Parkinson’s disease-associated, sex-specific changes in DNA methylation at PARK7 (DJ-1), SLC17A6 (VGLUT2), PTPRN2 (IA-2β), and NR4A2 (NURR1) in cortical neurons

by Joseph Kochmanski, Nathan C. Kuhn, Alison I. Bernstein
Published 2022-09-01

Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology

by Fredric P. Manfredsson, Kelvin C. Luk, Matthew J. Benskey, Aysegul Gezer, Joanna Garcia, Nathan C. Kuhn, Ivette M. Sandoval, Joseph R. Patterson, Alana O'Mara, Reid Yonkers, Jeffrey H. Kordower
Published 2018-04-01

Morphological and behavioral impact of AAV2/5-mediated overexpression of human wildtype alpha-synuclein in the rat nigrostriatal system.

by Sara E Gombash, Fredric P Manfredsson, Christopher J Kemp, Nathan C Kuhn, Sheila M Fleming, Ann E Egan, Laura M Grant, Michelle R Ciucci, Jeffrey P MacKeigan, Caryl E Sortwell
Published 2013-01-01

Epigenetic inactivation of the autophagy–lysosomal system in appendix in Parkinson’s disease

by Juozas Gordevicius, Peipei Li, Lee L. Marshall, Bryan A. Killinger, Sean Lang, Elizabeth Ensink, Nathan C. Kuhn, Wei Cui, Nazia Maroof, Roberta Lauria, Christina Rueb, Juliane Siebourg-Polster, Pierre Maliver, Jared Lamp, Irving Vega, Fredric P. Manfredsson, Markus Britschgi, Viviane Labrie
Published 2021-08-01

Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of α-synuclein-preformed fibril-induced toxicity and motor deficits

by Aysegul O. Gezer, Joseph Kochmanski, Sarah E. VanOeveren, Allyson Cole-Strauss, Christopher J. Kemp, Joseph R. Patterson, Kathryn M. Miller, Nathan C. Kuhn, Danielle E. Herman, Alyssa McIntire, Jack W. Lipton, Kelvin C. Luk, Sheila M. Fleming, Caryl E. Sortwell, Alison I. Bernstein
Published 2020-07-01

Transcriptomic profiling of early synucleinopathy in rats induced with preformed fibrils

by Joseph R. Patterson, Joseph Kochmanski, Anna C. Stoll, Michael Kubik, Christopher J. Kemp, Megan F. Duffy, Kajene Thompson, Jacob W. Howe, Allyson Cole-Strauss, Nathan C. Kuhn, Kathryn M. Miller, Seth Nelson, Christopher U. Onyekpe, John S. Beck, Scott E. Counts, Alison I. Bernstein, Kathy Steece-Collier, Kelvin C. Luk, Caryl E. Sortwell
Published 2024-01-01