Controlled Human Malaria Infection in Semi-Immune Kenyan Adults (CHMI-SIKA): a study protocol to investigate in vivo Plasmodium falciparum malaria parasite growth in the context of...

by Melissa C. Kapulu, Patricia Njuguna, Mainga M. Hamaluba, CHMI-SIKA Study Team
Published 2019-11-01

A seven-year study on the effect of the pre-erythrocytic malaria vaccine candidate RTS,S/AS01E on blood stage immunity in young Kenyan children [version 1; peer review: 1 approved,...

by Francis M. Ndungu, Jedida Mwacharo, Juliana Wambua, Patricia Njuguna, Kevin Marsh, Chris Drakeley, Philip Bejon
Published 2019-03-01

Ethical considerations in Controlled Human Malaria Infection studies in low resource settings: Experiences and perceptions of study participants in a malaria Challenge study in Ken...

by Maureen Njue, Patricia Njuguna, Melissa C. Kapulu, Gladys Sanga, Philip Bejon, Vicki Marsh, Sassy Molyneux, Dorcas Kamuya
Published 2018-10-01

Ethical considerations in Controlled Human Malaria Infection studies in low resource settings: Experiences and perceptions of study participants in a malaria Challenge study in Ken...

by Maureen Njue, Patricia Njuguna, Melissa C. Kapulu, Gladys Sanga, Philip Bejon, Vicki Marsh, Sassy Molyneux, Dorcas Kamuya
Published 2018-04-01

Pragmatism in practice: lessons learned during screening and enrollment for a randomised controlled trial in rural northern Ethiopia

by Meseret Molla, Henok Negussie, Moses Ngari, Esther Kivaya, Patricia Njuguna, Fikre Enqueselassie, James A. Berkley, Gail Davey
Published 2018-03-01

A Phase 2a Randomized Study to Evaluate the Safety and Immunogenicity of the 1790GAHB Generalized Modules for Membrane Antigen Vaccine against Shigella sonnei Administered Intramus...

by Christina W. Obiero, Augustin G. W. Ndiaye, Antonella Silvia Sciré, Bonface M. Kaunyangi, Elisa Marchetti, Ann M. Gone, Lena Dorothee Schütte, Daniele Riccucci, Joachim Auerbach, Allan Saul, Laura B. Martin, Philip Bejon, Patricia Njuguna, Patricia Njuguna, Audino Podda
Published 2017-12-01

Avidity of anti-circumsporozoite antibodies following vaccination with RTS,S/AS01E in young children.

by Ally Olotu, Frederic Clement, Erik Jongert, Johan Vekemans, Patricia Njuguna, Francis M Ndungu, Kevin Marsh, Geert Leroux-Roels, Philip Bejon
Published 2014-01-01

Undertaking Community Engagement for a Controlled Human Malaria Infection Study in Kenya: Approaches and Lessons Learnt

by Noni Mumba, Patricia Njuguna, Patricia Njuguna, Primus Chi, Vicki Marsh, Vicki Marsh, Esther Awuor, Mainga Hamaluba, Mainga Hamaluba, Cynthia Mauncho, Salim Mwalukore, Johnson Masha, Mary Mwangoma, Betty Kalama, Hassan Alphan, Juliana Wambua, Philip Bejon, Philip Bejon, Dorcas Kamuya, Dorcas Kamuya, Melissa C. Kapulu, Melissa C. Kapulu
Published 2022-04-01

Controlled human malaria infection (CHMI) outcomes in Kenyan adults is associated with prior history of malaria exposure and anti-schizont antibody response

by Melissa C. Kapulu, Domtila Kimani, Patricia Njuguna, Mainga Hamaluba, Edward Otieno, Rinter Kimathi, James Tuju, B. Kim Lee Sim, CHMI-SIKA Study Team
Published 2022-01-01

Risk of pneumococcal bacteremia in Kenyan children with glucose-6-phosphate dehydrogenase deficiency

by James J. Gilchrist, Sophie Uyoga, Matti Pirinen, Anna Rautanen, Salim Mwarumba, Patricia Njuguna, Neema Mturi, The Kenyan Bacteraemia Study Group, Adrian V. S. Hill, J. Anthony G. Scott, Thomas N. Williams
Published 2020-06-01

Clinical laboratory reference values amongst children aged 4 weeks to 17 months in Kilifi, Kenya: A cross sectional observational study.

by Jesse Gitaka, Caroline Ogwang, Moses Ngari, Pauline Akoo, Ally Olotu, Christine Kerubo, Greg Fegan, Patricia Njuguna, Godfrey Nyakaya, Tuda Otieno, Gabriel Mwambingu, Ken Awuondo, Brett Lowe, Roma Chilengi, James A Berkley
Published 2017-01-01

Children’s Oxygen Administration Strategies Trial (COAST):  A randomised controlled trial of high flow versus oxygen versus control in African children with severe pneumonia [versi...

