Caenorhabditis elegans as a model system for studying non-cell-autonomous mechanisms in protein-misfolding diseases

by Carmen I. Nussbaum-Krammer, Richard I. Morimoto
Published 2014-01-01

Chaperone networks: Tipping the balance in protein folding diseases

by Cindy Voisine, Jesper Søndergaard Pedersen, Richard I. Morimoto
Published 2010-10-01

Destabilizing protein polymorphisms in the genetic background direct phenotypic expression of mutant SOD1 toxicity.

by Tali Gidalevitz, Thomas Krupinski, Susana Garcia, Richard I Morimoto
Published 2009-03-01

Neuronal reprograming of protein homeostasis by calcium-dependent regulation of the heat shock response.

by M Catarina Silva, Margarida D Amaral, Richard I Morimoto
Published 2013-08-01

Large-scale investigation of the reasons why potentially important genes are ignored.

by Thomas Stoeger, Martin Gerlach, Richard I Morimoto, Luís A Nunes Amaral
Published 2018-09-01

Reply to "Far away from the lamppost".

by Thomas Stoeger, Martin Gerlach, Richard I Morimoto, Luís A Nunes Amaral
Published 2018-12-01

Widespread Aggregation and Neurodegenerative Diseases Are Associated with Supersaturated Proteins

by Prajwal Ciryam, Gian Gaetano Tartaglia, Richard I. Morimoto, Christopher M. Dobson, Michele Vendruscolo
Published 2013-11-01

Identification of a tissue-selective heat shock response regulatory network.

by Eric Guisbert, Daniel M Czyz, Klaus Richter, Patrick D McMullen, Richard I Morimoto
Published 2013-04-01

Spreading of a prion domain from cell-to-cell by vesicular transport in Caenorhabditis elegans.

by Carmen I Nussbaum-Krammer, Kyung-Won Park, Liming Li, Ronald Melki, Richard I Morimoto
Published 2013-03-01

A genetic screening strategy identifies novel regulators of the proteostasis network.

by M Catarina Silva, Susan Fox, Monica Beam, Happy Thakkar, Margarida D Amaral, Richard I Morimoto
Published 2011-12-01

Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse during Aging

by Johnathan Labbadia, Renee M. Brielmann, Mario F. Neto, Yi-Fan Lin, Cole M. Haynes, Richard I. Morimoto
Published 2017-11-01

Macro-level modeling of the response of C. elegans reproduction to chronic heat stress.

by Patrick D McMullen, Erin Z Aprison, Peter B Winter, Luis A N Amaral, Richard I Morimoto, Ilya Ruvinsky
Published 2012-01-01

Target Identification of a Class of Pyrazolone Protein Aggregation Inhibitor Therapeutics for Amyotrophic Lateral Sclerosis

by Pathum M. Weerawarna, Isaac T. Schiefer, Pedro Soares, Susan Fox, Richard I. Morimoto, Rafael D. Melani, Neil L. Kelleher, Chi-Hao Luan, Richard B. Silverman
Published 2023-12-01

A Chaperome Subnetwork Safeguards Proteostasis in Aging and Neurodegenerative Disease

by Marc Brehme, Cindy Voisine, Thomas Rolland, Shinichiro Wachi, James H. Soper, Yitan Zhu, Kai Orton, Adriana Villella, Dan Garza, Marc Vidal, Hui Ge, Richard I. Morimoto
Published 2014-11-01

Hetero-oligomerization of TDP-43 carboxy-terminal fragments with cellular proteins contributes to proteotoxicity

by Akira Kitamura, Ai Fujimoto, Rei Kawashima, Yidan Lyu, Kotetsu Sasaki, Yuta Hamada, Kanami Moriya, Ayumi Kurata, Kazuho Takahashi, Reneé Brielmann, Laura C. Bott, Richard I. Morimoto, Masataka Kinjo
Published 2024-06-01

Modulation of the maladaptive stress response to manage diseases of protein folding.

by Daniela Martino Roth, Darren M Hutt, Jiansong Tong, Marion Bouchecareilh, Ning Wang, Theo Seeley, Johanna F Dekkers, Jeffrey M Beekman, Dan Garza, Lawrence Drew, Eliezer Masliah, Richard I Morimoto, William E Balch
Published 2014-11-01

A metastable subproteome underlies inclusion formation in muscle proteinopathies

by Prajwal Ciryam, Matthew Antalek, Fernando Cid, Gian Gaetano Tartaglia, Christopher M. Dobson, Anne-Katrin Guettsches, Britta Eggers, Matthias Vorgerd, Katrin Marcus, Rudolf A. Kley, Richard I. Morimoto, Michele Vendruscolo, Conrad C. Weihl
Published 2019-12-01