Mutation in the Common Docking Domain Affects MAP Kinase ERK2 Catalysis and Stability

by Leonore Novak, Maria Petrosino, Alessandra Pasquo, Apirat Chaikuad, Roberta Chiaraluce, Stefan Knapp, Valerio Consalvi
Published 2023-05-01

Structural stability of human protein tyrosine phosphatase ρ catalytic domain: effect of point mutations.

by Alessandra Pasquo, Valerio Consalvi, Stefan Knapp, Ivan Alfano, Matteo Ardini, Simonetta Stefanini, Roberta Chiaraluce
Published 2012-01-01

Effect of single amino acid substitution observed in cancer on Pim-1 kinase thermodynamic stability and structure.

by Clorinda Lori, Antonella Lantella, Alessandra Pasquo, Leila T Alexander, Stefan Knapp, Roberta Chiaraluce, Valerio Consalvi
Published 2013-01-01

Analysis and Interpretation of the Impact of Missense Variants in Cancer

by Maria Petrosino, Leonore Novak, Alessandra Pasquo, Roberta Chiaraluce, Paola Turina, Emidio Capriotti, Valerio Consalvi
Published 2021-05-01

A Glimpse into the Structural Properties of the Intermediate and Transition State in the Folding of Bromodomain 2 Domain 2 by Φ Value Analysis

by Leonore Novak, Maria Petrosino, Daniele Santorelli, Roberta Chiaraluce, Valerio Consalvi, Alessandra Pasquo, Carlo Travaglini-Allocatelli
Published 2021-05-01

Unveiling the folding mechanism of the Bromodomains

by Maria Petrosino, Daniela Bonetti, Alessandra Pasquo, Laura Lori, Roberta Chiaraluce, Valerio Consalvi, Carlo Travaglini-Allocatelli
Published 2017-09-01

Effect of BET Missense Mutations on Bromodomain Function, Inhibitor Binding and Stability.

by Laura Lori, Alessandra Pasquo, Clorinda Lori, Maria Petrosino, Roberta Chiaraluce, Cynthia Tallant, Stefan Knapp, Valerio Consalvi
Published 2016-01-01

The phosphoglycerate kinase 1 variants found in carcinoma cells display different catalytic activity and conformational stability compared to the native enzyme.

by Annarita Fiorillo, Maria Petrosino, Andrea Ilari, Alessandra Pasquo, Alessandra Cipollone, Maristella Maggi, Roberta Chiaraluce, Valerio Consalvi
Published 2018-01-01

The complex impact of cancer-related missense mutations on the stability and on the biophysical and biochemical properties of MAPK1 and MAPK3 somatic variants

by Maria Petrosino, Leonore Novak, Alessandra Pasquo, Paola Turina, Emidio Capriotti, Velia Minicozzi, Valerio Consalvi, Roberta Chiaraluce
Published 2023-10-01

Single-Nucleotide Polymorphism of PPARγ, a Protein at the Crossroads of Physiological and Pathological Processes

by Maria Petrosino, Laura Lori, Alessandra Pasquo, Clorinda Lori, Valerio Consalvi, Velia Minicozzi, Silvia Morante, Antonio Laghezza, Alessandra Giorgi, Davide Capelli, Roberta Chiaraluce
Published 2017-02-01

Oligomerization of Sulfolobus solfataricus signature amidase is promoted by acidic pH and high temperature

by Anna Scotto D’Abusco, Rita Casadio, Gianluca Tasco, Laura Giangiacomo, Anna Giartosio, Valentina Calamia, Stefania Di Marco, Roberta Chiaraluce, Valerio Consalvi, Roberto Scandurra, Laura Politi
Published 2005-01-01

Zn‐Induced Interactions Between SARS‐CoV‐2 orf7a and BST2/Tetherin

by Dr. Maria Petrosino, Dr. Francesco Stellato, Prof. Roberta Chiaraluce, Prof. Valerio Consalvi, Dr. Giovanni La Penna, Dr. Alessandra Pasquo, Dr. Olivier Proux, Prof. Giancarlo Rossi, Prof. Silvia Morante
Published 2021-11-01