by Kathryn Maitland, Sarah Kiguli, Robert O. Opoka, Peter Olupot-Olupot, Charles Engoru, Patricia Njuguna, Victor Bandika, Ayub Mpoya, Andrew Bush, Thomas N. Williams, Richard Grieve, Zia Sadique, John Fraser, David Harrison, Kathy Rowan
Published 2018-01-01

Safety and PCR monitoring in 161 semi-immune Kenyan adults following controlled human malaria infection

by Melissa C. Kapulu, Patricia Njuguna, Mainga Hamaluba, Domtila Kimani, Joyce M. Ngoi, Janet Musembi, Omar Ngoto, Edward Otieno, Peter F. Billingsley, the Controlled Human Malaria Infection in Semi-Immune Kenyan Adults (CHMI-SIKA) Study Team
Published 2021-09-01

Cost-effectiveness and social outcomes of a community-based treatment for podoconiosis lymphoedema in the East Gojjam zone, Ethiopia.

by Natalia Hounsome, Meseret Molla Kassahun, Moses Ngari, James A Berkley, Esther Kivaya, Patricia Njuguna, Greg Fegan, Abreham Tamiru, Abebe Kelemework, Tsige Amberbir, Annabelle Clarke, Trudie Lang, Melanie J Newport, Andy McKay, Fikre Enquoselassie, Gail Davey
Published 2019-10-01

Complement-mediated serum bactericidal activity of antibodies elicited by the Shigella sonnei GMMA vaccine in adults from a shigellosis-endemic country: Exploratory analysis of a P...

by Melissa C. Kapulu, Melissa C. Kapulu, Usman Nakakana, Antonella S. Sciré, Eleanna Sarakinou, Valentino Conti, Omar Rossi, Alessandra Acquaviva, Francesca Necchi, Christina W. Obiero, Laura B. Martin, Philip Bejon, Philip Bejon, Patricia Njuguna, Francesca Micoli, Audino Podda
Published 2022-09-01

Excess child mortality after discharge from hospital in Kilifi, Kenya: a retrospective cohort analysis

by Jennifer C Moïsi, Hellen Gatakaa, James A Berkley, Kathryn Maitland, Neema Mturi, Charles R Newton, Patricia Njuguna, James Nokes, John Ojal, Evasius Bauni, Benjamin Tsofa, Norbert Peshu, Kevin Marsh, Thomas N Williams, J Anthony G Scott

Phagocytosis of Plasmodium falciparum ring-stage parasites predicts protection against malaria

by Fauzia K. Musasia, Irene N. Nkumama, Roland Frank, Victor Kipkemboi, Martin Schneider, Kennedy Mwai, Dennis O. Odera, Micha Rosenkranz, Kristin Fürle, Domitila Kimani, James Tuju, Patricia Njuguna, Mainga Hamaluba, Melissa C. Kapulu, Hedda Wardemann, CHMI-SIKA Study Team, Faith H. A. Osier
Published 2022-07-01

Age, Spatial, and Temporal Variations in Hospital Admissions with Malaria in Kilifi County, Kenya: A 25-Year Longitudinal Observational Study.

by Polycarp Mogeni, Thomas N Williams, Gregory Fegan, Christopher Nyundo, Evasius Bauni, Kennedy Mwai, Irene Omedo, Patricia Njuguna, Charles R Newton, Faith Osier, James A Berkley, Laura L Hammitt, Brett Lowe, Gabriel Mwambingu, Ken Awuondo, Neema Mturi, Norbert Peshu, Robert W Snow, Abdisalan Noor, Kevin Marsh, Philip Bejon
Published 2016-06-01

Observational study: 27 years of severe malaria surveillance in Kilifi, Kenya

by Patricia Njuguna, Kathryn Maitland, Amek Nyaguara, Daniel Mwanga, Polycarp Mogeni, Neema Mturi, Shebe Mohammed, Gabriel Mwambingu, Caroline Ngetsa, Kenedy Awuondo, Brett Lowe, Ifedayo Adetifa, J. Anthony G. Scott, Thomas N. Williams, Sarah Atkinson, Faith Osier, Robert W. Snow, Kevin Marsh, Benjamin Tsofa, Norbert Peshu, Mainga Hamaluba, James A. Berkley, Charles R. J. Newton, John Fondo, Anisa Omar, Philip Bejon
Published 2019-07-01

Risk of nontyphoidal Salmonella bacteraemia in African children is modified by STAT4

by James J. Gilchrist, Anna Rautanen, Benjamin P. Fairfax, Tara C. Mills, Vivek Naranbhai, Holly Trochet, Matti Pirinen, Esther Muthumbi, Salim Mwarumba, Patricia Njuguna, Neema Mturi, Chisomo L. Msefula, Esther N. Gondwe, Jenny M. MacLennan, Stephen J. Chapman, Malcolm E. Molyneux, Julian C. Knight, Chris C. A. Spencer, Thomas N. Williams, Calman A. MacLennan, J. Anthony G. Scott, Adrian V. S. Hill
Published 2018-03-01