Sensitive intranuclear flow cytometric quantification of IRF4 protein in multiple myeloma and normal human hematopoietic cells

by Ashni A. Vora, Phoebe K. Mondala, Caitlin Costello, A. Robert MacLeod, Leslie A. Crews
Published 2021-06-01

Identifying locations of re-entrant drivers from patient-specific distribution of fibrosis in the left atrium.

by Aditi Roy, Marta Varela, Henry Chubb, Robert MacLeod, Jules C Hancox, Tobias Schaeffter, Oleg Aslanidi
Published 2020-09-01

Interferon regulatory factor 4 as a therapeutic target in adult T-cell leukemia lymphoma

by Daniel A. Rauch, Sydney L. Olson, John C. Harding, Hemalatha Sundaramoorthi, Youngsoo Kim, Tianyuan Zhou, A. Robert MacLeod, Grant Challen, Lee Ratner
Published 2020-08-01

Kininogen supports inflammation and bacterial spreading during Streptococccus Pyogenes Sepsis

by Juliane Köhler, Claudia Maletzki, Dirk Koczan, Marcus Frank, Armin Springer, Carolin Steffen, Alexey S. Revenko, A.Robert MacLeod, Stefan Mikkat, Bernd Kreikemeyer, Sonja Oehmcke-Hecht
Published 2020-08-01

LncRNA PVT1 Is a Poor Prognosticator and Can Be Targeted by PVT1 Antisense Oligos in Gastric Adenocarcinoma

by Yuan Li, Shumei Song, Melissa Pool Pizzi, Guangchun Han, Ailing W. Scott, Jiankang Jin, Yan Xu, Ying Wang, Longfei Huo, Lang Ma, Christopher Vellano, Xiaolin Luo, Robert MacLeod, Linghua Wang, Zhenning Wang, Jaffer A. Ajani
Published 2020-10-01

Antisense oligonucleotide activity in tumour cells is influenced by intracellular LBPA distribution and extracellular vesicle recycling

by Alexander N. Kapustin, Paul Davey, David Longmire, Carl Matthews, Emily Linnane, Nitin Rustogi, Maria Stavrou, Paul W. A. Devine, Nicholas J. Bond, Lyndsey Hanson, Silvia Sonzini, Alexey Revenko, A. Robert MacLeod, Sarah Ross, Elisabetta Chiarparin, Sanyogitta Puri
Published 2021-11-01

Inhibition of MER proto-oncogene tyrosine kinase by an antisense oligonucleotide enhances treatment efficacy of immunoradiotherapy

by Yun Hu, Alexey Revenko, Hampartsoum Barsoumian, Genevieve Bertolet, Natalie Wall Fowlkes, Hadi Maazi, Morgan Maureen Green, Kewen He, Duygu Sezen, Tiffany A. Voss, Claudia S Kettlun Leyton, Fatemeh Masrorpour, Zahid Rafiq, Nahum Puebla-Osorio, Carola Leuschner, Robert MacLeod, Maria Angelica Cortez, James W. Welsh
Published 2024-03-01

Activation of P-TEFb by Androgen Receptor-Regulated Enhancer RNAs in Castration-Resistant Prostate Cancer

by Yu Zhao, Liguo Wang, Shancheng Ren, Lan Wang, Patrick R. Blackburn, Melissa S. McNulty, Xu Gao, Meng Qiao, Robert L. Vessella, Manish Kohli, Jun Zhang, R. Jeffrey Karnes, Donald J. Tindall, Youngsoo Kim, Robert MacLeod, Stephen C. Ekker, Tiebang Kang, Yinghao Sun, Haojie Huang
Published 2016-04-01

LncRNA PVT1 up-regulation is a poor prognosticator and serves as a therapeutic target in esophageal adenocarcinoma

by Yan Xu, Yuan Li, Jiankang Jin, Guangchun Han, Chengcao Sun, Melissa Pool Pizzi, Longfei Huo, Ailing Scott, Ying Wang, Lang Ma, Jeffrey H. Lee, Manoop S. Bhutani, Brian Weston, Christopher Vellano, Liuqing Yang, Chunru Lin, Youngsoo Kim, A. Robert MacLeod, Linghua Wang, Zhenning Wang, Shumei Song, Jaffer A. Ajani
Published 2019-10-01

Correction to: LncRNA PVT1 up-regulation is a poor prognosticator and serves as a therapeutic target in esophageal adenocarcinoma

by Yan Xu, Yuan Li, Jiankang Jin, Guangchun Han, Chengcao Sun, Melissa Pool Pizzi, Longfei Huo, Ailing Scott, Ying Wang, Lang Ma, Jeffrey H. Lee, Manoop S. Bhutani, Brian Weston, Christopher Vellano, Liuqing Yang, Chunru Lin, Youngsoo Kim, A. Robert MacLeod, Linghua Wang, Zhenning Wang, Shumei Song, Jaffer A. Ajani
Published 2021-03-01

Direct targeting of FOXP3 in Tregs with AZD8701, a novel antisense oligonucleotide to relieve immunosuppression in cancer

by Matthew King, Melissa Chapman, Vasu Sah, Paul Lyne, Alexey Revenko, Charles Sinclair, Ben Johnson, Maneesh Singh, Andrew Watt, Maelle Mairesse, Larissa S Carnevalli, Alison Peter, Molly Taylor, Lisa Hettrick, Stephanie Klein, Anisha Solanki, Danielle Gattis, Adina M Hughes, Lukasz Magiera, Gozde Kar, Lucy Ireland, Deanna A Mele, Josephine Walton, Mark Edbrooke, Simon T Barry, Stephen Fawell, Frederick W Goldberg, A Robert MacLeod
Published 2022-04-01

STAT3 antisense oligonucleotide AZD9150 in a subset of patients with heavily pretreated lymphoma: results of a phase 1b trial

by Matthew J. Reilley, Patricia McCoon, Carl Cook, Paul Lyne, Razelle Kurzrock, Youngsoo Kim, Richard Woessner, Anas Younes, John Nemunaitis, Nathan Fowler, Michael Curran, Qinying Liu, Tianyuan Zhou, Joanna Schmidt, Minji Jo, Samantha J. Lee, Mason Yamashita, Steven G. Hughes, Luis Fayad, Sarina Piha-Paul, Murali V. P. Nadella, Xiaokun Xiao, Jeff Hsu, Alexey Revenko, Brett P. Monia, A. Robert MacLeod, David S. Hong
Published 2018-11-01

The androgen receptor is a therapeutic target in desmoplastic small round cell sarcoma

by Salah-Eddine Lamhamedi-Cherradi, Mayinuer Maitituoheti, Brian A. Menegaz, Sandhya Krishnan, Amelia M. Vetter, Pamela Camacho, Chia-Chin Wu, Hannah C. Beird, Robert W. Porter, Davis R. Ingram, Vandhana Ramamoorthy, Sana Mohiuddin, David McCall, Danh D. Truong, Branko Cuglievan, P. Andrew Futreal, Alejandra Ruiz Velasco, Nazanin Esmaeili Anvar, Budi Utama, Mark Titus, Alexander J. Lazar, Wei-Lien Wang, Cristian Rodriguez-Aguayo, Ravin Ratan, J. Andrew Livingston, Kunal Rai, A. Robert MacLeod, Najat C. Daw, Andrea Hayes-Jordan, Joseph A. Ludwig
Published 2022-06-01