A Single Nucleotide Polymorphism in the Gene Promoter Affects Transcription and Influences Retinal Ganglion Cell Death

by Sheila J Semaan, Yan Li, Robert W Nickells
Published 2010-03-01

Live-cell imaging to measure BAX recruitment kinetics to mitochondria during apoptosis.

by Margaret E Maes, Cassandra L Schlamp, Robert W Nickells
Published 2017-01-01

BCLXL gene therapy moderates neuropathology in the DBA/2J mouse model of inherited glaucoma

by Ryan J. Donahue, Rachel L. Fehrman, Jenna R. Gustafson, Robert W. Nickells
Published 2021-08-01

The effects of a mitochondrial targeted peptide (elamipretide/SS31) on BAX recruitment and activation during apoptosis

by Joshua A. Grosser, Rachel L. Fehrman, Dennis Keefe, Martin Redmon, Robert W. Nickells
Published 2021-05-01

BclX L (Bcl2l1) gene therapy lessens retinal ganglion cell soma loss but not axonal degeneration after acute axonal injury

by Olivia J. Marola, Sarah E. R. Yablonski, Peter G. Shrager, Robert W. Nickells, Richard T. Libby
Published 2022-07-01

The Influence of Mitochondrial Dynamics and Function on Retinal Ganglion Cell Susceptibility in Optic Nerve Disease

by Nicole A. Muench, Sonia Patel, Margaret E. Maes, Ryan J. Donahue, Akihiro Ikeda, Robert W. Nickells
Published 2021-06-01

Contralateral Astrocyte Response to Acute Optic Nerve Damage Is Mitigated by PANX1 Channel Activity

by Jasmine A. Wurl, Caitlin E. Mac Nair, Joel A. Dietz, Valery I. Shestopalov, Robert W. Nickells
Published 2023-10-01

BAX activation in mouse retinal ganglion cells occurs in two temporally and mechanistically distinct steps

by Margaret E. Maes, Ryan J. Donahue, Cassandra L. Schlamp, Olivia J. Marola, Richard T. Libby, Robert W. Nickells
Published 2023-09-01

Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage.

by Richard T Libby, Yan Li, Olga V Savinova, Joseph Barter, Richard S Smith, Robert W Nickells, Simon W M John
Published 2005-07-01

Spink2 modulates apoptotic susceptibility and is a candidate gene in the Rgcs1 QTL that affects retinal ganglion cell death after optic nerve damage.

by Joel A Dietz, Margaret E Maes, Shuang Huang, Brian S Yandell, Cassandra L Schlamp, Angela D Montgomery, R Rand Allingham, Michael A Hauser, Robert W Nickells
Published 2014-01-01