De novo peptide design and experimental validation of histone methyltransferase inhibitors.

by James Smadbeck, Meghan B Peterson, Barry M Zee, Shivani Garapaty, Aashna Mago, Christina Lee, Athanassios Giannis, Patrick Trojer, Benjamin A Garcia, Christodoulos A Floudas
Published 2014-01-01

De novo peptide design and experimental validation of histone methyltransferase inhibitors.

by James Smadbeck, Meghan B Peterson, Barry M Zee, Shivani Garapaty, Aashna Mago, Christina Lee, Athanassios Giannis, Patrick Trojer, Benjamin A Garcia, Christodoulos A Floudas
Published 2014-01-01

765 The first-in-class small molecule TREX1 inhibitor CPI-381 demonstrates type I IFN induction and sensitization of tumors to immune checkpoint blockade

by Jonathan Wilson, Lei Cui, Costa Salojin, Anna Gardberg, Valerie Vivat, Jeffrey Lauer, Nico Cantone, Jacob Stuckey, Florence Poy, Ingrid Almeciga, Richard Cummings, Julian Levell, Jennifer Rocnik, Patrick Trojer
Published 2021-11-01

An Alternative Approach to ChIP-Seq Normalization Enables Detection of Genome-Wide Changes in Histone H3 Lysine 27 Trimethylation upon EZH2 Inhibition.

by Brian Egan, Chih-Chi Yuan, Madeleine Lisa Craske, Paul Labhart, Gulfem D Guler, David Arnott, Tobias M Maile, Jennifer Busby, Chisato Henry, Theresa K Kelly, Charles A Tindell, Suchit Jhunjhunwala, Feng Zhao, Charlie Hatton, Barbara M Bryant, Marie Classon, Patrick Trojer
Published 2016-01-01