Design, Synthesis, and Biological Evaluation of 2-Mercaptobenzoxazole Derivatives as Potential Multi-Kinase Inhibitors

by Mohammed M. Alanazi, Saleh Aldawas, Nawaf A. Alsaif
Published 2023-01-01

A Comprehensive Investigation of Interactions between Antipsychotic Drug Quetiapine and Human Serum Albumin Using Multi-Spectroscopic, Biochemical, and Molecular Modeling Approache...

by Seema Zargar, Tanveer A. Wani, Nawaf A. Alsaif, Arwa Ishaq A. Khayyat
Published 2022-04-01

Design, synthesis, antitumor evaluation, and molecular docking of novel pyrrolo[2,3-d]pyrimidine as multi-kinase inhibitors

by Ashwag S. Alanazi, Tebyan O. Mirgany, Nawaf A. Alsaif, Aisha A. Alsfouk, Mohammed M. Alanazi
Published 2023-06-01

Antiproliferative Activity, Multikinase Inhibition, Apoptosis- Inducing Effects and Molecular Docking of Novel Isatin–Purine Hybrids

by Ashwag S. Alanazi, Tebyan O. Mirgany, Aisha A. Alsfouk, Nawaf A. Alsaif, Mohammed M. Alanazi
Published 2023-03-01

Isolation, characterization, development and evaluation of phytoconstituent based formulation for diabetic neuropathy

by Rashmi Pathak, Neetu Sachan, Atul Kabra, Ashwag S. Alanazi, Mohammed M. Alanazi, Nawaf A. Alsaif, Phool Chandra
Published 2023-08-01

Mechanistic interaction study of 5,6-Dichloro-2-[2-(pyridin-2-yl)ethyl]isoindoline-1,3-dione with bovine serum albumin by spectroscopic and molecular docking approaches

by Mohammed M. Alanazi, Abdulrahman A. Almehizia, Ahmed H. Bakheit, Nawaf A. Alsaif, Hamad M. Alkahtani, Tanveer A. Wani
Published 2019-03-01

Interaction Characterization of a Tyrosine Kinase Inhibitor Erlotinib with a Model Transport Protein in the Presence of Quercetin: A Drug–Protein and Drug–Drug Interaction Investig...

by Tanveer A. Wani, Mohammed M. Alanazi, Nawaf A. Alsaif, Ahmed H. Bakheit, Seema Zargar, Ommalhasan Mohammed Alsalami, Azmat Ali Khan
Published 2022-02-01

Synthesis of Novel Diclofenac Hydrazones: Molecular Docking, Anti-Inflammatory, Analgesic, and Ulcerogenic Activity

by Nawaf A. Alsaif, Mashooq A. Bhat, Mohamed A. Al-Omar, Hanaa M. Al-Tuwajiri, Ahmed M. Naglah, Abdullah Al-Dhfyan
Published 2020-01-01

Gastroprotective evaluation of Medicago sativa L. (Fabaceae) on diabetic rats

by Phool Chandra, Mohammad Kaleem, Neetu Sachan, Rashmi Pathak, Ashwag S. Alanazi, Nawaf A. Alsaif, Sary Alsanea, Bader Alsuwayt, Mohammed M. Alanazi, Atul Kabra
Published 2023-11-01

Synthesis, potential antitumor activity, cell cycle analysis, and multitarget mechanisms of novel hydrazones incorporating a 4-methylsulfonylbenzene scaffold: a molecular docking s...

by Alaa A.-M. Abdel-Aziz, Adel S. El-Azab, Nawaf A. AlSaif, Ahmad J. Obaidullah, Abdulrahman M. Al-Obaid, Ibrahim A. Al-Suwaidan
Published 2021-01-01

Investigation of Novel Benzoxazole-Oxadiazole Derivatives as Effective Anti-Alzheimer’s Agents: In Vitro and In Silico Approaches

by Saeed Anwar, Wajid Rehman, Rafaqat Hussain, Shoaib Khan, Mohammed M. Alanazi, Nawaf A. Alsaif, Yousaf Khan, Shahid Iqbal, Adeela Naz, Muhammad Ali Hashmi
Published 2023-06-01

