Involvement of the TGF-β Signaling Pathway in the Development of YAP-Driven Osteosarcoma Lung Metastasis

by Sarah Morice, Geoffroy Danieau, Robel Tesfaye, Mathilde Mullard, Régis Brion, Régis Brion, Maryne Dupuy, Benjamin Ory, Bénédicte Brounais-Le Royer, Isabelle Corre, Françoise Redini, Franck Verrecchia
Published 2021-10-01

LIM Kinases in Osteosarcoma Development

by Régis Brion, Laura Regnier, Mathilde Mullard, Jérome Amiaud, Françoise Rédini, Franck Verrecchia
Published 2021-12-01

Exposure of primary bone tumor-associated stromal cells to multi-pesticides at low doses and paracrine effects on osteoclast differentiation

by Valérie Trichet, Louis-Romée Le Nail, Régis Brion, Françoise Rédini, François Vallette, Olivier Hérault, Christophe Olivier
Published 2020-10-01

Imatinib mesylate exerts anti-proliferative effects on osteosarcoma cells and inhibits the tumour growth in immunocompetent murine models.

by Bérengère Gobin, Gatien Moriceau, Benjamin Ory, Céline Charrier, Régis Brion, Frederic Blanchard, Françoise Redini, Dominique Heymann
Published 2014-01-01

Pro-inflammatory effects of human apatite crystals extracted from patients suffering from calcific tendinopathy

by Julien Herman, Benoit Le Goff, Julien De Lima, Régis Brion, Catherine Chevalier, Frédéric Blanchard, Christelle Darrieutort-Laffite
Published 2021-04-01

TRAIL-Based Therapies Efficacy in Pediatric Bone Tumors Models Is Modulated by TRAIL Non-Apoptotic Pathway Activation via RIPK1 Recruitment

by Régis Brion, Malika Gantier, Kevin Biteau, Julien Taurelle, Bénédicte Brounais-Le Royer, Franck Verrecchia, Françoise Rédini, Romain Guiho
Published 2022-11-01

The YAP/TEAD Axis as a New Therapeutic Target in Osteosarcoma: Effect of Verteporfin and CA3 on Primary Tumor Growth

by Sarah Morice, Mathilde Mullard, Regis Brion, Maryne Dupuy, Sarah Renault, Robel Tesfaye, Bénédicte Brounais-Le Royer, Benjamin Ory, Françoise Redini, Franck Verrecchia
Published 2020-12-01

Apoptotic mesenchymal stromal cells support osteoclastogenesis while inhibiting multinucleated giant cells formation in vitro

by Paul Humbert, Meadhbh Á. Brennan, Julien De Lima, Régis Brion, Annie Adrait, Céline Charrier, Bénédicte Brulin, Valérie Trichet, Yohann Couté, Frédéric Blanchard, Pierre Layrolle
Published 2021-06-01

Jaw osteosarcoma models in mice: first description

by Hélios Bertin, Romain Guilho, Régis Brion, Jérôme Amiaud, Séverine Battaglia, Anne Moreau, Anne Brouchet-Gomez, Julie Longis, Benoit Piot, Dominique Heymann, Pierre Corre, Françoise Rédini
Published 2019-02-01

ICG-001, an Inhibitor of the β-Catenin and cAMP Response Element-Binding Protein Dependent Gene Transcription, Decreases Proliferation but Enhances Migration of Osteosarcoma Cells

by Geoffroy Danieau, Sarah Morice, Sarah Renault, Régis Brion, Kevin Biteau, Jérôme Amiaud, Marie Cadé, Dominique Heymann, Frédéric Lézot, Franck Verrecchia, Françoise Rédini, Bénédicte Brounais-Le Royer
Published 2021-05-01

Osteoprotegerin, pericytes and bone-like vascular calcification are associated with carotid plaque stability.

by Jean-Michel Davaine, Thibaut Quillard, Régis Brion, Olivier Lapérine, Béatrice Guyomarch, Thierry Merlini, Mathias Chatelais, Florian Guilbaud, Meadhbh Áine Brennan, Céline Charrier, Dominique Heymann, Yann Gouëffic, Marie-Françoise Heymann
Published 2014-01-01

The Intrinsic and Extrinsic Implications of RANKL/RANK Signaling in Osteosarcoma: From Tumor Initiation to Lung Metastases

by Benjamin Navet, Kosei Ando, Jorge William Vargas-Franco, Régis Brion, Jérome Amiaud, Kanji Mori, Hideo Yagita, Christopher G. Mueller, Franck Verrecchia, Clotilde Dumars, Marie-Françoise Heymann, Dominique Heymann, Frédéric Lézot
Published 2018-10-01

Overexpression of the Ubiquitin Specific Proteases USP43, USP41, USP27x and USP6 in Osteosarcoma Cell Lines: Inhibition of Osteosarcoma Tumor Growth and Lung Metastasis Development...

by Mélanie Lavaud, Mathilde Mullard, Robel Tesfaye, Jérôme Amiaud, Mélanie Legrand, Geoffroy Danieau, Régis Brion, Sarah Morice, Laura Regnier, Maryne Dupuy, Bénédicte Brounais-Le Royer, François Lamoureux, Benjamin Ory, Françoise Rédini, Franck Verrecchia
Published 2021-08-01

Sonic Hedgehog Signature in Pediatric Primary Bone Tumors: Effects of the GLI Antagonist GANT61 on Ewing’s Sarcoma Tumor Growth

by Mathilde Mullard, Marie Cadé, Sarah Morice, Maryne Dupuy, Geoffroy Danieau, Jérome Amiaud, Sarah Renault, Frédéric Lézot, Régis Brion, Rose Anne Thepault, Benjamin Ory, François Lamoureux, Isabelle Corre, Bénédicte Brounais-LeRoyer, Françoise Rédini, Franck Verrecchia
Published 2020-11-01

Characterization of Macrophages and Osteoclasts in the Osteosarcoma Tumor Microenvironment at Diagnosis: New Perspective for Osteosarcoma Treatment?

by Anne Gomez-Brouchet, Julia Gilhodes, Nathalie Van Acker, Regis Brion, Corinne Bouvier, Pauline Assemat, Nathalie Gaspar, Sebastien Aubert, Jean-Marc Guinebretiere, Beatrice Marie, Frederique Larousserie, Natacha Entz-Werlé, Gonzague De Pinieux, Eric Mascard, Francois Gouin, Pierre Brousset, Marie-Dominique Tabone, Marta Jimenez, Marie-Cecile Le Deley, Jean-Yves Blay, Laurence Brugieres, Sophie Piperno-Neumann, Francoise Rédini
Published 2021-01-01