A phase 2 double-blind placebo-controlled 24-week treatment clinical study of the p38 alpha kinase inhibitor neflamapimod in mild Alzheimer’s disease

by Niels D. Prins, John E. Harrison, Hui-May Chu, Kelly Blackburn, John J. Alam, Philip Scheltens, for the REVERSE-SD Study Investigators
Published 2021-05-01

Microbleeds are associated with depressive symptoms in Alzheimer's disease

by Anna E. Leeuwis, Niels D. Prins, Astrid M. Hooghiemstra, Marije R. Benedictus, Philip Scheltens, Frederik Barkhof, Wiesje M. van derFlier
Published 2018-01-01

Experiences of and recommendations on clinical trial design in Alzheimer’s disease from the participant’s point of view: a mixed-methods study in two clinical trial centers in the...

by Lois Ottenhoff, Everard G. B. Vijverberg, Leonie N. C. Visser, Merike Verijp, Niels D. Prins, Wiesje M. Van der Flier, Sietske A. M. Sikkes
Published 2023-04-01

Methylphenidate and galantamine in patients with vascular cognitive impairment–the proof-of-principle study STREAM-VCI

by Jolien F. Leijenaar, Geert Jan Groeneveld, Erica S. Klaassen, Anna E. Leeuwis, Philip Scheltens, Henry C. Weinstein, Joop M. A. van Gerven, Frederik Barkhof, Wiesje M. van der Flier, Niels D. Prins
Published 2020-01-01

Safety, tolerability and efficacy of the glutaminyl cyclase inhibitor PQ912 in Alzheimer’s disease: results of a randomized, double-blind, placebo-controlled phase 2a study

by Philip Scheltens, Merja Hallikainen, Timo Grimmer, Thomas Duning, Alida A Gouw, Charlotte E Teunissen, Alle Meije Wink, Paul Maruff, John Harrison, Caroline M van Baal, Suzanne Bruins, Inge Lues, Niels D Prins
Published 2018-10-01

Small vessel disease lesion type and brain atrophy: The role of co‐occurring amyloid

by Rutger Heinen, Onno N. Groeneveld, Frederik Barkhof, Jeroen deBresser, Lieza G. Exalto, Hugo J. Kuijf, Niels D. Prins, Philip Scheltens, Wiesje M. vander Flier, Geert Jan Biessels, the TRACE‐VCI study group
Published 2020-01-01

Vascular Cognitive Impairment and cognitive decline; a longitudinal study comparing different types of vascular brain injury - The TRACE-VCI study

by Jooske MF Boomsma, Lieza G Exalto, Frederik Barkhof, Anna E Leeuwis, Niels D Prins, Philip Scheltens, Charlotte E Teunissen, Henry C Weinstein, Geert Jan Biessels, Wiesje M van der Flier, On-behalf-of-the-TRACE-VCI-study-group
Published 2022-01-01

Decreased integrity of the monoaminergic tract is associated with a positive response to MPH in patients with vascular cognitive impairment - proof of principle study STREAM-VCI

by Jolene F Leijenaar, Silvia Ingala, Carole H Sudre, Henk-Jan MM Mutsaerts, Anna E. Leeuwis, Wiesje M van der Flier, Philip Scheltens, Henry C Weinstein, Frederik Barkhof, Joop van Gerven, Geert Jan Groeneveld, Niels D Prins
Published 2022-01-01

Dutch Brain Research Registry for study participant recruitment: Design and first results

by Marissa D. Zwan, Wiesje M. van derFlier, Solange Cleutjens, Tamara C Schouten, Lisa Vermunt, Roos J. Jutten, Ingrid S. vanMaurik, Sietske A.M. Sikkes, Derek Flenniken, Taylor Howell, Michael W. Weiner, Philip Scheltens, Niels D. Prins
Published 2021-01-01

Sex differences in memory clinic patients with possible vascular cognitive impairment

by Lieza G. Exalto, Jooske M. F. Boomsma, Rosha Babapour Mofrad, Frederik Barkhof, Onno N. Groeneveld, Rutger Heinen, Hugo J. Kuijf, Anna E. Leeuwis, Niels D. Prins, Geert Jan Biessels, Wiesje M. vd Flier, TRACE‐VCI study group
Published 2020-01-01

Risk of dementia in APOE ε4 carriers is mitigated by a polygenic risk score

by Jarith L. Ebenau, Sven J. van derLee, Marc Hulsman, Niccolò Tesi, Iris E. Jansen, Inge M.W. Verberk, Mardou vanLeeuwenstijn, Charlotte E. Teunissen, Frederik Barkhof, Niels D. Prins, Philip Scheltens, Henne Holstege, Bart N.M. vanBerckel, Wiesje M. van derFlier
Published 2021-01-01

Serum markers glial fibrillary acidic protein and neurofilament light for prognosis and monitoring in cognitively normal older people: a prospective memory clinic-based cohort stud...

by Inge M W Verberk, MSc, Malika B Laarhuis, MSc, Karlijn A van den Bosch, MSc, Jarith L Ebenau, MD, Mardou van Leeuwenstijn, Niels D Prins, MD, Philip Scheltens, ProfMD, Charlotte E Teunissen, ProfPhD, Wiesje M van der Flier, ProfPhD
Published 2021-02-01

