Antigen presentation by clonally diverse CXCR5+ B cells to CD4 and CD8 T cells is associated with durable response to immune checkpoint inhibitors

by Lizhong Ding, Lizhong Ding, Lu Sun, Lu Sun, Melissa T. Bu, Yanjun Zhang, Yanjun Zhang, Lauren N. Scott, Robert M. Prins, Robert M. Prins, Robert M. Prins, Robert M. Prins, Maureen A. Su, Maureen A. Su, Maureen A. Su, Maureen A. Su, Melissa G. Lechner, Melissa G. Lechner, Willy Hugo, Willy Hugo, Willy Hugo
Published 2023-06-01

Evidence for Innate and Adaptive Immune Responses in a Cohort of Intractable Pediatric Epilepsy Surgery Patients

by Geoffrey C. Owens, Alejandro J. Garcia, Aaron Y. Mochizuki, Aaron Y. Mochizuki, Julia W. Chang, Julia W. Chang, Samuel D. Reyes, Noriko Salamon, Robert M. Prins, Robert M. Prins, Robert M. Prins, Robert M. Prins, Gary W. Mathern, Gary W. Mathern, Gary W. Mathern, Gary W. Mathern, Aria Fallah, Aria Fallah, Aria Fallah
Published 2019-01-01

1491 Aberrant EGFR activation drives enhanced infiltration of immunosuppressive microglia and macrophages in the glioblastoma tumor immune microenvironment

by Robert M Prins, Katie B Grausam, Joshua J Breunig, Marissa S Pioso, Marissa Li, David A Nathanson
Published 2023-11-01

Correction: Monitoring of Regulatory T Cell Frequencies and Expression of CTLA-4 on T Cells, before and after DC Vaccination, Can Predict Survival in GBM Patients.

by Brendan Fong, Richard Jin, Xiaoyan Wang, Michael Safaee, Dominique N. Lisiero, Isaac Yang, Gang Li, Linda M. Liau, Robert M. Prins
Published 2012-01-01

Monitoring of regulatory T cell frequencies and expression of CTLA-4 on T cells, before and after DC vaccination, can predict survival in GBM patients.

by Brendan Fong, Richard Jin, Xiaoyan Wang, Michael Safaee, Dominique N Lisiero, Isaac Yang, Gang Li, Linda M Liau, Robert M Prins
Published 2012-01-01

Correction: Monitoring of Regulatory T Cell Frequencies and Expression of CTLA-4 on T Cells, before and after DC Vaccination, Can Predict Survival in GBM Patients.

by Brendan Fong, Richard Jin, Xiaoyan Wang, Michael Safaee, Dominique N. Lisiero, Isaac Yang, Gang Li, Linda M. Liau, Robert M. Prins
Published 2012-01-01

Resolution of tissue signatures of therapy response in patients with recurrent GBM treated with neoadjuvant anti-PD1

by Yue Lu, Alphonsus H. C. Ng, Frances E. Chow, Richard G. Everson, Beth A. Helmink, Michael T. Tetzlaff, Rohit Thakur, Jennifer A. Wargo, Timothy F. Cloughesy, Robert M. Prins, James R. Heath
Published 2021-06-01

Author Correction: TLR agonists polarize interferon responses in conjunction with dendritic cell vaccination in malignant glioma: a randomized phase II Trial

by Richard G. Everson, Willy Hugo, Lu Sun, Joseph Antonios, Alexander Lee, Lizhong Ding, Melissa Bu, Sara Khattab, Carolina Chavez, Emma Billingslea-Yoon, Andres Salazar, Benjamin M. Ellingson, Timothy F. Cloughesy, Linda M. Liau, Robert M. Prins
Published 2024-06-01

TLR agonists polarize interferon responses in conjunction with dendritic cell vaccination in malignant glioma: a randomized phase II Trial

by Richard G. Everson, Willy Hugo, Lu Sun, Joseph Antonios, Alexander Lee, Lizhong Ding, Melissa Bu, Sara Khattab, Carolina Chavez, Emma Billingslea-Yoon, Andres Salazar, Benjamin M. Ellingson, Timothy F. Cloughesy, Linda M. Liau, Robert M. Prins
Published 2024-05-01

Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma

by Alexander H. Lee, Lu Sun, Aaron Y. Mochizuki, Jeremy G. Reynoso, Joey Orpilla, Frances Chow, Jenny C. Kienzler, Richard G. Everson, David A. Nathanson, Steven J. Bensinger, Linda M. Liau, Timothy Cloughesy, Willy Hugo, Robert M. Prins
Published 2021-11-01

