Tracking tumor evolution one-cell-at-a-time

by Ankur Sharma, Ramanuj DasGupta
Published 2019-05-01

miR-582-5p Is a Tumor Suppressor microRNA Targeting the Hippo-YAP/TAZ Signaling Pathway in Non-Small Cell Lung Cancer

by Bowen Zhu, Mitheera V, Megan Finch-Edmondson, Yaelim Lee, Yue Wan, Marius Sudol, Ramanuj DasGupta
Published 2021-02-01

Predicting heterogeneity in clone-specific therapeutic vulnerabilities using single-cell transcriptomic signatures

by Chayaporn Suphavilai, Shumei Chia, Ankur Sharma, Lorna Tu, Rafael Peres Da Silva, Aanchal Mongia, Ramanuj DasGupta, Niranjan Nagarajan
Published 2021-12-01

An AI‐assisted integrated, scalable, single‐cell phenomic‐transcriptomic platform to elucidate intratumor heterogeneity against immune response

by Christopher P. Tostado, Lucas Xian Da Ong, Joel Jia Wei Heng, Carlo Miccolis, Shumei Chia, Justine Jia Wen Seow, Yi‐Chin Toh, Ramanuj DasGupta
Published 2024-03-01

LncRNA SFTA1P mediates positive feedback regulation of the Hippo-YAP/TAZ signaling pathway in non-small cell lung cancer

by Bowen Zhu, Megan Finch-Edmondson, Kim Whye Leong, Xiaoqian Zhang, Mitheera V., Quy Xiao Xuan Lin, Yaelim Lee, Wei Ting Ng, Huili Guo, Yue Wan, Marius Sudol, Ramanuj DasGupta
Published 2021-11-01

Molecular docking-aided identification of small molecule inhibitors targeting β-catenin-TCF4 interaction

by Joo-Leng Low, Weina Du, Tenzin Gocha, Gokce Oguz, Xiaoqian Zhang, Ming Wei Chen, Srdan Masirevic, Daniel Guo Rong Yim, Iain Bee Huat Tan, Adaikalavan Ramasamy, Hao Fan, Ramanuj DasGupta
Published 2021-06-01

The chromatin structuring protein HMGA2 influences human subtelomere stability and cancer chemosensitivity.

by Syed Moiz Ahmed, Priya Dharshana Ramani, Stephen Qi Rong Wong, Xiaodan Zhao, Roland Ivanyi-Nagy, Tang Choong Leong, Clarinda Chua, Zhizhong Li, Hannes Hentze, Iain BeeHuat Tan, Jie Yan, Ramanuj DasGupta, Peter Dröge
Published 2019-01-01

Single-Cell RNA-seq Reveals Angiotensin-Converting Enzyme 2 and Transmembrane Serine Protease 2 Expression in TROP2+ Liver Progenitor Cells: Implications in Coronavirus Disease 201...

by Justine Jia Wen Seow, Rhea Pai, Archita Mishra, Edwin Shepherdson, Tony Kiat Hon Lim, Brian K. P. Goh, Jerry K. Y. Chan, Pierce K. H. Chow, Florent Ginhoux, Florent Ginhoux, Florent Ginhoux, Ramanuj DasGupta, Ankur Sharma, Ankur Sharma, Ankur Sharma
Published 2021-04-01

Hepatocyte-macrophage crosstalk via the PGRN-EGFR axis modulates ADAR1-mediated immunity in the liver

by Wei Liang Gan, Xi Ren, Vanessa Hui En Ng, Larry Ng, Yangyang Song, Vincent Tano, Jian Han, Omer An, Jinghe Xie, Bryan Y.L. Ng, Daryl Jin Tai Tay, Sze Jing Tang, Haoqing Shen, Shruti Khare, Kelvin Han Chung Chong, Dan Yock Young, Bin Wu, Ramanuj DasGupta, Leilei Chen
Published 2024-07-01

Longitudinal single-cell RNA sequencing of patient-derived primary cells reveals drug-induced infidelity in stem cell hierarchy

by Ankur Sharma, Elaine Yiqun Cao, Vibhor Kumar, Xiaoqian Zhang, Hui Sun Leong, Angeline Mei Lin Wong, Neeraja Ramakrishnan, Muhammad Hakimullah, Hui Min Vivian Teo, Fui Teen Chong, Shumei Chia, Matan Thangavelu Thangavelu, Xue Lin Kwang, Ruta Gupta, Jonathan R. Clark, Giridharan Periyasamy, N. Gopalakrishna Iyer, Ramanuj DasGupta
Published 2018-11-01

A chemical genetic screen identifies Aurora kinases as a therapeutic target in EGFR T790M negative, gefitinib-resistant head and neck squamous cell carcinoma (HNSCC)

by Joo-Leng Low, Dawn Pingxi Lau, Xiaoqian Zhang, Xue-Lin Kwang, Neha Rohatgi, Jane Vin Chan, Fui-Teen Chong, Stephen Qi Rong Wong, Hui-Sun Leong, Matan Thangavelu Thangavelu, Shivaji Rikka, Anders Martin Jacobsen Skanderup, Daniel Shao Weng Tan, Giridharan Periyasamy, Judice Lie Yong Koh, N Gopalakrishna Iyer, Ramanuj DasGupta
Published 2021-02-01

