262 Preclinical characterization of humanized anti-siglec-15 antibodies that rescue T cells from macrophage-mediated immune suppression

by Lauren Loh, Peter Probst, Huyen Dinh, Sam Lam, Valerie Wall, Francisco Zapata, Darbie Whitman, Ramya Chandrasekaran, Texia Loh, Tom Graddis, Myriam Bouchlaka
Published 2021-11-01

271 Development of OR2805, an anti-CD163 antibody derived from an elite responder to checkpoint inhibitor therapy that relieves immunosuppression caused by M2c macrophages

by Peter Probst, Huyen Dinh, Sam Lam, Valerie Wall, Darbie Whitman, Tom Graddis, Myriam Bouchlaka, Randi Simmons, Meghan Zuck, Ray Fox, Kamal Puri
Published 2021-11-01

276 Discovery and preclinical characterization of anti-LILRB2 antibodies that rescue T cells from macrophage-mediated immune suppression

by Lauren Loh, Peter Probst, Huyen Dinh, Sam Lam, Valerie Wall, Francisco Zapata, Ramya Chandrasekaran, Texia Loh, Tom Graddis, Myriam Bouchlaka, Meghan Zuck, Kamal Puri
Published 2021-11-01

519 OR641 is a novel dual antagonist antibody that targets LILRB1 and LILRB2 inhibitory receptors and promotes a Th1-like immune response

by Peter Probst, Kevin Green, Huyen Dinh, Francisco Zapata, Darbie Whitman, Tom Graddis, Myriam Bouchlaka, Meghan Zuck, Ray Fox, Tatyana Pisarenko, Elsa L Hay, Gajendra Naika, Jacob Heit, Kamal D Puri
Published 2023-11-01