Clozapine counteracts a ketamine-induced depression of hippocampal-prefrontal neuroplasticity and alters signaling pathway phosphorylation.

by Marion Rame, Dorian Caudal, Esther Schenker, Per Svenningsson, Michael Spedding, Thérèse M Jay, Bill P Godsil
Published 2017-01-01

Inhibition of β-Glucocerebrosidase Activity Preserves Motor Unit Integrity in a Mouse Model of Amyotrophic Lateral Sclerosis

by Alexandre Henriques, Mylene Huebecker, Hélène Blasco, Céline Keime, Christian R. Andres, Philippe Corcia, David A. Priestman, Frances M. Platt, Michael Spedding, Jean-Philippe Loeffler
Published 2017-07-01

The age-performance relationship in the general population and strategies to delay age related decline in performance

by Geoffroy Berthelot, Stacey Johnson, Philippe Noirez, Juliana Antero, Adrien Marck, François-Denis Desgorces, Fabien Pifferi, Patrick A. Carter, Michael Spedding, Archana Singh Manoux, Jean-François Toussaint
Published 2019-12-01

Ambroxol Hydrochloride Improves Motor Functions and Extends Survival in a Mouse Model of Familial Amyotrophic Lateral Sclerosis

by Alexandra Bouscary, Alexandra Bouscary, Cyril Quessada, Cyril Quessada, Althéa Mosbach, Althéa Mosbach, Noëlle Callizot, Michael Spedding, Jean-Philippe Loeffler, Jean-Philippe Loeffler, Alexandre Henriques, Alexandre Henriques, Alexandre Henriques
Published 2019-08-01

Sphingolipid Metabolism Is Dysregulated at Transcriptomic and Metabolic Levels in the Spinal Cord of an Animal Model of Amyotrophic Lateral Sclerosis

by Alexandre Henriques, Alexandre Henriques, Alexandre Henriques, Vincent Croixmarie, Alexandra Bouscary, Alexandra Bouscary, Althéa Mosbach, Althéa Mosbach, Céline Keime, Claire Boursier-Neyret, Bernard Walter, Michael Spedding, Jean-Philippe Loeffler, Jean-Philippe Loeffler
Published 2018-01-01

GM1 ganglioside exerts protective effects against glutamate‐excitotoxicity via its oligosaccharide in wild‐type and amyotrophic lateral sclerosis motor neurons

by Giulia Lunghi, Erika Di Biase, Emma Veronica Carsana, Alexandre Henriques, Noelle Callizot, Laura Mauri, Maria Grazia Ciampa, Luigi Mari, Nicoletta Loberto, Massimo Aureli, Sandro Sonnino, Michael Spedding, Elena Chiricozzi, Maria Fazzari
Published 2023-12-01

Acute Stress Affects the Expression of Hippocampal Mu Oscillations in an Age-Dependent Manner

by Samir Takillah, Samir Takillah, Samir Takillah, Samir Takillah, Samir Takillah, Jérémie Naudé, Steve Didienne, Claude Sebban, Claude Sebban, Brigitte Decros, Brigitte Decros, Esther Schenker, Michael Spedding, Alexandre Mourot, Jean Mariani, Jean Mariani, Philippe Faure
Published 2017-09-01

Are We Reaching the Limits of Homo sapiens?

by Adrien Marck, Adrien Marck, Juliana Antero, Geoffroy Berthelot, Geoffroy Berthelot, Geoffroy Berthelot, Guillaume Saulière, Jean-Marc Jancovici, Valérie Masson-Delmotte, Gilles Boeuf, Michael Spedding, Éric Le Bourg, Jean-François Toussaint, Jean-François Toussaint, Jean-François Toussaint
Published 2017-10-01

Phenotypical Screening on Neuronal Plasticity in Hippocampal-Prefrontal Cortex Connectivity Reveals an Antipsychotic with a Novel Profile

by Michael Spedding, Claude Sebban, Thérèse M. Jay, Cyril Rocher, Brigitte Tesolin-Decros, Paul Chazot, Esther Schenker, Gabor Szénási, György I. Lévay, Katalin Megyeri, Jozsef Barkóczy, Laszlo G. Hársing, Ian Thomson, Mark O. Cunningham, Miles A. Whittington, Lori-An Etherington, Jeremy J. Lambert, Ferenc A. Antoni, Istvan Gacsályi
Published 2022-03-01

Corrigendum to “Future directions for the discovery of natural product-derived immunomodulating drugs: An IUPHAR positional review” [Pharmacol. Res. 177 (2022) 106076]

by Cherry L. Wainwright, Mauro M. Teixeira, David L. Adelson, Eric J. Buenz, Bruno David, Keith B. Glaser, Yuka Harata-Lee, Melanie-Jayne R. Howes, Angelo A. Izzo, Pasquale Maffia, Alejandro M.S. Mayer, Claire Mazars, David J. Newman, Eimear Nic Lughadha, Adriano M.C. Pimenta, John A.A. Parra, Zhipeng Qu, Hanyuan Shen, Michael Spedding, Jean-Luc Wolfender
Published 2022-06-01

Future directions for the discovery of natural product-derived immunomodulating drugs: an IUPHAR positional review

by Cherry L. Wainwright, Mauro M. Teixeira, David L. Adelson, Fernão C. Braga, Eric J. Buenz, Priscilla R.V. Campana, Bruno David, Keith B. Glaser, Yuka Harata-Lee, Melanie-Jayne R. Howes, Angelo A. Izzo, Pasquale Maffia, Alejandro M.S. Mayer, Claire Mazars, David J. Newman, Eimear Nic Lughadha, Rodrigo M. Pádua, Adriano M.C. Pimenta, John A.A. Parra, Zhipeng Qu, Hanyuan Shen, Michael Spedding, Jean-Luc Wolfender
Published 2022-03-01