Improved xenobiotic metabolism and reduced susceptibility to cancer in gluten-sensitive macaques upon introduction of a gluten-free diet.

by Karol Sestak, Lauren Conroy, Pyone P Aye, Smriti Mehra, Gaby G Doxiadis, Deepak Kaushal
Published 2011-04-01

Enhanced IL-17 Producing and Maintained Cytolytic Effector Functions of Gut Mucosal CD161⁺CD8⁺ T Cells in SIV-Infected Rhesus Macaques

by Siva Thirugnanam, Edith M. Walker, Faith Schiro, Pyone P. Aye, Jay Rappaport, Namita Rout
Published 2023-09-01

Focused examination of the intestinal epithelium reveals transcriptional signatures consistent with disturbances in enterocyte maturation and differentiation during the course of S...

by Mahesh Mohan, Deepak Kaushal, Pyone P Aye, Xavier Alvarez, Ronald S Veazey, Andrew A Lackner
Published 2013-01-01

Focused examination of the intestinal lamina propria yields greater molecular insight into mechanisms underlying SIV induced immune dysfunction.

by Mahesh Mohan, Deepak Kaushal, Pyone P Aye, Xavier Alvarez, Ronald S Veazey, Andrew A Lackner
Published 2012-01-01

The Effects of Reduced Gluten Barley Diet on Humoral and Cell-Mediated Systemic Immune Responses of Gluten-Sensitive Rhesus Macaques

by Karol Sestak, Hazel Thwin, Jason Dufour, Pyone P. Aye, David X. Liu, Charles P. Moehs
Published 2015-03-01

Dietary Gluten-Induced Gut Dysbiosis Is Accompanied by Selective Upregulation of microRNAs with Intestinal Tight Junction and Bacteria-Binding Motifs in Rhesus Macaque Model of Cel...

by Mahesh Mohan, Cheryl-Emiliane T. Chow, Caitlin N. Ryan, Luisa S. Chan, Jason Dufour, Pyone P. Aye, James Blanchard, Charles P. Moehs, Karol Sestak
Published 2016-10-01

Supplementation of Reduced Gluten Barley Diet with Oral Prolyl Endopeptidase Effectively Abrogates Enteropathy-Associated Changes in Gluten-Sensitive Macaques

by Karol Sestak, Hazel Thwin, Jason Dufour, David X. Liu, Xavier Alvarez, David Laine, Adam Clarke, Anthony Doyle, Pyone P. Aye, James Blanchard, Charles P. Moehs
Published 2016-06-01

Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleases.

by Craig B Wilen, Jianbin Wang, John C Tilton, Jeffrey C Miller, Kenneth A Kim, Edward J Rebar, Scott A Sherrill-Mix, Sean C Patro, Anthony J Secreto, Andrea P O Jordan, Gary Lee, Joshua Kahn, Pyone P Aye, Bruce A Bunnell, Andrew A Lackner, James A Hoxie, Gwenn A Danet-Desnoyers, Frederic D Bushman, James L Riley, Philip D Gregory, Carl H June, Michael C Holmes, Robert W Doms
Published 2011-04-01

The pigtail macaque (Macaca nemestrina) model of COVID-19 reproduces diverse clinical outcomes and reveals new and complex signatures of disease.

by Alexandra Melton, Lara A Doyle-Meyers, Robert V Blair, Cecily Midkiff, Hunter J Melton, Kasi Russell-Lodrigue, Pyone P Aye, Faith Schiro, Marissa Fahlberg, Dawn Szeltner, Skye Spencer, Brandon J Beddingfield, Kelly Goff, Nadia Golden, Toni Penney, Breanna Picou, Krystle Hensley, Kristin E Chandler, Jessica A Plante, Kenneth S Plante, Scott C Weaver, Chad J Roy, James A Hoxie, Hongmei Gao, David C Montefiori, Joseph L Mankowski, Rudolf P Bohm, Jay Rappaport, Nicholas J Maness
Published 2021-12-01

A cellular trafficking signal in the SIV envelope protein cytoplasmic domain is strongly selected for in pathogenic infection.

by Scott P Lawrence, Samra E Elser, Workineh Torben, Robert V Blair, Bapi Pahar, Pyone P Aye, Faith Schiro, Dawn Szeltner, Lara A Doyle-Meyers, Beth S Haggarty, Andrea P O Jordan, Josephine Romano, George J Leslie, Xavier Alvarez, David H O'Connor, Roger W Wiseman, Christine M Fennessey, Yuan Li, Michael Piatak, Jeffrey D Lifson, Celia C LaBranche, Andrew A Lackner, Brandon F Keele, Nicholas J Maness, Mark Marsh, James A Hoxie
Published 2022-06-01

A combined adjuvant approach primes robust germinal center responses and humoral immunity in non-human primates

by Ivy Phung, Kristen A. Rodrigues, Ester Marina-Zárate, Laura Maiorino, Bapi Pahar, Wen-Hsin Lee, Mariane Melo, Amitinder Kaur, Carolina Allers, Marissa Fahlberg, Brooke F. Grasperge, Jason P. Dufour, Faith Schiro, Pyone P. Aye, Paul G. Lopez, Jonathan L. Torres, Gabriel Ozorowski, Saman Eskandarzadeh, Michael Kubitz, Erik Georgeson, Bettina Groschel, Rebecca Nedellec, Michael Bick, Katarzyna Kaczmarek Michaels, Hongmei Gao, Xiaoying Shen, Diane G. Carnathan, Guido Silvestri, David C. Montefiori, Andrew B. Ward, Lars Hangartner, Ronald S. Veazey, Dennis R. Burton, William R. Schief, Darrell J. Irvine, Shane Crotty
Published 2023-11-01

Fetal demise and failed antibody therapy during Zika virus infection of pregnant macaques

by Diogo M. Magnani, Thomas F. Rogers, Nicholas J. Maness, Nathan D. Grubaugh, Nathan Beutler, Varian K. Bailey, Lucas Gonzalez-Nieto, Martin J. Gutman, Núria Pedreño-Lopez, Jaclyn M. Kwal, Michael J. Ricciardi, Tereance A. Myers, Justin G. Julander, Rudolf P. Bohm, Margaret H. Gilbert, Faith Schiro, Pyone P. Aye, Robert V. Blair, Mauricio A. Martins, Kathrine P. Falkenstein, Amitinder Kaur, Christine L. Curry, Esper G. Kallas, Ronald C. Desrosiers, Pascal J. Goldschmidt-Clermont, Stephen S. Whitehead, Kristian G. Andersen, Myrna C. Bonaldo, Andrew A. Lackner, Antonito T. Panganiban, Dennis R. Burton, David I. Watkins
Published 2018-04-01