Logistic regression has similar performance to optimised machine learning algorithms in a clinical setting: application to the discrimination between type 1 and type 2 diabetes in...

by Anita L. Lynam, John M. Dennis, Katharine R. Owen, Richard A. Oram, Angus G. Jones, Beverley M. Shields, Lauric A. Ferrat
Published 2020-06-01

Estimating disease prevalence in large datasets using genetic risk scores

by Benjamin D. Evans, Piotr Słowiński, Andrew T. Hattersley, Samuel E. Jones, Seth Sharp, Robert A. Kimmitt, Michael N. Weedon, Richard A. Oram, Krasimira Tsaneva-Atanasova, Nicholas J. Thomas
Published 2021-11-01

Analysis of serum Hsp90 as a potential biomarker of β cell autoimmunity in type 1 diabetes.

by Gail J Ocaña, Emily K Sims, Renecia A Watkins, Susanne Ragg, Kieren J Mather, Richard A Oram, Raghavendra G Mirmira, Linda A DiMeglio, Janice S Blum, Carmella Evans-Molina
Published 2019-01-01

IgA Nephropathy Genetic Risk Score to Estimate the Prevalence of IgA Nephropathy in UK Biobank

by Kittiya Sukcharoen, Seth A. Sharp, Nicholas J. Thomas, Robert A. Kimmitt, Jamie Harrison, Coralie Bingham, Monika Mozere, Michael N. Weedon, Jessica Tyrrell, Jonathan Barratt, Daniel P. Gale, Richard A. Oram
Published 2020-10-01

Applying a genetic risk score model to enhance prediction of future multiple sclerosis diagnosis at first presentation with optic neuritis

by Pavel Loginovic, Feiyi Wang, Jiang Li, Lauric Ferrat, Uyenlinh L. Mirshahi, H. Shanker Rao, Axel Petzold, Jessica Tyrrell, Harry D. Green, Michael N. Weedon, Andrea Ganna, Tiinamaija Tuomi, David J. Carey, UKBB Eye & Vision Consortium, FinnGen, Geisinger-Regeneron DiscovEHR Collaboration, Richard A. Oram, Tasanee Braithwaite
Published 2024-02-01

Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children.

by Ezio Bonifacio, Andreas Beyerlein, Markus Hippich, Christiane Winkler, Kendra Vehik, Michael N Weedon, Michael Laimighofer, Andrew T Hattersley, Jan Krumsiek, Brigitte I Frohnert, Andrea K Steck, William A Hagopian, Jeffrey P Krischer, Åke Lernmark, Marian J Rewers, Jin-Xiong She, Jorma Toppari, Beena Akolkar, Richard A Oram, Stephen S Rich, Anette-G Ziegler, TEDDY Study Group
Published 2018-04-01

Disease-modifying therapies and features linked to treatment response in type 1 diabetes prevention: a systematic review

by Jamie L. Felton, Kurt J. Griffin, Richard A. Oram, Cate Speake, S. Alice Long, Suna Onengut-Gumuscu, Stephen S. Rich, Gabriela S. F. Monaco, Carmella Evans-Molina, Linda A. DiMeglio, Heba M. Ismail, Andrea K. Steck, Dana Dabelea, Randi K. Johnson, Marzhan Urazbayeva, Stephen Gitelman, John M. Wentworth, Maria J. Redondo, Emily K. Sims, ADA/EASD PMDI
Published 2023-10-01

Islet autoantibodies as precision diagnostic tools to characterize heterogeneity in type 1 diabetes: a systematic review

by Jamie L. Felton, Maria J. Redondo, Richard A. Oram, Cate Speake, S. Alice Long, Suna Onengut-Gumuscu, Stephen S. Rich, Gabriela S. F. Monaco, Arianna Harris-Kawano, Dianna Perez, Zeb Saeed, Benjamin Hoag, Rashmi Jain, Carmella Evans-Molina, Linda A. DiMeglio, Heba M. Ismail, Dana Dabelea, Randi K. Johnson, Marzhan Urazbayeva, John M. Wentworth, Kurt J. Griffin, Emily K. Sims, On behalf of the ADA/EASD PMDI
Published 2024-04-01