Prediction of poor clinical outcome in vascular cognitive impairment: TRACE‐VCI study

by Jooske M.F. Boomsma, Lieza G. Exalto, Frederik Barkhof, Christopher L.H. Chen, Saima Hilal, Anna E. Leeuwis, Niels D. Prins, Francis N. Saridin, Philip Scheltens, Charlotte E. Teunissen, Jurre H. Verwer, Henry C. Weinstein, Wiesje M. vander Flier, Geert Jan Biessels, the TRACE‐VCI study group
Published 2020-01-01

Cerebral Blood Flow and Cognitive Functioning in a Community-Based, Multi-Ethnic Cohort: The SABRE Study

by Anna E. Leeuwis, Lorna A. Smith, Andrew Melbourne, Alun D. Hughes, Alun D. Hughes, Marcus Richards, Niels D. Prins, Magdalena Sokolska, David Atkinson, Therese Tillin, Hans R. Jäger, Nish Chaturvedi, Nish Chaturvedi, Wiesje M. van der Flier, Wiesje M. van der Flier, Frederik Barkhof, Frederik Barkhof
Published 2018-09-01

Subjective Cognitive Impairment Cohort (SCIENCe): study design and first results

by Rosalinde E. R. Slot, Sander C. J. Verfaillie, Jozefien M. Overbeek, Tessa Timmers, Linda M. P. Wesselman, Charlotte E. Teunissen, Annemiek Dols, Femke H. Bouwman, Niels D. Prins, Frederik Barkhof, Adriaan A. Lammertsma, Bart N. M. Van Berckel, Philip Scheltens, Sietske A. M. Sikkes, Wiesje M. Van der Flier
Published 2018-08-01

Dietary Patterns Are Related to Clinical Characteristics in Memory Clinic Patients with Subjective Cognitive Decline: The SCIENCe Project

by Linda M. P. Wesselman, Astrid S. Doorduijn, Francisca A. de Leeuw, Sander C. J. Verfaillie, Mardou van Leeuwenstijn-Koopman, Rosalinde E. R. Slot, Maartje I. Kester, Niels D. Prins, Ondine van de Rest, Marian A. E. de van der Schueren, Philip Scheltens, Sietske A. M. Sikkes, Wiesje M. van der Flier
Published 2019-05-01

Personalized risk for clinical progression in cognitively normal subjects—the ABIDE project

by Ingrid S. van Maurik, Rosalinde E. R. Slot, Sander C. J. Verfaillie, Marissa D. Zwan, Femke H. Bouwman, Niels D. Prins, Charlotte E. Teunissen, Philip Scheltens, Frederik Barkhof, Mike P. Wattjes, Jose Luis Molinuevo, Lorena Rami, Steffen Wolfsgruber, Oliver Peters, Frank Jessen, Johannes Berkhof, Wiesje M. van der Flier, for the Alzheimer’s Disease Neuroimaging Initiative
Published 2019-04-01

Changes in Brain-Health Related Modifiable Risk Factors in Older Adults After One Year of COVID-19-Restrictions

by Lisa Waterink, Els D. Bakker, Leonie N. C. Visser, Leonie N. C. Visser, Francesca Mangialasche, Miia Kivipelto, Miia Kivipelto, Miia Kivipelto, Miia Kivipelto, Kay Deckers, Sebastian Köhler, Sietske A. M. Sikkes, Sietske A. M. Sikkes, Niels D. Prins, Philip Scheltens, Philip Scheltens, Wiesje M. van der Flier, Wiesje M. van der Flier, Marissa D. Zwan
Published 2022-06-01

Amyloid-β Load Is Related to Worries, but Not to Severity of Cognitive Complaints in Individuals With Subjective Cognitive Decline: The SCIENCe Project

by Sander C. J. Verfaillie, Sander C. J. Verfaillie, Sander C. J. Verfaillie, Tessa Timmers, Tessa Timmers, Tessa Timmers, Rosalinde E. R. Slot, Rosalinde E. R. Slot, Chris W. J. van der Weijden, Chris W. J. van der Weijden, Linda M. P. Wesselman, Linda M. P. Wesselman, Niels D. Prins, Niels D. Prins, Sietske A. M. Sikkes, Sietske A. M. Sikkes, Sietske A. M. Sikkes, Maqsood Yaqub, Maqsood Yaqub, Annemiek Dols, Annemiek Dols, Annemiek Dols, Adriaan A. Lammertsma, Adriaan A. Lammertsma, Philip Scheltens, Philip Scheltens, Rik Ossenkoppele, Rik Ossenkoppele, Rik Ossenkoppele, Bart N. M. van Berckel, Bart N. M. van Berckel, Wiesje M. van der Flier, Wiesje M. van der Flier, Wiesje M. van der Flier
Published 2019-01-01

Prescreening for European Prevention of Alzheimer Dementia (EPAD) trial-ready cohort: impact of AD risk factors and recruitment settings

by Lisa Vermunt, Graciela Muniz-Terrera, Lea ter Meulen, Colin Veal, Kaj Blennow, Archie Campbell, Isabelle Carrié, Julien Delrieu, Karine Fauria, Gema Huesa Rodríguez, Silvia Ingala, Natalie Jenkins, José Luis Molinuevo, Pierre-Jean Ousset, David Porteous, Niels D. Prins, Alina Solomon, Brian D. Tom, Henrik Zetterberg, Marissa Zwan, Craig W. Ritchie, Philip Scheltens, Gerald Luscan, Anthony J. Brookes, Pieter Jelle Visser, for the IMI-EPAD collaborators
Published 2020-01-01