KRASG12C inhibition using MRTX1257: a novel radio-sensitizing partner

by Pierre-Antoine Laurent, Marina Milic, Clément Quevrin, Lydia Meziani, Winchygn Liu, Daphné Morel, Nicolas Signolle, Céline Clémenson, Antonin Levy, Michele Mondini, Eric Deutsch
Published 2023-10-01

TGFβ receptor inhibition unleashes interferon-β production by tumor-associated macrophages and enhances radiotherapy efficacy

by Eric Deutsch, Michele Mondini, Nicolas Signolle, Pauline Hamon, Marine Gerbé De Thoré, Marion Classe, Winchygn Liu, Olivia Bawa, Lydia Meziani, Céline Clémenson, Fabien Milliat
Published 2022-03-01

Serial transplantation unmasks galectin-9 contribution to tumor immune escape in the MB49 murine model

by Valentin Baloche, Julie Rivière, Thi Bao Tram Tran, Aurore Gelin, Olivia Bawa, Nicolas Signolle, M′Boyba Khadija Diop, Philippe Dessen, Stéphanie Beq, Muriel David, Pierre Busson
Published 2021-03-01

A specific immune and lymphatic profile characterizes the pre-metastatic state of the sentinel lymph node in patients with early cervical cancer

by Cédric Balsat, Silvia Blacher, Michael Herfs, Maureen Van de Velde, Nicolas Signolle, Philippe Sauthier, Charles Pottier, Stéphanie Gofflot, Marjolein De Cuypere, Philippe Delvenne, Frédéric Goffin, Agnès Noel, Frédéric Kridelka
Published 2017-02-01

CD103+CD8+ TRM Cells Accumulate in Tumors of Anti-PD-1-Responder Lung Cancer Patients and Are Tumor-Reactive Lymphocytes Enriched with Tc17

by Stéphanie Corgnac, Ines Malenica, Laura Mezquita, Edouard Auclin, Elodie Voilin, Jamila Kacher, Heloise Halse, Laetitia Grynszpan, Nicolas Signolle, Thibault Dayris, Marine Leclerc, Nathalie Droin, Vincent de Montpréville, Olaf Mercier, Pierre Validire, Jean-Yves Scoazec, Christophe Massard, Salem Chouaib, David Planchard, Julien Adam, Benjamin Besse, Fathia Mami-Chouaib
Published 2020-10-01

901 Bacillus Calmette-Guerin can subvert patients antitumor immune response by downregulating HLA-I expression on cancer cells

by Anna Schneider, Francois-Xavier Danlos, Aurélien Marabelle, Laurence Zitvogel, Jean-Charles Soria, Lambros Tselikas, Sandrine Susini, Julien Adam, Mathieu Rouanne, Nicolas Signolle, Ivan Bieche, Yves Allory, Severine Mouraud, Diane Letourneur, Delphine Bredel, Camelia Radulescu, Anne-Gaelle Goubet, Tuan Zea Tan, Amelie Bigorgne, Michael Dussiot, Roman Chabanon, Sophie Vacher, Thierry Lebret, Jean Paul Thiery
Published 2021-11-01

Metabolic features of cancer cells impact immunosurveillance

by Christophe Klein, Diane Damotte, Adrien Joseph, Sebastien Gouy, Marco Alifano, Marie-Caroline Dieu-Nosjean, Guido Kroemer, Eric Deutsch, Antoine Lafarge, Philippe Morice, Julien Adam, Patricia Pautier, Cyrus Chargari, Isabelle Cremer, Catherine Genestie, Pan Juncheng, Michele Mondini, Nizar Labaied, Mauro Loi, Valentina Astesana, Florine Obrist, Norma Bloy, Gautier Stoll, Nicolas Signolle, Judith Michels, Maria Castedo
Published 2021-06-01

Autophagy-mediated metabolic effects of aspirin

by Francesca Castoldi, Juliette Humeau, Isabelle Martins, Sylvie Lachkar, Damarys Loew, Florent Dingli, Sylvère Durand, David Enot, Noëlie Bossut, Alexis Chery, Fanny Aprahamian, Yohann Demont, Paule Opolon, Nicolas Signolle, Allan Sauvat, Michaela Semeraro, Lucillia Bezu, Elisa Elena Baracco, Erika Vacchelli, Jonathan G. Pol, Sarah Lévesque, Norma Bloy, Valentina Sica, Maria Chiara Maiuri, Guido Kroemer, Federico Pietrocola
Published 2020-11-01

BCG therapy downregulates HLA-I on malignant cells to subvert antitumor immune responses in bladder cancer

by Mathieu Rouanne, Julien Adam, Camélia Radulescu, Diane Letourneur, Delphine Bredel, Séverine Mouraud, Anne-Gaëlle Goubet, Marion Leduc, Noah Chen, Tuan Zea Tan, Nicolas Signolle, Amélie Bigorgne, Michael Dussiot, Lambros Tselikas, Sandrine Susini, François-Xavier Danlos, Anna K. Schneider, Roman Chabanon, Sophie Vacher, Ivan Bièche, Thierry Lebret, Yves Allory, Jean-Charles Soria, Nicholas Arpaia, Guido Kroemer, Oliver Kepp, Jean Paul Thiery, Laurence Zitvogel, Aurélien Marabelle
Published 2022-06-01

Safety, recommended dose, efficacy and immune correlates for nintedanib in combination with pembrolizumab in patients with advanced cancers

by Capucine Baldini, Francois-Xavier Danlos, Andreea Varga, Matthieu Texier, Heloise Halse, Severine Mouraud, Lydie Cassard, Stéphane Champiat, Nicolas Signolle, Perrine Vuagnat, Patricia Martin-Romano, Jean-Marie Michot, Rastislav Bahleda, Anas Gazzah, Lisa Boselli, Delphine Bredel, Jonathan Grivel, Chifaou Mohamed-Djalim, Guillaume Escriou, Laetitia Grynszpan, Amelie Bigorgne, Saloomeh Rafie, Alae Abbassi, Vincent Ribrag, Sophie Postel-Vinay, Antoine Hollebecque, Sandrine Susini, Siham Farhane, Ludovic Lacroix, Aurelien Parpaleix, Salim Laghouati, Laurence Zitvogel, Julien Adam, Nathalie Chaput, Jean-Charles Soria, Christophe Massard, Aurelien Marabelle
Published 2022-07-01