Immune checkpoint blockade induces distinct alterations in the microenvironments of primary and metastatic brain tumors

by Lu Sun, Jenny C. Kienzler, Jeremy G. Reynoso, Alexander Lee, Eileen Shiuan, Shanpeng Li, Jiyoon Kim, Lizhong Ding, Amber J. Monteleone, Geoffrey C. Owens, Joanna J. Phillips, Richard G. Everson, David Nathanson, Timothy F. Cloughesy, Gang Li, Linda M. Liau, Willy Hugo, Won Kim, Robert M. Prins
Published 2023-09-01

Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities

by Matthew Garrett, Jantzen Sperry, Daniel Braas, Weihong Yan, Thuc M. Le, Jack Mottahedeh, Kirsten Ludwig, Ascia Eskin, Yue Qin, Rachelle Levy, Joshua J. Breunig, Frank Pajonk, Thomas G. Graeber, Caius G. Radu, Heather Christofk, Robert M. Prins, Albert Lai, Linda M. Liau, Giovanni Coppola, Harley I. Kornblum
Published 2018-04-01

Tumor heterogeneity in VHL drives metastasis in clear cell renal cell carcinoma

by Junhui Hu, Ping Tan, Moe Ishihara, Nicholas A. Bayley, Shiruyeh Schokrpur, Jeremy G. Reynoso, Yangjun Zhang, Raymond J. Lim, Camelia Dumitras, Lu Yang, Steven M. Dubinett, Parmjit S. Jat, Jacques Van Snick, Jiaoti Huang, Arnold I. Chin, Robert M. Prins, Thomas G. Graeber, Hua Xu, Lily Wu
Published 2023-04-01

First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma

by Linda M. Liau, Keyoumars Ashkan, David D. Tran, Jian L. Campian, John E. Trusheim, Charles S. Cobbs, Jason A. Heth, Michael Salacz, Sarah Taylor, Stacy D. D’Andre, Fabio M. Iwamoto, Edward J. Dropcho, Yaron A. Moshel, Kevin A. Walter, Clement P. Pillainayagam, Robert Aiken, Rekha Chaudhary, Samuel A. Goldlust, Daniela A. Bota, Paul Duic, Jai Grewal, Heinrich Elinzano, Steven A. Toms, Kevin O. Lillehei, Tom Mikkelsen, Tobias Walbert, Steven R. Abram, Andrew J. Brenner, Steven Brem, Matthew G. Ewend, Simon Khagi, Jana Portnow, Lyndon J. Kim, William G. Loudon, Reid C. Thompson, David E. Avigan, Karen L. Fink, Francois J. Geoffroy, Scott Lindhorst, Jose Lutzky, Andrew E. Sloan, Gabriele Schackert, Dietmar Krex, Hans-Jorg Meisel, Julian Wu, Raphael P. Davis, Christopher Duma, Arnold B. Etame, David Mathieu, Santosh Kesari, David Piccioni, Manfred Westphal, David S. Baskin, Pamela Z. New, Michel Lacroix, Sven-Axel May, Timothy J. Pluard, Victor Tse, Richard M. Green, John L. Villano, Michael Pearlman, Kevin Petrecca, Michael Schulder, Lynne P. Taylor, Anthony E. Maida, Robert M. Prins, Timothy F. Cloughesy, Paul Mulholland, Marnix L. Bosch
Published 2018-05-01

Correction to: First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma

by Linda M. Liau, Keyoumars Ashkan, David D. Tran, Jian L. Campian, John E. Trusheim, Charles S. Cobbs, Jason A. Heth, Michael Salacz, Sarah Taylor, Stacy D. D’Andre, Fabio M. Iwamoto, Edward J. Dropcho, Yaron A. Moshel, Kevin A. Walter, Clement P. Pillainayagam, Robert Aiken, Rekha Chaudhary, Samuel A. Goldlust, Daniela A. Bota, Paul Duic, Jai Grewal, Heinrich Elinzano, Steven A. Toms, Kevin O. Lillehei, Tom Mikkelsen, Tobias Walbert, Steven R. Abram, Andrew J. Brenner, Steven Brem, Matthew G. Ewend, Simon Khagi, Jana Portnow, Lyndon J. Kim, William G. Loudon, Reid C. Thompson, David E. Avigan, Karen L. Fink, Francois J. Geoffroy, Scott Lindhorst, Jose Lutzky, Andrew E. Sloan, Gabriele Schackert, Dietmar Krex, Hans-Jorg Meisel, Julian Wu, Raphael P. Davis, Christopher Duma, Arnold B. Etame, David Mathieu, Santosh Kesari, David Piccioni, Manfred Westphal, David S. Baskin, Pamela Z. New, Michel Lacroix, Sven-Axel May, Timothy J. Pluard, Victor Tse, Richard M. Green, John L. Villano, Michael Pearlman, Kevin Petrecca, Michael Schulder, Lynne P. Taylor, Anthony E. Maida, Robert M. Prins, Timothy F. Cloughesy, Paul Mulholland, Marnix L. Bosch
Published 2018-06-01