A high-throughput screen against pantothenate synthetase (PanC) identifies 3-biphenyl-4-cyanopyrrole-2-carboxylic acids as a new class of inhibitor with activity against Mycobacter...

by Anuradha Kumar, Allen Casey, Joshua Odingo, Edward A Kesicki, Garth Abrahams, Michal Vieth, Thierry Masquelin, Valerie Mizrahi, Philip A Hipskind, David R Sherman, Tanya Parish
Published 2013-01-01

In Vitro Evaluation of Novel Nitazoxanide Derivatives against Mycobacterium tuberculosis

by Joshua Odingo, Mai A. Bailey, Megan Files, Julie V. Early, Torey Alling, Devon Dennison, Julie Bowman, Suryakanta Dalai, Naresh Kumar, Jeffrey Cramer, Thierry Masquelin, Philip A. Hipskind, Tanya Parish
Published 2017-09-01

Synthesis and Evaluation of the 2-Aminothiazoles as Anti-Tubercular Agents.

by Edward A Kesicki, Mai A Bailey, Yulia Ovechkina, Julie V Early, Torey Alling, Julie Bowman, Edison S Zuniga, Suryakanta Dalai, Naresh Kumar, Thierry Masquelin, Philip A Hipskind, Joshua O Odingo, Tanya Parish
Published 2016-01-01

Novel Trifluoromethyl Pyrimidinone Compounds With Activity Against Mycobacterium tuberculosis

by Erik Hembre, Julie V. Early, Joshua Odingo, Catherine Shelton, Olena Anoshchenko, Junitta Guzman, Lindsay Flint, Devon Dennison, Matthew B. McNeil, Aaron Korkegian, Yulia Ovechkina, Yulia Ovechkina, Paul Ornstein, Thierry Masquelin, Philip A. Hipskind, Tanya Parish, Tanya Parish
Published 2021-04-01

Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Mycobacterium tuberculosis Growth

by Peter C. Ray, Margaret Huggett, Penelope A. Turner, Malcolm Taylor, Laura A. T. Cleghorn, Julie Early, Anuradha Kumar, Shilah A. Bonnett, Lindsay Flint, Douglas Joerss, James Johnson, Aaron Korkegian, Steven Mullen, Abraham L. Moure, Susan H. Davis, Dinakaran Murugesan, Michael Mathieson, Nicola Caldwell, Curtis A. Engelhart, Dirk Schnappinger, Ola Epemolu, Fabio Zuccotto, Jennifer Riley, Paul Scullion, Laste Stojanovski, Lisa Massoudi, Gregory T. Robertson, Anne J. Lenaerts, Gail Freiberg, Dale J. Kempf, Thierry Masquelin, Philip A. Hipskind, Joshua Odingo, Kevin D. Read, Simon R. Green, Paul G. Wyatt, Tanya Parish
Published 2021-01-01