Connecting Sarcomere Protein Mutations to Pathogenesis in Cardiomyopathies: The Development of ‘Disease in a Dish’ Models

by Rebecca Zaunbrecher, Michael Regnier
Published 2016-11-01

Axial and radial forces of cross-bridges depend on lattice spacing.

by C David Williams, Michael Regnier, Thomas L Daniel
Published 2010-12-01

Elastic energy storage and radial forces in the myofilament lattice depend on sarcomere length.

by C David Williams, Michael Regnier, Thomas L Daniel
Published 2012-01-01

Filament compliance influences cooperative activation of thin filaments and the dynamics of force production in skeletal muscle.

by Bertrand C W Tanner, Thomas L Daniel, Michael Regnier
Published 2012-01-01

Sarcomere lattice geometry influences cooperative myosin binding in muscle.

by Bertrand C W Tanner, Thomas L Daniel, Michael Regnier
Published 2007-07-01

Conformational sampling of CMT-2D associated GlyRS mutations

by Matthew Carter Childers, Michael Regnier, Mark Bothwell, Alec S.T. Smith
Published 2022-01-01

Effect of Myosin Isoforms on Cardiac Muscle Twitch of Mice, Rats and Humans

by Momcilo Prodanovic, Michael A. Geeves, Corrado Poggesi, Michael Regnier, Srboljub M. Mijailovich
Published 2022-01-01

Simvastatin provides long‐term improvement of left ventricular function and prevents cardiac fibrosis in muscular dystrophy

by Min J. Kim, Kenneth L. Bible, Michael Regnier, Marvin E. Adams, Stanley C. Froehner, Nicholas P. Whitehead
Published 2019-03-01

Efficacy and muscle safety assessment of fukutin-related protein gene therapy

by Halli Benasutti, Joseph W. Maricelli, Jane Seto, John Hall, Christine Halbert, Jacqueline Wicki, Lydia Heusgen, Nicholas Purvis, Michael Regnier, David C. Lin, Buel D. Rodgers, Jeffrey S. Chamberlain
Published 2023-09-01

Modulating the tension-time integral of the cardiac twitch prevents dilated cardiomyopathy in murine hearts

by Joseph D. Powers, Kristina B. Kooiker, Allison B. Mason, Abigail E. Teitgen, Galina V. Flint, Jil C. Tardiff, Steven D. Schwartz, Andrew D. McCulloch, Michael Regnier, Jennifer Davis, Farid Moussavi-Harami
Published 2020-10-01

Gene Therapy Rescues Cardiac Dysfunction in Duchenne Muscular Dystrophy Mice by Elevating Cardiomyocyte Deoxy-Adenosine Triphosphate

by Stephen C. Kolwicz, Jr., PhD, John K. Hall, PhD, Farid Moussavi-Harami, MD, Xiolan Chen, PhD, Stephen D. Hauschka, PhD, Jeffrey S. Chamberlain, PhD, Michael Regnier, PhD, Guy L. Odom, PhD
Published 2019-11-01

Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment

by Anthony M. Pettinato, Dasom Yoo, Jennifer VanOudenhove, Yu-Sheng Chen, Rachel Cohn, Feria A. Ladha, Xiulan Yang, Ketan Thakar, Robert Romano, Nicolas Legere, Emily Meredith, Paul Robson, Michael Regnier, Justin L. Cotney, Charles E. Murry, J. Travis Hinson
Published 2021-05-01

Post-translational modification patterns on β-myosin heavy chain are altered in ischemic and nonischemic human hearts

by Maicon Landim-Vieira, Matthew C Childers, Amanda L Wacker, Michelle Rodriquez Garcia, Huan He, Rakesh Singh, Elizabeth A Brundage, Jamie R Johnston, Bryan A Whitson, P Bryant Chase, Paul ML Janssen, Michael Regnier, Brandon J Biesiadecki, J Renato Pinto, Michelle S Parvatiyar
Published 2022-05-01

Isolation and Mechanical Measurements of Myofibrils from Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

by Josè Manuel Pioner, Alice W. Racca, Jordan M. Klaiman, Kai-Chun Yang, Xuan Guan, Lil Pabon, Veronica Muskheli, Rebecca Zaunbrecher, Jesse Macadangdang, Mark Y. Jeong, David L. Mack, Martin K. Childers, Deok-Ho Kim, Chiara Tesi, Corrado Poggesi, Charles E. Murry, Michael Regnier
Published 2016-06-01

