Diketomorpholines: Synthetic Accessibility and Utilization

by Lan Phuong Vu, Michael Gütschow
Published 2021-12-01

A Short Peptide Inhibitor as an Activity-Based Probe for Matriptase-2

by Martin Mangold, Michael Gütschow, Marit Stirnberg
Published 2018-05-01

Promiscuous Ligands from Experimentally Determined Structures, Binding Conformations, and Protein Family-Dependent Interaction Hotspots

by Erik Gilberg, Michael Gütschow, Jürgen Bajorath
Published 2019-01-01

Synthesis and Crystal Structure of Benzyl [(1S)-1-(5-amino-1,3,4-oxadiazol-2-yl)-2-phenylethyl]carbamate

by Reik Löser, Martin Nieger, Michael Gütschow
Published 2012-08-01

Microplate assay for quantitative determination of cathepsin activities in viable cells using derivatives of 4-methoxy-β-naphthylamide

by Anke Rüttger, Jürgen Mollenhauer, Reik Löser, Michael Gütschow, Bernd Wiederanders
Published 2006-10-01

Cholesterol esterase action on human high density lipoproteins and inhibition studies: detection by MALDI-TOF MS

by Olaf Zschörnig, Markus Pietsch, Rosemarie Süß, Jürgen Schiller, Michael Gütschow
Published 2005-04-01

E3 Ligase Ligands in Successful PROTACs: An Overview of Syntheses and Linker Attachment Points

by Aleša Bricelj, Christian Steinebach, Robert Kuchta, Michael Gütschow, Izidor Sosič
Published 2021-07-01

Structure–Stability Relationship of NLRP3 Inflammasome-Inhibiting Sulfonylureas

by Tim Keuler, Dominic Ferber, Michael Marleaux, Matthias Geyer, Michael Gütschow
Published 2022-02-01

Calcium-sensing receptors signal constitutive macropinocytosis and facilitate the uptake of NOD2 ligands in macrophages

by Johnathan Canton, Daniel Schlam, Christian Breuer, Michael Gütschow, Michael Glogauer, Sergio Grinstein
Published 2016-04-01

Convergent Synthesis of Two Fluorescent Ebselen-Coumarin Heterodimers

by Jim Küppers, Anna Christina Schulz-Fincke, Jerzy Palus, Mirosław Giurg, Jacek Skarżewski, Michael Gütschow
Published 2016-07-01

Solubility Enhanced Formulation Approaches to Overcome Oral Delivery Obstacles of PROTACs

by Florian Pöstges, Kevin Kayser, Jan Appelhaus, Marius Monschke, Michael Gütschow, Christian Steinebach, Karl G. Wagner
Published 2023-01-01

3,1-Benzothiazines, 1,4-Benzodioxines and 1,4-Benzoxazines as Inhibitors of Matriptase-2: Outcome of a Focused Screening Approach

by Polya G. Roydeva, Anna-Madeleine Beckmann, Marit Stirnberg, Jožko Cesar, Danijel Kikelj, Janez Ilaš, Michael Gütschow
Published 2016-01-01

Development of Fluorescent and Biotin Probes Targeting NLRP3

by Tim Keuler, Karl Gatterdam, Anil Akbal, Marta Lovotti, Michael Marleaux, Matthias Geyer, Eicke Latz, Michael Gütschow
Published 2021-04-01

Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes

by Jakub Benýšek, Michal Buša, Petra Rubešová, Jindřich Fanfrlík, Martin Lepšík, Jiří Brynda, Zuzana Matoušková, Ulrike Bartz, Martin Horn, Michael Gütschow, Michael Mareš
Published 2022-12-01

Cell Type-Specific Anti-Viral Effects of Novel SARS-CoV-2 Main Protease Inhibitors

by Nina Geiger, Viktoria Diesendorf, Valeria Roll, Eva-Maria König, Helena Obernolte, Katherina Sewald, Julian Breidenbach, Thanigaimalai Pillaiyar, Michael Gütschow, Christa E. Müller, Jochen Bodem
Published 2023-02-01

Label-Free Whole Cell Biosensing for High-Throughput Discovery of Activators and Inhibitors Targeting G Protein-Activated Inwardly Rectifying Potassium Channels

by Katrin M. Krebs, Eva M. Pfeil, Katharina Simon, Manuel Grundmann, Felix Häberlein, Oscar M. Bautista-Aguilera, Michael Gütschow, C. David Weaver, Bernd K. Fleischmann, Evi Kostenis
Published 2018-11-01

Development of an active-site titrant for SARS-CoV-2 main protease as an indispensable tool for evaluating enzyme kinetics

by Rabea Voget, Julian Breidenbach, Tobias Claff, Alexandra Hingst, Katharina Sylvester, Christian Steinebach, Lan Phuong Vu, Renato H. Weiße, Ulrike Bartz, Norbert Sträter, Christa E. Müller, Michael Gütschow
Published 2024-05-01

Design and Synthesis of Multi-Functional Ligands through Hantzsch Reaction: Targeting Ca²⁺ Channels, Activating Nrf2 and Possessing Cathepsin S Inhibitory, and Antioxida...

by Irene Pachón-Angona, Paul J. Bernard, Alexey Simakov, Maciej Maj, Krzysztof Jozwiak, Anna Novotna, Carina Lemke, Michael Gütschow, Helene Martin, María-Jesús Oset-Gasque, José-Marco Contelles, Lhassane Ismaili
Published 2024-01-01

Preclinical Evaluation of a Novel Series of Polyfluorinated Thalidomide Analogs in Drug-Resistant Multiple Myeloma

by Blaire E. Barton, Matthew K. Collins, Cindy H. Chau, Hyoyoung Choo-Wosoba, David J. Venzon, Christian Steinebach, Kathleen M. Garchitorena, Bhruga Shah, Eric L. Sarin, Michael Gütschow, William D. Figg
Published 2024-06-01

Antiangiogenic Activity and in Silico Cereblon Binding Analysis of Novel Thalidomide Analogs

by Megan L. Peach, Shaunna L. Beedie, Cindy H. Chau, Matthew K. Collins, Suzana Markolovic, Weiming Luo, David Tweedie, Christian Steinebach, Nigel H. Greig, Michael Gütschow, Neil Vargesson, Marc C. Nicklaus, William D. Figg
Published 2020-12-01