Super Potent Bispecific Llama VHH Antibodies Neutralize HIV via a Combination of gp41 and gp120 Epitopes

by Nika M. Strokappe, Miriam Hock, Lucy Rutten, Laura E. Mccoy, Jaap W. Back, Christophe Caillat, Matthias Haffke, Robin A. Weiss, Winfried Weissenhorn, Theo Verrips
Published 2019-06-01

A Universal Approach to Optimize the Folding and Stability of Prefusion-Closed HIV-1 Envelope Trimers

by Lucy Rutten, Yen-Ting Lai, Sven Blokland, Daphne Truan, Ilona J.M. Bisschop, Nika M. Strokappe, Annemart Koornneef, Danielle van Manen, Gwo-Yu Chuang, S. Katie Farney, Hanneke Schuitemaker, Peter D. Kwong, Johannes P.M. Langedijk
Published 2018-04-01

Molecular evolution of broadly neutralizing Llama antibodies to the CD4-binding site of HIV-1.

by Laura E McCoy, Lucy Rutten, Dan Frampton, Ian Anderson, Luke Granger, Rachael Bashford-Rogers, Gillian Dekkers, Nika M Strokappe, Michael S Seaman, Willie Koh, Vanina Grippo, Alexander Kliche, Theo Verrips, Paul Kellam, Ariberto Fassati, Robin A Weiss
Published 2014-12-01

Directing HIV-1 for degradation by non-target cells, using bi-specific single-chain llama antibodies

by Jord C. Stam, Steven de Maat, Dorien de Jong, Mathia Arens, Fenna van Lint, Lavina Gharu, Mark H. van Roosmalen, Rob C. Roovers, Nika M. Strokappe, Ralf Wagner, Alexander Kliche, Hans J. de Haard, Paul M. van Bergen en Henegouwen, Monique Nijhuis, C. Theo Verrips
Published 2022-08-01

CoPoP liposomes displaying stabilized clade C HIV-1 Env elicit tier 2 multiclade neutralization in rabbits

by Annemart Koornneef, Kanika Vanshylla, Gijs Hardenberg, Lucy Rutten, Nika M. Strokappe, Jeroen Tolboom, Jessica Vreugdenhil, Karin Feddes-de Boer, Aditya Perkasa, Sven Blokland, Judith A. Burger, Wei-Chiao Huang, Jonathan F. Lovell, Danielle van Manen, Rogier W. Sanders, Roland C. Zahn, Hanneke Schuitemaker, Johannes P. M. Langedijk, Frank Wegmann
Published 2024-04-01

A gp41 MPER-specific llama VHH requires a hydrophobic CDR3 for neutralization but not for antigen recognition.

by David Lutje Hulsik, Ying-ying Liu, Nika M Strokappe, Simone Battella, Mohamed El Khattabi, Laura E McCoy, Charles Sabin, Andreas Hinz, Miriam Hock, Pauline Macheboeuf, Alexandre M J J Bonvin, Johannes P M Langedijk, David Davis, Anna Forsman Quigley, Marlén M I Aasa-Chapman, Michael S Seaman, Alejandra Ramos, Pascal Poignard, Adrien Favier, Jean-Pierre Simorre, Robin A Weiss, C Theo Verrips, Winfried Weissenhorn, Lucy Rutten
Published 2013-03-01

Neutralization Properties of Simian Immunodeficiency Viruses Infecting Chimpanzees and Gorillas

by Hannah J. Barbian, Julie M. Decker, Frederic Bibollet-Ruche, Rachel P. Galimidi, Anthony P. West, Gerald H. Learn, Nicholas F. Parrish, Shilpa S. Iyer, Yingying Li, Craig S. Pace, Ruijiang Song, Yaoxing Huang, Thomas N. Denny, Hugo Mouquet, Loic Martin, Priyamvada Acharya, Baoshan Zhang, Peter D. Kwong, John R. Mascola, C. Theo Verrips, Nika M. Strokappe, Lucy Rutten, Laura E. McCoy, Robin A. Weiss, Corrine S. Brown, Raven Jackson, Guido Silvestri, Mark Connors, Dennis R. Burton, George M. Shaw, Michel C. Nussenzweig, Pamela J. Bjorkman, David D. Ho, Michael Farzan, Beatrice H. Hahn
Published 2015-05-01

Potent and Broad Neutralization of HIV-1 by a Llama Antibody Elicited by Immunization

by McCoy, Laura E., Quigley, Anna Forsman, Strokappe, Nika M., Bulmer-Thomas, Bianca, Mortier, Daniella, Rutten, Lucy, Chander, Nikita, Edwards, Carolyn J., Ketteler, Robin, Verrips, Theo, Weiss, Robin A., Seaman, Michael S., Davis, David
Published 2013

A gp41 MPER-specific Llama VHH Requires a Hydrophobic CDR3 for Neutralization but not for Antigen Recognition

by Lutje Hulsik, David, Liu, Ying-ying, Strokappe, Nika M., Battella, Simone, El Khattabi, Mohamed, McCoy, Laura E., Sabin, Charles, Hinz, Andreas, Hock, Miriam, Macheboeuf, Pauline, Bonvin, Alexandre M. J. J., Langedijk, Johannes P. M., Davis, David, Forsman Quigley, Anna, Aasa-Chapman, Marlén M. I., Seaman, Michael S., Ramos, Alejandra, Poignard, Pascal, Favier, Adrien, Simorre, Jean-Pierre, Weiss, Robin A., Verrips, C. Theo, Weissenhorn, Winfried, Rutten, Lucy
Published 2013