Findings from precision oncology in the clinic: rare, novel variants are a significant contributor to scaling molecular diagnostics

by Kenneth D. Doig, Christopher G. Love, Thomas Conway, Andrei Seleznev, David Ma, Andrew Fellowes, Piers Blombery, Stephen B. Fox
Published 2022-03-01

Canary: an atomic pipeline for clinical amplicon assays

by Kenneth D. Doig, Jason Ellul, Andrew Fellowes, Ella R. Thompson, Georgina Ryland, Piers Blombery, Anthony T. Papenfuss, Stephen B. Fox
Published 2017-12-01

JAFFAL: detecting fusion genes with long-read transcriptome sequencing

by Nadia M. Davidson, Ying Chen, Teresa Sadras, Georgina L. Ryland, Piers Blombery, Paul G. Ekert, Jonathan Göke, Alicia Oshlack
Published 2022-01-01

Favorable outcomes of DDX41‐mutated myelodysplastic syndrome and low blast count acute myeloid leukemia treated with azacitidine ± lenalidomide

by Ing S. Tiong, William S. Stevenson, Meaghan Wall, Yan Zhuang Yap, John F. Seymour, Melita Kenealy, Piers Blombery, the Australasian Leukaemia & Lymphoma Group
Published 2023-11-01

Transient, flexible gene editing in zebrafish neutrophils and macrophages for determination of cell-autonomous functions

by Abdulsalam I. Isiaku, Zuobing Zhang, Vahid Pazhakh, Harriet R. Manley, Ella R. Thompson, Lucy C. Fox, Satwica Yerneni, Piers Blombery, Graham J. Lieschke
Published 2021-07-01

Reactivation of DNA viruses in association with histone deacetylase inhibitor therapy: a case series report

by David Ritchie, Richard L. Piekarz, Piers Blombery, Laszlo J. Karai, Stefania Pittaluga, Elaine S. Jaffe, Mark Raffeld, John E. Janik, H. Miles Prince, Susan E. Bates
Published 2009-11-01

Systemic diffuse large B-cell lymphoma involving the central nervous system have high rates of defective antigen presentation and immune surveillance

by Joel Wight, Piers Blombery, Jennifer Lickiss, Melinda Burgess, Clare Gould, Adrian Minson, Fiona Swain, Muhammed B. Sabdia, Maher K. Gandhi, Andrew Birchley, Colm Keane, Eliza A Hawkes
Published 2024-03-01

Whole exome sequencing reveals activating JAK1 and STAT3 mutations in breast implant-associated anaplastic large cell lymphoma anaplastic large cell lymphoma

by Piers Blombery, Ella R. Thompson, Kate Jones, Gisela Mir Arnau, Stephen Lade, John F. Markham, Jason Li, Anand Deva, Ricky W. Johnstone, Amit Khot, H. Miles Prince, David Westerman
Published 2016-09-01

Rapid and Durable Complete Remission of Refractory AITL with Azacitidine Treatment in Absence of TET2 Mutation or Concurrent MDS

by Gareth P. Gregory, Michael Dickinson, Costas K. Yannakou, Jonathan Wong, Piers Blombery, Greg Corboy, Lev Kats, Tim M.E. Crozier, Beena Kumar, H. Miles Prince, Stephen S. Opat, Jake Shortt
Published 2019-04-01

Persistence of UBTF tandem duplications in remission in acute myeloid leukaemia

by Sean Harrop, Phillip C. Nguyen, David Byrne, Clarissa Wilson, Georgina L. Ryland, Tamia Nguyen, Mary Ann Anderson, Seong Lin Khaw, Michelle Martin, Ing Soo Tiong, Elaine Sanij, Piers Blombery
Published 2023-11-01

Clonal independence of <i>JAK2</i> and <i>CALR</i> or <i>MPL</i> mutations in comutated myeloproliferative neoplasms demonstrated by single cell DNA sequencing

by Ella R. Thompson, Tamia Nguyen, Yamuna Kankanige, Paul Yeh, Michael Ingbritsen, Michelle McBean, Timothy Semple, Gisela Mir Arnau, Kate Burbury, Nora Lee, Amit Khot, David Westerman, Piers Blombery
Published 2020-08-01

580 High dose-rate brachytherapy of localized prostate cancer converts tumors from cold to hot

by Shahneen Sandhu, Heloise Halse, Minyu Wang, Catherine Mitchell, Franco Caramia, Sue Haupt, Georgina Ryland, Piers Blombery, Ygal Haupt, Simon Keam, ThuNgoc Nguyen, Nicolas Van Kooten Losio, David Byrne, Scott Williams
Published 2020-11-01

