Disease Modification in Multiple Sclerosis by Flupirtine—Results of a Randomized Placebo Controlled Phase II Trial

by Jan Dörr, Klaus-Dieter Wernecke, Jens Würfel, Jens Würfel, Judith Bellmann-Strobl, Judith Bellmann-Strobl, Volker Siffrin, Muriel B. Sättler, Mikael Simons, Mikael Simons, Mikael Simons, Andreas Linsa, Andreas Linsa, Hayrettin Tumani, Hayrettin Tumani, Friedemann Paul, Friedemann Paul, Friedemann Paul
Published 2018-10-01

ATUM-FIB microscopy for targeting and multiscale imaging of rare events in mouse cortex

by Georg Kislinger, Helmut Gnägi, Martin Kerschensteiner, Mikael Simons, Thomas Misgeld, Martina Schifferer
Published 2020-12-01

Cholesterol depletion reduces aggregation of amyloid-beta peptide in hippocampal neurons

by Anja Schneider, Walter Schulz-Schaeffer, Tobias Hartmann, Jörg B. Schulz, Mikael Simons
Published 2006-09-01

Multiscale ATUM-FIB Microscopy Enables Targeted Ultrastructural Analysis at Isotropic Resolution

by Georg Kislinger, Helmut Gnägi, Martin Kerschensteiner, Mikael Simons, Thomas Misgeld, Martina Schifferer
Published 2020-07-01

Cell visco-elasticity measured with AFM and optical trapping at sub-micrometer deformations.

by Schanila Nawaz, Paula Sánchez, Kai Bodensiek, Sai Li, Mikael Simons, Iwan A T Schaap
Published 2012-01-01

A fluorescence microscopy-based protocol for volumetric measurement of lysolecithin lesion-associated de- and re-myelination in mouse brain

by Mar Bosch-Queralt, Vini Tiwari, Alkmini Damkou, Lenka Vaculčiaková, Ioannis Alexopoulos, Mikael Simons
Published 2022-03-01

Targeted ablation of oligodendrocytes triggers axonal damage.

by Aniket Ghosh, Natalia Manrique-Hoyos, Aaron Voigt, Jörg B Schulz, Mario Kreutzfeldt, Doron Merkler, Mikael Simons
Published 2011-01-01

Dynamics of the Peripheral Membrane Protein P2 from Human Myelin Measured by Neutron Scattering--A Comparison between Wild-Type Protein and a Hinge Mutant.

by Saara Laulumaa, Tuomo Nieminen, Mari Lehtimäki, Shweta Aggarwal, Mikael Simons, Michael M Koza, Ilpo Vattulainen, Petri Kursula, Francesca Natali
Published 2015-01-01

Dissociation of microdissected mouse brain tissue for artifact free single-cell RNA sequencing

by Lu Liu, Simon Besson-Girard, Hao Ji, Katrin Gehring, Buket Bulut, Tuğberk Kaya, Fumere Usifo, Mikael Simons, Ozgun Gokce
Published 2021-06-01

Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin

by Nicolas Snaidero, Caroline Velte, Matti Myllykoski, Arne Raasakka, Alexander Ignatev, Hauke B. Werner, Michelle S. Erwig, Wiebke Möbius, Petri Kursula, Klaus-Armin Nave, Mikael Simons
Published 2017-01-01

In vivo identification of apoptotic and extracellular vesicle-bound live cells using image-based deep learning

by Jan Kranich, Nikolaos-Kosmas Chlis, Lisa Rausch, Ashretha Latha, Martina Schifferer, Tilman Kurz, Agnieszka Foltyn-Arfa Kia, Mikael Simons, Fabian J. Theis, Thomas Brocker
Published 2020-01-01

