Clinical Results of Hypomethylating Agents in AML Treatment

by Marjan Cruijsen, Michael Lübbert, Pierre Wijermans, Gerwin Huls
Published 2014-12-01

Absence of early platelet increment in healthy mice during decitabine treatment

by Juliane Baumann, Markus Spindler, Yannick Throm, Michael Lübbert, Markus Bender
Published 2022-12-01

Targeting DNA hypermethylation: Computational modeling of DNA demethylation treatment of acute myeloid leukemia

by Jens Przybilla, Lydia Hopp, Michael Lübbert, Markus Loeffler, Joerg Galle
Published 2017-10-01

Epigenetics in Pancreatic Ductal Adenocarcinoma: Impact on Biology and Utilization in Diagnostics and Treatment

by Asmaa Elrakaybi, Dietrich A. Ruess, Michael Lübbert, Michael Quante, Heiko Becker
Published 2022-11-01

The AML-associated K313 mutation enhances C/EBPα activity by leading to C/EBPα overexpression

by Ian Edward Gentle, Isabel Moelter, Mohamed Tarek Badr, Konstanze Döhner, Michael Lübbert, Georg Häcker
Published 2021-07-01

The epigenetics of breast cancer – Opportunities for diagnostics, risk stratification and therapy

by Rieke Schröder, Anna-Lena Illert, Thalia Erbes, Christian Flotho, Michael Lübbert, Jesús Duque-Afonso
Published 2022-06-01

Impact of the Injection Site on Growth Characteristics, Phenotype and Sensitivity towards Cytarabine of Twenty Acute Leukaemia Patient-Derived Xenograft Models

by Julia Schueler, Gabriele Greve, Dorothée Lenhard, Milena Pantic, Anna Edinger, Eva Oswald, Michael Lübbert
Published 2020-05-01

Epigenetic priming of AML blasts for all-trans retinoic acid-induced differentiation by the HDAC class-I selective inhibitor entinostat.

by Nadja Blagitko-Dorfs, Yi Jiang, Jesús Duque-Afonso, Jan Hiller, Arzu Yalcin, Gabriele Greve, Mahmoud Abdelkarim, Björn Hackanson, Michael Lübbert
Published 2013-01-01

Long-term decitabine/retinoic acid maintenance treatment in an elderly sAML patient with high-risk genetics

by Nora Rebeka Javorniczky, Olga Grishina, Inga Hund, Milena Pantic, Dietmar Pfeifer, Claudia Schmoor, Johanna Thomas, Justus Duyster, Heiko Becker, Michael Lübbert
Published 2023-11-01

Functional Characterization of Transforming Growth Factor-β Signaling in Dasatinib Resistance and Pre-BCR⁺ Acute Lymphoblastic Leukemia

by Gila Mostufi-Zadeh-Haghighi, Pia Veratti, Kyra Zodel, Gabriele Greve, Miguel Waterhouse, Robert Zeiser, Michael L. Cleary, Michael Lübbert, Jesús Duque-Afonso
Published 2023-08-01

Transcriptional upregulation of p21/WAF/Cip1 in myeloid leukemic blasts expressing AML1-ETO

by Tobias Berg, Manfred Fliegauf, Jan Burger, Martin S. Staege, Shaohua Liu, Natalia Martinez, Olaf Heidenreich, Stefan Burdach, Torsten Haferlach, Milton H. Werner, Michael Lübbert
Published 2008-11-01

Fetal hemoglobin induction during decitabine treatment of elderly patients with high-risk myelodysplastic syndrome or acute myeloid leukemia: a potential dynamic biomarker of outco...

by Julia Stomper, Gabriele Ihorst, Stefan Suciu, Philipp N. Sander, Heiko Becker, Pierre W. Wijermans, Christoph Plass, Dieter Weichenhan, Emmanuel Bissé, Rainer Claus, Michael Lübbert
Published 2019-01-01

Impact of MLL5 expression on decitabine efficacy and DNA methylation in acute myeloid leukemia

by Haiyang Yun, Frederik Damm, Damian Yap, Adrian Schwarzer, Anuhar Chaturvedi, Nidhi Jyotsana, Michael Lübbert, Lars Bullinger, Konstanze Döhner, Robert Geffers, Samuel Aparicio, R. Keith Humphries, Arnold Ganser, Michael Heuser
Published 2014-09-01