Translation of Cardiac Myosin Activation With 2-Deoxy-ATP to Treat Heart Failure Via an Experimental Ribonucleotide Reductase-Based Gene Therapy

by Kassandra S. Thomson, PhD, Guy L. Odom, PhD, Charles E. Murry, MD, PhD, Gregory G. Mahairas, PhD, Farid Moussavi-Harami, MD, Sam L. Teichman, MD, Xiaolan Chen, PhD, Stephen D. Hauschka, PhD, Jeffrey S. Chamberlain, PhD, Michael Regnier, PhD
Published 2016-12-01

Variants in ACTC1 underlie distal arthrogryposis accompanied by congenital heart defects

by Jessica X. Chong, Matthew Carter Childers, Colby T. Marvin, Anthony J. Marcello, Hernan Gonorazky, Lili-Naz Hazrati, James J. Dowling, Fatema Al Amrani, Yasemin Alanay, Yolanda Nieto, Miguel Á Marín Gabriel, Arthur S. Aylsworth, Kati J. Buckingham, Kathryn M. Shively, Olivia Sommers, Kailyn Anderson, Michael Regnier, Michael J. Bamshad
Published 2023-07-01

Optical Investigation of Action Potential and Calcium Handling Maturation of hiPSC-Cardiomyocytes on Biomimetic Substrates

by Josè Manuel Pioner, Lorenzo Santini, Chiara Palandri, Daniele Martella, Flavia Lupi, Marianna Langione, Silvia Querceto, Bruno Grandinetti, Valentina Balducci, Patrizia Benzoni, Sara Landi, Andrea Barbuti, Federico Ferrarese Lupi, Luca Boarino, Laura Sartiani, Chiara Tesi, David L. Mack, Michael Regnier, Elisabetta Cerbai, Camilla Parmeggiani, Corrado Poggesi, Cecilia Ferrantini, Raffaele Coppini
Published 2019-08-01

Corrigendum: Calcium handling maturation and adaptation to increased substrate stiffness in human iPSC-derived cardiomyocytes: the impact of full-length dystrophin deficiency

by Josè Manuel Pioner, Lorenzo Santini, Chiara Palandri, Marianna Langione, Bruno Grandinetti, Silvia Querceto, Daniele Martella, Daniele Martella, Costanza Mazzantini, Beatrice Scellini, Lucrezia Giammarino, Flavia Lupi, Francesco Mazzarotto, Francesco Mazzarotto, Aoife Gowran, Davide Rovina, Rosaria Santoro, Giulio Pompilio, Giulio Pompilio, Chiara Tesi, Camilla Parmeggiani, Camilla Parmeggiani, Michael Regnier, Elisabetta Cerbai, David L. Mack, Corrado Poggesi, Cecilia Ferrantini, Raffaele Coppini
Published 2023-06-01

Calcium handling maturation and adaptation to increased substrate stiffness in human iPSC-derived cardiomyocytes: The impact of full-length dystrophin deficiency

by Josè Manuel Pioner, Lorenzo Santini, Chiara Palandri, Marianna Langione, Bruno Grandinetti, Silvia Querceto, Daniele Martella, Daniele Martella, Costanza Mazzantini, Beatrice Scellini, Lucrezia Giammarino, Flavia Lupi, Francesco Mazzarotto, Francesco Mazzarotto, Aoife Gowran, Davide Rovina, Rosaria Santoro, Giulio Pompilio, Giulio Pompilio, Chiara Tesi, Camilla Parmeggiani, Camilla Parmeggiani, Michael Regnier, Elisabetta Cerbai, David L. Mack, Corrado Poggesi, Cecilia Ferrantini, Raffaele Coppini
Published 2022-11-01

Novel Adult-Onset Systolic Cardiomyopathy Due to MYH7 E848G Mutation in Patient-Derived Induced Pluripotent Stem Cells

by Kai-Chun Yang, MD, Astrid Breitbart, MD, Willem J. De Lange, PhD, Peter Hofsteen, PhD, Akiko Futakuchi-Tsuchida, BS, Joy Xu, MSE, Cody Schopf, BS, Maria V. Razumova, PhD, Alex Jiao, PhD, Robert Boucek, MD, Lil Pabon, PhD, Hans Reinecke, PhD, Deok-Ho Kim, PhD, J. Carter Ralphe, MD, Michael Regnier, PhD, Charles E. Murry, MD, PhD
Published 2018-12-01