023-02-01

IRE1 Alpha/XBP1 Axis Sustains Primary Effusion Lymphoma Cell Survival by Promoting Cytokine Release and STAT3 Activation

by Roberta Gonnella, Maria Saveria Gilardini Montani, Luisa Guttieri, Maria Anele Romeo, Roberta Santarelli, Mara Cirone
Published 2021-01-01

Mechanisms of Sensitivity and Resistance of Primary Effusion Lymphoma to Dimethyl Fumarate (DMF)

by Roberta Gonnella, Roberta Zarrella, Roberta Santarelli, Concetta Anna Germano, Maria Saveria Gilardini Montani, Mara Cirone
Published 2022-06-01

Viral Infection and Autophagy Dysregulation: The Case of HHV-6, EBV and KSHV

by Maria Anele Romeo, Roberta Santarelli, Maria Saveria Gilardini Montani, Roberta Gonnella, Rossella Benedetti, Alberto Faggioni, Mara Cirone
Published 2020-12-01

Zinc Supplementation Enhances the Pro-Death Function of UPR in Lymphoma Cells Exposed to Radiation

by Roberta Gonnella, Luisa Guttieri, Maria Saveria Gilardini Montani, Roberta Santarelli, Erica Bassetti, Gabriella D’Orazi, Mara Cirone
Published 2022-01-01

Concomitant Inhibition of IRE1α/XBP1 Axis of UPR and PARP: A Promising Therapeutic Approach against c-Myc and Gammaherpesvirus-Driven B-Cell Lymphomas

by Rossella Benedetti, Andrea Arena, Maria Anele Romeo, Maria Saveria Gilardini Montani, Roberta Gonnella, Roberta Santarelli, Pankaj Trivedi, Mara Cirone
Published 2022-08-01

NRF2 and STAT3: friends or foes in carcinogenesis?

by Andrea Arena, Maria Anele Romeo, Rossella Benedetti, Maria Saveria Gilardini Montani, Roberta Santarelli, Roberta Gonnella, Gabriella D’Orazi, Mara Cirone
Published 2023-03-01

Primary effusion lymphoma cell death induced by bortezomib and AG 490 activates dendritic cells through CD91.

by Mara Cirone, Livia Di Renzo, Lavinia Vittoria Lotti, Valeria Conte, Pankaj Trivedi, Roberta Santarelli, Roberta Gonnella, Luigi Frati, Alberto Faggioni
Published 2012-01-01

HSP110 Inhibition in Primary Effusion Lymphoma Cells: One Molecule, Many Pro-Survival Targets

by Roberta Gonnella, Roberta Zarrella, Michele Di Crosta, Rossella Benedetti, Andrea Arena, Roberta Santarelli, Maria Saveria Gilardini Montani, Gabriella D’Orazi, Mara Cirone
Published 2023-11-01

Quercetin Interrupts the Positive Feedback Loop Between STAT3 and IL-6, Promotes Autophagy, and Reduces ROS, Preventing EBV-Driven B Cell Immortalization

by Marisa Granato, Maria Saveria Gilardini Montani, Claudia Zompetta, Roberta Santarelli, Roberta Gonnella, Maria Anele Romeo, Gabriella D’Orazi, Alberto Faggioni, Mara Cirone
Published 2019-09-01

EBV infection of primary colonic epithelial cells causes inflammation, DDR and autophagy dysregulation, effects that may predispose to IBD and carcinogenesis

by Roberta Santarelli, Lorenzo Evangelista, Chiara Pompili, Salvatore Lo Presti, Alberto Rossi, Andrea Arena, Aurelia Gaeta, Roberta Gonnella, Maria Saveria Gilardini Montani, Mara Cirone
Published 2023-12-01

The inhibition of IRE1alpha/XBP1 axis prevents EBV-driven lymphomagenesis in NSG mice

by Andrea Arena, Maria Anele Romeo, Agnese Po, Rossella Benedetti, Maria Saveria Gilardini Montani, Roberta Gonnella, Roberta Santarelli, Aurelia Gaeta, Enrico De Smaele, Mara Cirone
Published 2023-12-01

JNK and macroautophagy activation by bortezomib has a pro-survival effect in primary effusion lymphoma cells.

by Marisa Granato, Roberta Santarelli, Lavinia V Lotti, Livia Di Renzo, Roberta Gonnella, Alessia Garufi, Pankaj Trivedi, Luigi Frati, Gabriella D'Orazi, Alberto Faggioni, Mara Cirone
Published 2013-01-01

NFE2L2 and STAT3 Converge on Common Targets to Promote Survival of Primary Lymphoma Cells

by Andrea Arena, Michele Di Crosta, Roberta Gonnella, Roberta Zarrella, Maria Anele Romeo, Rossella Benedetti, Maria Saveria Gilardini Montani, Roberta Santarelli, Gabriella D’Orazi, Mara Cirone
Published 2023-07-01