Azacitidine with or without lenalidomide in higher risk myelodysplastic syndrome & low blast acute myeloid leukemia

by Melita Kenealy, Mark Hertzberg, Warwick Benson, Kerry Taylor, Ilona Cunningham, Will Stevenson, Devendra Hiwase, Richard Eek, Daniela Zantomio, Steve Jong, Meaghan Wall, Piers Blombery, Tracey Gerber, Marlyse Debrincat, Diana Zannino, John F. Seymour
Published 2019-04-01

Biallelic deleterious germline SH2B3 variants cause a novel syndrome of myeloproliferation and multi‐organ autoimmunity

by Piers Blombery, Vahid Pazhakh, Adriana S. Albuquerque, Jesmeen Maimaris, Lingge Tu, Brenda Briones Miranda, Florence Evans, Ella R. Thompson, Ben Carpenter, Ian Proctor, Julie A. Curtin, Jonathan Lambert, Siobhan O. Burns, Graham J. Lieschke
Published 2023-05-01

High dose-rate brachytherapy of localized prostate cancer converts tumors from cold to hot

by Simon P Keam, Heloise Halse, Thu Nguyen, Minyu Wang, Nicolas Van Kooten Losio, Catherine Mitchell, Franco Caramia, David J Byrne, Sue Haupt, Georgina Ryland, Phillip K Darcy, Piers Blombery, Ygal Haupt, Scott G Williams
Published 2020-06-01

Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations

by Richard W. Birkinshaw, Jia-nan Gong, Cindy S. Luo, Daisy Lio, Christine A. White, Mary Ann Anderson, Piers Blombery, Guillaume Lessene, Ian J. Majewski, Rachel Thijssen, Andrew W. Roberts, David C. S. Huang, Peter M. Colman, Peter E. Czabotar
Published 2019-06-01

Analysis of 3760 hematologic malignancies reveals rare transcriptomic aberrations of driver genes

by Xueqi Cao, Sandra Huber, Ata Jadid Ahari, Franziska R. Traube, Marc Seifert, Christopher C. Oakes, Polina Secheyko, Sergey Vilov, Ines F. Scheller, Nils Wagner, Vicente A. Yépez, Piers Blombery, Torsten Haferlach, Matthias Heinig, Leonhard Wachutka, Stephan Hutter, Julien Gagneur
Published 2024-05-01

Utility of clinical comprehensive genomic characterization for diagnostic categorization in patients presenting with hypocellular bone marrow failure syndromes

by Piers Blombery, Lucy Fox, Georgina L. Ryland, Ella R. Thompson, Jennifer Lickiss, Michelle McBean, Satwica Yerneni, David Hughes, Anthea Greenway, Francoise Mechinaud, Erica M. Wood, Graham J. Lieschke, Jeff Szer, Pasquale Barbaro, John Roy, Joel Wight, Elly Lynch, Melissa Martyn, Clara Gaff, David Ritchie
Published 2020-02-01

S176: FUNCTIONAL AND ANTIGEN-SPECIFIC CHARACTERIZATION OF IMMUNE CELLS AT THE SINGLE-CELL LEVEL REVEALS CONVERGENCE OF ADAPTIVE AND INNATE IMMUNITY IN IMMUNE APLASTIC ANEMIA

by Jani Huuhtanen, Sofie Lundgren, Mikko Keränen, Xingim Feng, Alina Dulau-Florea, Bhavisha Patel, Yoshitaka Zaimoku, Cassandra Kerr, Emmi Jokinen, Markus Heinonen, Hanna Rajala, Sanna Siitonen, Freja Ebeling, Georgina Ryland, Lucy Fox, Piers Blombery, Eva Hellström-Lindberg, Jaroslaw P. Maciejewski, Neal S. Young, Harri Lähdesmäki, Satu Mustjoki
Published 2023-08-01

P1117: GLOFITAMAB PLUS R-CHOP OR POLATUZUMAB VEDOTIN-R-CHP IS DELIVERABLE AND YIELDS HIGH OVERALL RESPONSE IN PATIENTS <=65 YEARS OF AGE WITH HIGH-RISK DLBCL OR HGBL: INTERIM ANALY...

by Adrian Minson, Emma Verner, Pratyush Giri, Shu Min Wong, Sumita Ratnasingam, Jason Butler, Wojciech Janowski, Matthew Ku, Chan Cheah, Mark Hertzberg, Kirsten Herbert, Nada Hamad, Costas Yannakou, Paul Neeson, Javad Saghebi, Piers Blombery, Molly Robertson, Lei Shong Lau, Jing Xie, John Seymour, Michael Dickinson
Published 2023-08-01