Increased dermal collagen bundle alignment in systemic sclerosis is associated with a cell migration signature and role of Arhgdib in directed fibroblast migration on aligned ECMs.

by Lizhi Cao, Robert Lafyatis, Linda C Burkly
Published 2017-01-01

Transcriptomic characterization of lung pericytes in systemic sclerosis-associated pulmonary fibrosis

by Ludivine Renaud, Carole L. Wilson, Robert Lafyatis, Lynn M. Schnapp, Carol A. Feghali-Bostwick
Published 2024-06-01

The mycosis fungoides cutaneous microenvironment shapes dysfunctional cell trafficking, antitumor immunity, matrix interactions, and angiogenesis

by Alyxzandria M. Gaydosik, Connor J. Stonesifer, Tracy Tabib, Robert Lafyatis, Larisa J. Geskin, Patrizia Fuschiotti
Published 2023-10-01

Correction to: Single-cell transcriptome conservation in a comparative analysis of fresh and cryopreserved human skin tissue: pilot in localized scleroderma

by Emily Mirizio, Tracy Tabib, Xinjun Wang, Wei Chen, Christopher Liu, Robert Lafyatis, Heidi Jacobe, Kathryn S. Torok
Published 2021-04-01

Single-Cell Transcriptome Analysis Identifies Subclusters with Inflammatory Fibroblast Responses in Localized Scleroderma

by Giffin Werner, Anwesha Sanyal, Emily Mirizio, Theresa Hutchins, Tracy Tabib, Robert Lafyatis, Heidi Jacobe, Kathryn S. Torok
Published 2023-06-01

Single-cell transcriptome conservation in a comparative analysis of fresh and cryopreserved human skin tissue: pilot in localized scleroderma

by Emily Mirizio, Tracy Tabib, Xiao Wang, Wei Chen, Christopher Liu, Robert Lafyatis, Heidi Jacobe, Kathryn S. Torok
Published 2020-11-01

Disparate Interferon Signaling and Shared Aberrant Basaloid Cells in Single-Cell Profiling of Idiopathic Pulmonary Fibrosis and Systemic Sclerosis-Associated Interstitial Lung Dise...

by Eleanor Valenzi, Tracy Tabib, Anna Papazoglou, John Sembrat, Humberto E. Trejo Bittar, Mauricio Rojas, Robert Lafyatis
Published 2021-03-01

Limited systemic sclerosis patients with pulmonary arterial hypertension show biomarkers of inflammation and vascular injury.

by Sarah A Pendergrass, Everett Hayes, Giuseppina Farina, Raphael Lemaire, Harrison W Farber, Michael L Whitfield, Robert Lafyatis
Published 2010-08-01

Single Cell RNA Sequencing Identifies HSPG2 and APLNR as Markers of Endothelial Cell Injury in Systemic Sclerosis Skin

by Sokratis A. Apostolidis, Giuseppina Stifano, Tracy Tabib, Lisa M. Rice, Christina M. Morse, Bashar Kahaleh, Robert Lafyatis
Published 2018-10-01

Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension

by Didem Saygin, Tracy Tabib, Humberto E.T. Bittar, Eleanor Valenzi, John Sembrat, Stephen Y. Chan, Mauricio Rojas, Robert Lafyatis
Published 2020-02-01

HLA-B35 and dsRNA induce endothelin-1 via activation of ATF4 in human microvascular endothelial cells.

by Stefania Lenna, Izabela Chrobak, G Alessandra Farina, Fernando Rodriguez-Pascual, Santiago Lamas, Robert Lafyatis, Raffaella Scorza, Maria Trojanowska
Published 2013-01-01

A multicenter randomized, double-blind, placebo-controlled pilot study to assess the efficacy and safety of riociguat in systemic sclerosis-associated digital ulcers

by Vivek Nagaraja, Cathie Spino, Erica Bush, Pei-Suen Tsou, Robyn T. Domsic, Robert Lafyatis, Tracy Frech, Jessica K. Gordon, Virginia D. Steen, Dinesh Khanna
Published 2019-09-01

Early events marking lung fibroblast transition to profibrotic state in idiopathic pulmonary fibrosis

by Minxue Jia, Lorena Rosas, Maria G. Kapetanaki, Tracy Tabib, John Sebrat, Tamara Cruz, Anna Bondonese, Ana L. Mora, Robert Lafyatis, Mauricio Rojas, Panayiotis V. Benos
Published 2023-04-01

Increased frequency and compromised function of T regulatory cells in systemic sclerosis (SSc) is related to a diminished CD69 and TGFbeta expression.

by Timothy R D J Radstake, Lenny van Bon, Jasper Broen, Mark Wenink, Kim Santegoets, Yanhui Deng, Anila Hussaini, Robert Simms, William W Cruikshank, Robert Lafyatis
Published 2009-06-01

The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypes.

by Timothy R D J Radstake, Lenny van Bon, Jasper Broen, Anila Hussiani, Roger Hesselstrand, Dirk M Wuttge, Yanhui Deng, Robbert Simms, Erik Lubberts, Robert Lafyatis
Published 2009-06-01

Correction: Serum biomarker for diagnostic evaluation of pulmonary arterial hypertension in systemic sclerosis

by Lisa M. Rice, Julio C. Mantero, Eric A. Stratton, Rod Warburton, Kari Roberts, Nicholas Hill, Robert W. Simms, Robyn Domsic, Harrison W. Farber, Robert Lafyatis
Published 2022-05-01

Myofibroblast transcriptome indicates SFRP2hi fibroblast progenitors in systemic sclerosis skin

by Tracy Tabib, Mengqi Huang, Nina Morse, Anna Papazoglou, Rithika Behera, Minxue Jia, Melissa Bulik, Daisy E. Monier, Panayiotis V. Benos, Wei Chen, Robyn Domsic, Robert Lafyatis
Published 2021-07-01

536 Divergent cancer etiologies drive distinct B cell signatures and tertiary lymphoid structures in head and neck cancer

by Tracy Tabib, Robert Lafyatis, Seungwon Kim, Robert Ferris, Ayana Ruffin, Angen Liu, Sayali Onkar, Sheryl Kunning, Caleb Lampenfeld, Irina Abecassis, Zengbiao Qi, Ryan Soose, Umamaheswar Duvvuri, Steffi Oesterrich
Published 2020-11-01

A Role of Myocardin Related Transcription Factor-A (MRTF-A) in Scleroderma Related Fibrosis.

by Xu Shiwen, Richard Stratton, Joanna Nikitorowicz-Buniak, Bahja Ahmed-Abdi, Markella Ponticos, Christopher Denton, David Abraham, Ayuko Takahashi, Bela Suki, Matthew D Layne, Robert Lafyatis, Barbara D Smith
Published 2015-01-01

Tofacitinib blocks IFN-regulated biomarker genes in skin fibroblasts and keratinocytes in a systemic sclerosis trial

by Dinesh Khanna, Cristina Padilla, Lam C. Tsoi, Vivek Nagaraja, Puja P. Khanna, Tracy Tabib, J. Michelle Kahlenberg, Amber Young, Suiyuan Huang, Johann E. Gudjonsson, David A. Fox, Robert Lafyatis
Published 2022-09-01