A global view of the aspiring physician-scientist

by Christopher S Williams, W Kimryn Rathmell, John M Carethers, Diane M Harper, YM Dennis Lo, Peter J Ratcliffe, Mone Zaidi
Published 2022-09-01

Gene panel sequencing improves the diagnostic work-up of patients with idiopathic erythrocytosis and identifies new mutations

by Carme Camps, Nayia Petousi, Celeste Bento, Holger Cario, Richard R. Copley, Mary Frances McMullin, Richard van Wijk, Peter J. Ratcliffe, Peter A. Robbins, Jenny C. Taylor
Published 2016-11-01

Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway.

by Steffen Grampp, Virginia Schmid, Rafik Salama, Victoria Lauer, Franziska Kranz, James L Platt, James Smythies, Hani Choudhry, Margarete Goppelt-Struebe, Peter J Ratcliffe, David R Mole, Johannes Schödel
Published 2017-07-01

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates

by Matthew E Cockman, Kerstin Lippl, Ya-Min Tian, Hamish B Pegg, William D Figg Jnr, Martine I Abboud, Raphael Heilig, Roman Fischer, Johanna Myllyharju, Christopher J Schofield, Peter J Ratcliffe
Published 2019-09-01

Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans.

by Tammie Bishop, Kah Weng Lau, Andrew C R Epstein, Stuart K Kim, Min Jiang, Delia O'Rourke, Christopher W Pugh, Jonathan M Gleadle, Martin S Taylor, Jonathan Hodgkin, Peter J Ratcliffe
Published 2004-10-01

Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α).

by Armin Thalhammer, Zuzana Bencokova, Rachel Poole, Christoph Loenarz, Julie Adam, Linda O'Flaherty, Johannes Schödel, David Mole, Konstantinos Giaslakiotis, Christopher J Schofield, Ester M Hammond, Peter J Ratcliffe, Patrick J Pollard
Published 2011-01-01

Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer

by Steffen Grampp, James L. Platt, Victoria Lauer, Rafik Salama, Franziska Kranz, Viviana K. Neumann, Sven Wach, Christine Stöhr, Arndt Hartmann, Kai-Uwe Eckardt, Peter J. Ratcliffe, David R. Mole, Johannes Schödel
Published 2016-10-01

Abnormal whole-body energy metabolism in iron-deficient humans despite preserved skeletal muscle oxidative phosphorylation

by Matthew C. Frise, David A. Holdsworth, Andrew W. Johnson, Yu Jin Chung, M. Kate Curtis, Pete J. Cox, Kieran Clarke, Damian J. Tyler, David J. Roberts, Peter J. Ratcliffe, Keith L. Dorrington, Peter A. Robbins
Published 2022-01-01

Publisher Correction: Abnormal whole-body energy metabolism in iron-deficient humans despite preserved skeletal muscle oxidative phosphorylation

by Matthew C. Frise, David A. Holdsworth, Andrew W. Johnson, Yu Jin Chung, M. Kate Curtis, Pete J. Cox, Kieran Clarke, Damian J. Tyler, David J. Roberts, Peter J. Ratcliffe, Keith L. Dorrington, Peter A. Robbins
Published 2022-03-01

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases

by Rasheduzzaman Chowdhury, Ivanhoe K. H. Leung, Ya-Min Tian, Martine I. Abboud, Wei Ge, Carmen Domene, François-Xavier Cantrelle, Isabelle Landrieu, Adam P. Hardy, Christopher W. Pugh, Peter J. Ratcliffe, Timothy D. W. Claridge, Christopher J. Schofield
Published 2016-08-01

Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology.

by Thomas G Smith, Jerome T Brooks, George M Balanos, Terence R Lappin, D Mark Layton, Dawn L Leedham, Chun Liu, Patrick H Maxwell, Mary F McMullin, Christopher J McNamara, Melanie J Percy, Christopher W Pugh, Peter J Ratcliffe, Nick P Talbot, Marilyn Treacy, Peter A Robbins
Published 2006-07-01

Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain.

by Mun Chiang Chan, Onur Atasoylu, Emma Hodson, Anthony Tumber, Ivanhoe K H Leung, Rasheduzzaman Chowdhury, Verónica Gómez-Pérez, Marina Demetriades, Anna M Rydzik, James Holt-Martyn, Ya-Min Tian, Tammie Bishop, Timothy D W Claridge, Akane Kawamura, Christopher W Pugh, Peter J Ratcliffe, Christopher J Schofield
Published 2015-01-01

A Role for Cytosolic Fumarate Hydratase in Urea Cycle Metabolism and Renal Neoplasia

by Julie Adam, Ming Yang, Christina Bauerschmidt, Mitsuhiro Kitagawa, Linda O’Flaherty, Pratheesh Maheswaran, Gizem Özkan, Natasha Sahgal, Dilair Baban, Keiko Kato, Kaori Saito, Keiko Iino, Kaori Igarashi, Michael Stratford, Christopher Pugh, Daniel A. Tennant, Christian Ludwig, Benjamin Davies, Peter J. Ratcliffe, Mona El-Bahrawy, Houman Ashrafian, Tomoyoshi Soga, Patrick J. Pollard
Published 2013-05-01

Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells

by Peter A.C. Wing, Thomas P. Keeley, Xiaodong Zhuang, Jeffrey Y. Lee, Maria Prange-Barczynska, Senko Tsukuda, Sophie B. Morgan, Adam C. Harding, Isobel L.A. Argles, Samvid Kurlekar, Marko Noerenberg, Craig P. Thompson, Kuan-Ying A. Huang, Peter Balfe, Koichi Watashi, Alfredo Castello, Timothy S.C. Hinks, William James, Peter J. Ratcliffe, Ilan Davis, Emma J. Hodson, Tammie Bishop, Jane A. McKeating
Published 2021-04-01

Erythrocytosis associated with a novel missense mutation in the BPGM gene

by Nayia Petousi, Richard R. Copley, Terence R.J. Lappin, Sally E. Haggan, Celeste M. Bento, Holger Cario, Melanie J. Percy, The WGS Consortium, Peter J. Ratcliffe, Peter A. Robbins, Mary Frances McMullin, Peter Donnelly, John Bell, David Bentley, Gil McVean, Peter Ratcliffe, Jenny Taylor, Andrew Wilkie, Peter Donelly, John Broxholme, David Buck, Jean-Baptiste Cazier, Richard Cornall, Lorna Gregory, Julian Knight, Gerton Lunter, Gil McVean, Ian Tomlinson, Andrew Wilkie, David Buck, Christopher Allan, Moustafa Attar, Angie Green, Lorna Gregory, Sean Humphray, Zoya Kingsbury, Sarah Lamble, Lorne Lonie, Alistair Pagnamenta, Paolo Piazza, Guadelupe Polanco, Amy Trebes, Gil McVean, Peter Donnelly, Jean-Baptiste Cazier, John Broxholme, Richard Copley, Simon Fiddy, Russell Grocock, Edouard Hatton, Chris Holmes, Linda Hughes, Peter Humburg, Alexander Kanapin, Stefano Lise, Gerton Lunter, Hilary Martin, Lisa Murray, Davis McCarthy, Andy Rimmer, Natasha Sahgal, Ben Wright, Chris Yau
Published 2014-10-01

Pathways for oxygen regulation and homeostasis: the 2016 Albert Lasker Basic Medical Research Award

by Kaelin, W, Ratcliffe, P, Semenza, G
Published 2016