Dual-Phase β-Amyloid PET Captures Neuronal Injury and Amyloidosis in Corticobasal Syndrome

by Julia Schmitt, Carla Palleis, Julia Sauerbeck, Marcus Unterrainer, Stefanie Harris, Catharina Prix, Endy Weidinger, Sabrina Katzdobler, Olivia Wagemann, Adrian Danek, Leonie Beyer, Boris-Stephan Rauchmann, Boris-Stephan Rauchmann, Axel Rominger, Axel Rominger, Axel Rominger, Mikael Simons, Mikael Simons, Mikael Simons, Peter Bartenstein, Peter Bartenstein, Robert Perneczky, Robert Perneczky, Robert Perneczky, Robert Perneczky, Christian Haass, Christian Haass, Christian Haass, Johannes Levin, Johannes Levin, Johannes Levin, Günter U. Höglinger, Günter U. Höglinger, Günter U. Höglinger, Matthias Brendel, Matthias Brendel, the German Imaging Initiative for Tauopathies (GII4T)
Published 2021-05-01

A global in vivo Drosophila RNAi screen identifies a key role of ceramide phosphoethanolamine for glial ensheathment of axons.

by Aniket Ghosh, Tina Kling, Nicolas Snaidero, Julio L Sampaio, Andrej Shevchenko, Heribert Gras, Bart Geurten, Martin C Göpfert, Jörg B Schulz, Aaron Voigt, Mikael Simons
Published 2013-01-01

Myelin membrane assembly is driven by a phase transition of myelin basic proteins into a cohesive protein meshwork.

by Shweta Aggarwal, Nicolas Snaidero, Gesa Pähler, Steffen Frey, Paula Sánchez, Markus Zweckstetter, Andreas Janshoff, Anja Schneider, Marie-Theres Weil, Iwan A T Schaap, Dirk Görlich, Mikael Simons
Published 2013-01-01

Ganglioside lipidomics of CNS myelination using direct infusion shotgun mass spectrometry

by Martina Arends, Melanie Weber, Cyrus Papan, Markus Damm, Michal A. Surma, Christopher Spiegel, Minou Djannatian, Shengrong Li, Lisa Connell, Ludger Johannes, Martina Schifferer, Christian Klose, Mikael Simons
Published 2022-11-01

Large-scale screen for modifiers of ataxin-3-derived polyglutamine-induced toxicity in Drosophila.

by Hannes VoSSfeldt, Malte Butzlaff, Katja PrüSSing, Róisín-Ana Ní Chárthaigh, Peter Karsten, Anne Lankes, Sabine Hamm, Mikael Simons, Boris Adryan, Jörg B Schulz, Aaron Voigt
Published 2012-01-01

Two adhesive systems cooperatively regulate axon ensheathment and myelin growth in the CNS

by Minou Djannatian, Sebastian Timmler, Martina Arends, Manja Luckner, Marie-Theres Weil, Ioannis Alexopoulos, Nicolas Snaidero, Bettina Schmid, Thomas Misgeld, Wiebke Möbius, Martina Schifferer, Elior Peles, Mikael Simons
Published 2019-10-01

Microglia-mediated demyelination protects against CD8+ T cell-driven axon degeneration in mice carrying PLP defects

by Janos Groh, Tassnim Abdelwahab, Yogita Kattimani, Michaela Hörner, Silke Loserth, Viktoria Gudi, Robert Adalbert, Fabian Imdahl, Antoine-Emmanuel Saliba, Michael Coleman, Martin Stangel, Mikael Simons, Rudolf Martini
Published 2023-10-01

Spatial Transcriptomics-correlated Electron Microscopy maps transcriptional and ultrastructural responses to brain injury

by Peter Androvic, Martina Schifferer, Katrin Perez Anderson, Ludovico Cantuti-Castelvetri, Hanyi Jiang, Hao Ji, Lu Liu, Garyfallia Gouna, Stefan A. Berghoff, Simon Besson-Girard, Johanna Knoferle, Mikael Simons, Ozgun Gokce
Published 2023-07-01

Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases

by Marie-Theres Weil, Wiebke Möbius, Anne Winkler, Torben Ruhwedel, Claudia Wrzos, Elisa Romanelli, Jeffrey L. Bennett, Lukas Enz, Norbert Goebels, Klaus-Armin Nave, Martin Kerschensteiner, Nicole Schaeren-Wiemers, Christine Stadelmann, Mikael Simons
Published 2016-07-01