Bisulfite-free epigenomics and genomics of single cells through methylation-sensitive restriction

by Christoph Niemöller, Julius Wehrle, Julian Riba, Rainer Claus, Nathalie Renz, Janika Rhein, Sabine Bleul, Juliane M. Stosch, Justus Duyster, Christoph Plass, Pavlo Lutsik, Daniel B. Lipka, Michael Lübbert, Heiko Becker
Published 2021-02-01

Molecular Genetic Characterization of Individual Cancer Cells Isolated via Single-Cell Printing.

by Julian Riba, Nathalie Renz, Christoph Niemöller, Sabine Bleul, Dietmar Pfeifer, Juliane M Stosch, Klaus H Metzeler, Björn Hackanson, Michael Lübbert, Justus Duyster, Peter Koltay, Roland Zengerle, Rainer Claus, Stefan Zimmermann, Heiko Becker
Published 2016-01-01

Parameters detected by geriatric and quality of life assessment in 195 older patients with myelodysplastic syndromes and acute myeloid leukemia are highly predictive for outcome

by Barbara Deschler, Gabriele Ihorst, Uwe Platzbecker, Ulrich Germing, Eva März, Marcelo de Figuerido, Kurt Fritzsche, Peter Haas, Helmut R. Salih, Aristoteles Giagounidis, Dominik Selleslag, Boris Labar, Theo de Witte, Pierre Wijermans, Michael Lübbert
Published 2013-02-01

The antileukemic activity of decitabine upon PML/RARA-negative AML blasts is supported by all-trans retinoic acid: in vitro and in vivo evidence for cooperation

by Ruth Meier, Gabriele Greve, Dennis Zimmer, Helena Bresser, Bettina Berberich, Ralitsa Langova, Julia Stomper, Anne Rubarth, Lars Feuerbach, Daniel B. Lipka, Joschka Hey, Björn Grüning, Benedikt Brors, Justus Duyster, Christoph Plass, Heiko Becker, Michael Lübbert
Published 2022-08-01

P480: DNMT AND HDAC INHIBITION INDUCES IMMUNOGENIC NEOANTIGENS FROM HUMAN ENDOGENOUS RETROVIRAL ELEMENT-DERIVED TRANSCRIPTS

by Ashish Goyal, Jens Bauer, Joschka Hey, Dimitris Papageorgiou, Ekaterina Stepanova, Michael Daskalakis, Marissa Dubbelaar, Boris Klimovich, Melanie Maerklin, Malte Roerden, Oliver Muecke, Hans-Georg Rammensee, Fabricio Loayza-Puch, Jeroen Krijgsveld, Michael Lübbert, Juliane Walz, Christoph Plass
Published 2023-08-01

A multicenter phase II trial of decitabine as first-line treatment for older patients with acute myeloid leukemia judged unfit for induction chemotherapy

by Michael Lübbert, Björn H. Rüter, Rainer Claus, Claudia Schmoor, Mathias Schmid, Ulrich Germing, Andrea Kuendgen, Volker Rethwisch, Arnold Ganser, Uwe Platzbecker, Oliver Galm, Wolfram Brugger, Gerhard Heil, Björn Hackanson, Barbara Deschler, Konstanze Döhner, Anne Hagemeijer, Pierre W. Wijermans, Hartmut Döhner
Published 2012-03-01

Cluster of differentiation 33 single nucleotide polymorphism rs12459419 is a predictive factor in patients with <i>nucleophosmin1</i>-mutated acute myeloid leukemia receiving gemtu...

by Katrin Teich, Julia Krzykalla, Silke Kapp-Schwoerer, Verena I. Gaidzik, Richard F. Schlenk, Peter Paschka, Daniela Weber, Walter Fiedler, Michael W.M. Kühn, Thomas Schroeder, Karin Mayer, Michael Lübbert, Dhanya Ramachandran, Axel Benner, Arnold Ganser, Hartmut Döhner, Michael Heuser, Konstanze Döhner, Felicitas Thol
Published 2021-05-01