Novel sulindac derivatives: synthesis, characterisation, evaluation of antioxidant, analgesic, anti-inflammatory, ulcerogenic and COX-2 inhibition activity

by Mashooq A. Bhat, Mohamed A. Al-Omar, Nawaf A. Alsaif, Abdulrahman A. Almehizia, Ahmed M. Naglah, Suhail Razak, Azmat Ali Khan, Naeem Mahmood Ashraf
Published 2020-01-01

Synthesis, antitumor activity, and molecular docking study of 2-cyclopentyloxyanisole derivatives: mechanistic study of enzyme inhibition

by Walaa M. El-Husseiny, Magda A.-A. El-Sayed, Adel S. El-Azab, Nawaf A. AlSaif, Mohammed M. Alanazi, Alaa A.-M. Abdel-Aziz
Published 2020-01-01

Design, synthesis, docking, ADMET studies, and anticancer evaluation of new 3-methylquinoxaline derivatives as VEGFR-2 inhibitors and apoptosis inducers

by Mohammed M. Alanazi, Ibrahim H. Eissa, Nawaf A. Alsaif, Ahmad J. Obaidullah, Wael A. Alanazi, Abdullah F. Alasmari, Hussam Albassam, Hazem Elkady, Alaa Elwan
Published 2021-01-01

Discovery of new VEGFR-2 inhibitors based on bis([1, 2, 4]triazolo)[4,3-a:3',4'-c]quinoxaline derivatives as anticancer agents and apoptosis inducers

by Nawaf A. Alsaif, Mohammed S. Taghour, Mohammed M. Alanazi, Ahmad J. Obaidullah, Abdulrahman A. Al-Mehizia, Manal M. Alanazi, Saleh Aldawas, Alaa Elwan, Hazem Elkady
Published 2021-01-01

Discovery of new 3-methylquinoxalines as potential anti-cancer agents and apoptosis inducers targeting VEGFR-2: design, synthesis, and in silico studies

by Mohammed M. Alanazi, Alaa Elwan, Nawaf A. Alsaif, Ahmad J. Obaidullah, Hamad M. Alkahtani, Abdulrahman A. Al-Mehizia, Sultan M. Alsubaie, Mohammed S. Taghour, Ibrahim H. Eissa
Published 2021-01-01

A New CDK2 Inhibitor with 3-Hydrazonoindolin-2-One Scaffold Endowed with Anti-Breast Cancer Activity: Design, Synthesis, Biological Evaluation, and In Silico Insights

by Mohammad M. Al-Sanea, Ahmad J. Obaidullah, Mohamed E. Shaker, Garri Chilingaryan, Mohammed M. Alanazi, Nawaf A. Alsaif, Hamad M. Alkahtani, Sultan A. Alsubaie, Mohamed A. Abdelgawad
Published 2021-01-01

Deeper Insights on <i>Cnesmone javanica</i> Blume Leaves Extract: Chemical Profiles, Biological Attributes, Network Pharmacology and Molecular Docking

by Ahmad J. Obaidullah, Mohammed M. Alanazi, Nawaf A. Alsaif, Wael A. Mahdi, Omer I. Fantoukh, Abu Montakim Tareq, Saad Ahmed Sami, Ali M. Alqahtani, Talha Bin Emran
Published 2021-04-01

Design, synthesis, and analysis of antiproliferative and apoptosis-inducing activities of nitrile derivatives containing a benzofuran scaffold: EGFR inhibition assay and molecular...

by Salma Fares, Khalid B. Selim, Fatma E. Goda, Magda A. A. El-Sayed, Nawaf A. AlSaif, Mohamed M. Hefnawy, Alaa A.-M. Abdel-Aziz, Adel S. El-Azab
Published 2021-01-01

Carbonic Anhydrase Inhibition Activities of Schiff’s Bases Based on Quinazoline-Linked Benzenesulfonamide

by Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Hazem A. Ghabbour, Silvia Bua, Alessio Nocentini, Hamad M. Alkahtani, Nawaf A. Alsaif, Mohamed H. M. Al-Agamy, Claudiu T. Supuran
Published 2022-11-01