Corrigendum to ‘A chemical genetic screen identifies Aurora kinases as a therapeutic target in EGFR T790M negative, gefitinib-resistant head and neck squamous cell carcinoma (HNSCC...

by Joo-Leng Low, Dawn Pingxi Lau, Xiaoqian Zhang, Xue-Lin Kwang, Neha Rohatgi, Jane Vin Chan, Fui-Teen Chong, Stephen Qi Rong Wong, Hui-Sun Leong, Matan Thangavelu Thangavelu, Shivaji Rikka, Anders Martin Jacobsen Skanderup, Daniel Shao Weng Tan, Giridharan Periyasamy, Judice Lie Yong Koh, N Gopalakrishna Iyer, Ramanuj DasGupta
Published 2021-04-01

DUSP16 promotes cancer chemoresistance through regulation of mitochondria-mediated cell death

by Heng Boon Low, Zhen Lim Wong, Bangyuan Wu, Li Ren Kong, Chin Wen Png, Yik-Lam Cho, Chun-Wei Li, Fengchun Xiao, Xuan Xin, Henry Yang, Jia Min Loo, Fiona Yi Xin Lee, Iain Bee Huat Tan, Ramanuj DasGupta, Han-Ming Shen, Herbert Schwarz, Nicholas R. J. Gascoigne, Boon Cher Goh, Xiaohong Xu, Yongliang Zhang
Published 2021-04-01

Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time

by Shumei Chia, Joo-Leng Low, Xiaoqian Zhang, Xue-Lin Kwang, Fui-Teen Chong, Ankur Sharma, Denis Bertrand, Shen Yon Toh, Hui-Sun Leong, Matan T. Thangavelu, Jacqueline S. G. Hwang, Kok-Hing Lim, Thakshayeni Skanthakumar, Hiang-Khoon Tan, Yan Su, Siang Hui Choo, Hannes Hentze, Iain B. H. Tan, Alexander Lezhava, Patrick Tan, Daniel S. W. Tan, Giridharan Periyasamy, Judice L. Y. Koh, N. Gopalakrishna Iyer, Ramanuj DasGupta
Published 2017-09-01

CD38 marks the exhausted CD8+ tissue-resident memory T cells in hepatocellular carcinoma

by Marie J. Y. Reolo, Masayuki Otsuka, Justine Jia Wen Seow, Joycelyn Lee, Yun Hua Lee, Phuong H. D. Nguyen, Chun Jye Lim, Martin Wasser, Camillus Chua, Tony K. H. Lim, Wei Qiang Leow, Alexander Chung, Brian K. P. Goh, Brian K. P. Goh, Pierce K. H. Chow, Pierce K. H. Chow, Pierce K. H. Chow, Ramanuj DasGupta, Joe Poh Sheng Yeong, Valerie Chew
Published 2023-06-01

A comparative study of tumour-on-chip models with patient-derived xenografts for predicting chemotherapy efficacy in colorectal cancer patients

by Louis Jun Ye Ong, Louis Jun Ye Ong, Louis Jun Ye Ong, Louis Jun Ye Ong, Shumei Chia, Stephen Qi Rong Wong, Stephen Qi Rong Wong, Stephen Qi Rong Wong, Xiaoqian Zhang, Huiwen Chua, Jia Min Loo, Wei Yong Chua, Clarinda Chua, Emile Tan, Hannes Hentze, Iain Beehuat Tan, Iain Beehuat Tan, Iain Beehuat Tan, Ramanuj DasGupta, Yi-Chin Toh, Yi-Chin Toh, Yi-Chin Toh, Yi-Chin Toh
Published 2022-08-01

Trajectory of immune evasion and cancer progression in hepatocellular carcinoma

by Phuong H. D. Nguyen, Martin Wasser, Chong Teik Tan, Chun Jye Lim, Hannah L. H. Lai, Justine Jia Wen Seow, Ramanuj DasGupta, Cheryl Z. J. Phua, Siming Ma, Jicheng Yang, Sheena D/O Suthen, Wai Leong Tam, Tony K. H. Lim, Joe Yeong, Wei Qiang Leow, Yin Huei Pang, Gwyneth Soon, Tracy Jiezhen Loh, Wei Keat Wan, Chung Yip Chan, Peng Chung Cheow, Han Chong Toh, Alfred Kow, Yock Young Dan, Juinn Huar Kam, Shridhar Iyer, Krishnakumar Madhavan, Alexander Chung, Glenn K. Bonney, Brian K. P. Goh, Naiyang Fu, Victor C. Yu, Weiwei Zhai, Salvatore Albani, Pierce K. H. Chow, Valerie Chew
Published 2022-03-01

Notch Modulates Wnt Signalling by Associating With Armadillo/ -Catenin and Regulating Its Transcriptional Activity

by Hayward, Penny, Brennan, Keith, Sanders, Phil, Balayo, Tina, DasGupta, Ramanuj, Perrimon, Norbert, Martinez Arias, Alfonso
Published 2021