A Non-Canonical Calmodulin Target Motif Comprising a Polybasic Region and Lipidated Terminal Residue Regulates Localization

by Benjamin M. M. Grant, Masahiro Enomoto, Mitsuhiko Ikura, Christopher B. Marshall
Published 2020-04-01

Real-Time In-Cell NMR Reveals the Intracellular Modulation of GTP-Bound Levels of RAS

by Qingci Zhao, Ryu Fujimiya, Satoshi Kubo, Christopher B. Marshall, Mitsuhiko Ikura, Ichio Shimada, Noritaka Nishida
Published 2020-08-01

Crystal structure of NRAS Q61K with a ligand-induced pocket near switch II

by Teklab Gebregiworgis, Jonathan Yui-Lai Chan, Douglas A. Kuntz, Gilbert G. Privé, Christopher B. Marshall, Mitsuhiko Ikura
Published 2024-06-01

p120RasGAP is a mediator of rho pathway activation and tumorigenicity in the DLD1 colorectal cancer cell line.

by Shawna L Organ, Josephine Hai, Nikolina Radulovich, Christopher B Marshall, Lisa Leung, Takehiko Sasazuki, Senji Shirasawa, Chang-Qi Zhu, Roya Navab, Mitsuhiko Ikura, Ming-Sound Tsao
Published 2014-01-01

Plasma redox imbalance caused by albumin oxidation promotes lung-predominant NETosis and pulmonary cancer metastasis

by Minoru Inoue, Ryota Nakashima, Masahiro Enomoto, Yuhki Koike, Xiao Zhao, Kenneth Yip, Shao Hui Huang, John N. Waldron, Mitsuhiko Ikura, Fei-Fei Liu, Scott V. Bratman
Published 2018-11-01

Evolution of AF6-RAS association and its implications in mixed-lineage leukemia

by Matthew J. Smith, Elizabeth Ottoni, Noboru Ishiyama, Marilyn Goudreault, André Haman, Claus Meyer, Monika Tucholska, Genevieve Gasmi-Seabrook, Serena Menezes, Rob C. Laister, Mark D. Minden, Rolf Marschalek, Anne-Claude Gingras, Trang Hoang, Mitsuhiko Ikura
Published 2017-10-01

Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions

by Noboru Ishiyama, Ritu Sarpal, Megan N. Wood, Samantha K. Barrick, Tadateru Nishikawa, Hanako Hayashi, Anna B. Kobb, Annette S. Flozak, Alex Yemelyanov, Rodrigo Fernandez-Gonzalez, Shigenobu Yonemura, Deborah E. Leckband, Cara J. Gottardi, Ulrich Tepass, Mitsuhiko Ikura
Published 2018-11-01

Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation

by Yoshihito Kano, Teklab Gebregiworgis, Christopher B. Marshall, Nikolina Radulovich, Betty P. K. Poon, Jonathan St-Germain, Jonathan D. Cook, Ivette Valencia-Sama, Benjamin M. M. Grant, Silvia Gabriela Herrera, Jinmin Miao, Brian Raught, Meredith S. Irwin, Jeffrey E. Lee, Jen Jen Yeh, Zhong-Yin Zhang, Ming-Sound Tsao, Mitsuhiko Ikura, Michael Ohh
Published 2019-01-01

The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors

by Teklab Gebregiworgis, Yoshihito Kano, Jonathan St-Germain, Nikolina Radulovich, Molly L. Udaskin, Ahmet Mentes, Richard Huang, Betty P. K. Poon, Wenguang He, Ivette Valencia-Sama, Claire M. Robinson, Melissa Huestis, Jinmin Miao, Jen Jen Yeh, Zhong-Yin Zhang, Meredith S. Irwin, Jeffrey E. Lee, Ming-Sound Tsao, Brian Raught, Christopher B. Marshall, Michael Ohh, Mitsuhiko Ikura
Published 2021-11-01