The matrix proteins aggrecan and fibulin-1 play a key role in determining aortic stiffness.

by Yasmin, Maskari, Raya Al, McEniery, Carmel M, Cleary, Sarah E, Li, Ye, Siew, Keith, Figg, Nichola L, Khir, Ashraf W, Cockcroft, John R, Wilkinson, Ian B, O'Shaughnessy, Kevin M
Published 2018

A missense TGFB2 variant p.(Arg320Cys) causes a paradoxical and striking increase in aortic TGFB1/2 expression.

by Al Maskari, Raya, Yasmin, Cleary, S, Figg, Nikki, Mehta, Sarju, Rassl, Doris, Wilkinson, Ian, O'Shaughnessy, Kevin M
Published 2016

β1-Adrenoreceptor Polymorphisms and Blood Pressure: 49S Variant Increases Plasma Renin But Not Blood Pressure in Hypertensive Patients.

by Sandilands, Alastair J, O'Shaughnessy, Kevin M
Published 2019

Modified HEK cells simulate DCT cells in their sensitivity and response to changes in extracellular K.

by Murthy, Meena, O'Shaughnessy, Kevin M
Published 2020

Modified HEK cells simulate DCT cells in their sensitivity and response to changes in extracellular K.

by Murthy, Meena, O'Shaughnessy, Kevin M
Published 2019

Nonadherence to antihypertensive medications amongst patients with uncontrolled hypertension: A retrospective study.

by Kulkarni, Spoorthy, Rao, Raunak, Goodman, James Delman Harry, Connolly, Kathleen, O'Shaughnessy, Kevin M
Published 2021

Targeted disruption of the Kcnj5 gene in the female mouse lowers aldosterone levels.

by Hardege, Iris, Long, Lu, Al Maskari, Raya, Figg, Nicola, O'Shaughnessy, Kevin M
Published 2018

WNK signalling pathways in blood pressure regulation.

by Murthy, Meena, Kurz, Thimo, O'Shaughnessy, Kevin M
Published 2017

Critical role of the SPAK protein kinase CCT domain in controlling blood pressure.

by Zhang, Jinwei, Siew, Keith, Macartney, Thomas, O'Shaughnessy, Kevin M, Alessi, Dario R
Published 2015

Characterisation of the Cullin‐3 mutation that causes a severe form of familial hypertension and hyperkalaemia

by Schumacher, Frances-Rose, Siew, Keith, Zhang, Jinwei, Johnson, Clare, Wood, Nicola, Cleary, Sarah E., Al Maskari, Raya S., Ferryman, James T., Hardege, Iris, Yasmin, Figg, Nichola L., Enchev, Radoslav, Knebel, Axel, O'Shaughnessy, Kevin M., Kurz, Thimo
Published 2015

Detection of mutations in KLHL3 and CUL3 in families with FHHt (familial hyperkalaemic hypertension or Gordon's syndrome).

by Glover, Mark, Ware, James S, Henry, Amanda, Wolley, Martin, Walsh, Roddy, Wain, Louise V, Xu, Shengxin, Van't Hoff, William G, Tobin, Martin D, Hall, Ian P, Cook, Stuart, Gordon, Richard D, Stowasser, Michael, O'Shaughnessy, Kevin M
Published 2014

ROMK expression remains unaltered in a mouse model of familial hyperkalemic hypertension caused by the CUL3Δ403-459 mutation.

by Murthy, Meena, Kurz, Thimo, O'Shaughnessy, Kevin M
Published 2016

Phenotypic and pharmacogenetic evaluation of patients with thiazide-induced hyponatremia.

by Ware, James S, Wain, Louise V, Channavajjhala, Sarath K, Jackson, Victoria E, Edwards, Elizabeth, Lu, Run, Siew, Keith, Jia, Wenjing, Shrine, Nick, Kinnear, Sue, Jalland, Mahli, Henry, Amanda P, Clayton, Jenny, O'Shaughnessy, Kevin M, Tobin, Martin D, Schuster, Victor L, Cook, Stuart, Hall, Ian P, Glover, Mark
Published 2019