C8ORF88: A Novel eIF4E-Binding Protein

by Lauren Pugsley, Sai Kiran Naineni, Mehdi Amiri, Akiko Yanagiya, Regina Cencic, Nahum Sonenberg, Jerry Pelletier
Published 2023-11-01

Protospacer adjacent motif (PAM)-distal sequences engage CRISPR Cas9 DNA target cleavage.

by Regina Cencic, Hisashi Miura, Abba Malina, Francis Robert, Sylvain Ethier, T Martin Schmeing, Josée Dostie, Jerry Pelletier
Published 2014-01-01

CRISPR-Mediated Drug-Target Validation Reveals Selective Pharmacological Inhibition of the RNA Helicase, eIF4A

by Jennifer Chu, Gabriela Galicia-Vázquez, Regina Cencic, John R. Mills, Alexandra Katigbak, John A. Porco Jr., Jerry Pelletier
Published 2016-06-01

Haploinsufficiency of the ESCRT Component HD-PTP Predisposes to Cancer

by Sanaz Manteghi, Marie-Claude Gingras, Dmitri Kharitidi, Luc Galarneau, Maud Marques, Ming Yan, Regina Cencic, Francis Robert, Marilène Paquet, Michael Witcher, Jerry Pelletier, Arnim Pause
Published 2016-05-01

Selective pharmacological targeting of a DEAD box RNA helicase.

by Lisa Lindqvist, Monika Oberer, Mikhail Reibarkh, Regina Cencic, Marie-Eve Bordeleau, Emily Vogt, Assen Marintchev, Junichi Tanaka, Francois Fagotto, Michael Altmann, Gerhard Wagner, Jerry Pelletier
Published 2008-02-01

Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol.

by Regina Cencic, Marilyn Carrier, Gabriela Galicia-Vázquez, Marie-Eve Bordeleau, Rami Sukarieh, Annie Bourdeau, Brigitte Brem, Jose G Teodoro, Harald Greger, Michel L Tremblay, John A Porco, Jerry Pelletier
Published 2009-01-01

A forward genetic screen identifies modifiers of rocaglate responsiveness

by Leo Shen, Lauren Pugsley, Regina Cencic, HanChen Wang, Francis Robert, Sai Kiran Naineni, Ananya Sahni, Geneviève Morin, Wenhan Zhang, Anastasia Nijnik, John A. Porco, David Langlais, Sidong Huang, Jerry Pelletier
Published 2021-09-01

Eukaryotic Translation Initiation Factor 4AI: A Potential Novel Target in Neuroblastoma

by Christina Skofler, Florian Kleinegger, Stefanie Krassnig, Anna Maria Birkl-Toeglhofer, Georg Singer, Holger Till, Martin Benesch, Regina Cencic, John A. Porco, Jerry Pelletier, Christoph Castellani, Andrea Raicht, Ewa Izycka-Swieszewska, Piotr Czapiewski, Johannes Haybaeck
Published 2021-02-01

Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F

by Jennifer Chu, Wenhan Zhang, Regina Cencic, Patrick B.F. O’Connor, Francis Robert, William G. Devine, Asher Selznick, Thomas Henkel, William C. Merrick, Lauren E. Brown, Pavel V. Baranov, John A. Porco, Jr., Jerry Pelletier
Published 2020-02-01

CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary

by Yibo Xue, Brian Meehan, Elizabeth Macdonald, Sriram Venneti, Xue Qing D. Wang, Leora Witkowski, Petar Jelinic, Tim Kong, Daniel Martinez, Geneviève Morin, Michelle Firlit, Atefeh Abedini, Radia M. Johnson, Regina Cencic, Jay Patibandla, Hongbo Chen, Andreas I. Papadakis, Aurelie Auguste, Iris de Rink, Ron M. Kerkhoven, Nicholas Bertos, Walter H. Gotlieb, Blaise A. Clarke, Alexandra Leary, Michael Witcher, Marie-Christine Guiot, Jerry Pelletier, Josée Dostie, Morag Park, Alexander R. Judkins, Ralf Hass, Douglas A. Levine, Janusz Rak, Barbara Vanderhyden, William D. Foulkes, Sidong Huang
Published 2019-02-01

Selective Pharmacological Targeting of a DEAD Box RNA Helicase

by Lindqvist, Lisa, Oberer, Monika, Reibarkh, Mikhail, Cencic, Regina, Bordeleau, Marie-Eve, Vogt, Emily, Marintchev, Assen, Tanaka, Junichi, Fagotto, Francois, Altmann, Michael, Pelletier, Jerry, Wagner, Gerhard
Published 2010