Therapeutic targeting of measles virus polymerase with ERDRP-0519 suppresses all RNA synthesis activity.

by Robert M Cox, Julien Sourimant, Mugunthan Govindarajan, Michael G Natchus, Richard K Plemper
Published 2021-02-01

Influenza A virus resistance to 4'-fluorouridine coincides with viral attenuation in vitro and in vivo.

by Carolin M Lieber, Hae-Ji Kang, Megha Aggarwal, Nicole A Lieberman, Elizabeth B Sobolik, Jeong-Joong Yoon, Michael G Natchus, Robert M Cox, Alexander L Greninger, Richard K Plemper
Published 2024-02-01

Asymmetric synthesis of host-directed inhibitors of myxoviruses

by Terry W. Moore, Kasinath Sana, Dan Yan, Pahk Thepchatri, John M. Ndungu, Manohar T. Saindane, Mark A. Lockwood, Michael G. Natchus, Dennis C. Liotta, Richard K. Plemper, James P. Snyder, Aiming Sun
Published 2013-01-01

Small-molecule polymerase inhibitor protects non-human primates from measles and reduces shedding

by Kevin Wittwer, Danielle E. Anderson, Kristin Pfeffermann, Robert M. Cox, Josef D. Wolf, Sabine Santibanez, Annette Mankertz, Roland Plesker, Zachary M. Sticher, Alexander A. Kolkykhalov, Michael G. Natchus, Christian K. Pfaller, Richard K. Plemper, Veronika von Messling
Published 2021-09-01

4′-Fluorouridine inhibits alphavirus replication and infection in vitro and in vivo

by Peiqi Yin, Nicholas A. May, Laura Sandra Lello, Atef Fayed, M. Guston Parks, Adam M. Drobish, Sainan Wang, Meghan Andrews, Zachary Sticher, Alexander A. Kolykhalov, Michael G. Natchus, George R. Painter, Andres Merits, Margaret Kielian, Thomas E. Morrison
Published 2024-06-01

SARS-CoV-2 VOC type and biological sex affect molnupiravir efficacy in severe COVID-19 dwarf hamster model

by Carolin M. Lieber, Robert M. Cox, Julien Sourimant, Josef D. Wolf, Kate Juergens, Quynh Phung, Manohar T. Saindane, Meghan K. Smith, Zachary M. Sticher, Alexander A. Kalykhalov, Michael G. Natchus, George R. Painter, Kaori Sakamoto, Alexander L. Greninger, Richard K. Plemper
Published 2022-07-01

Comparing molnupiravir and nirmatrelvir/ritonavir efficacy and the effects on SARS-CoV-2 transmission in animal models

by Robert M. Cox, Carolin M. Lieber, Josef D. Wolf, Amirhossein Karimi, Nicole A. P. Lieberman, Zachary M. Sticher, Pavitra Roychoudhury, Meghan K. Andrews, Rebecca E. Krueger, Michael G. Natchus, George R. Painter, Alexander A. Kolykhalov, Alexander L. Greninger, Richard K. Plemper
Published 2023-08-01

4'-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses.

by Carolin M Lieber, Megha Aggarwal, Jeong-Joong Yoon, Robert M Cox, Hae-Ji Kang, Julien Sourimant, Mart Toots, Scott K Johnson, Cheryl A Jones, Zachary M Sticher, Alexander A Kolykhalov, Manohar T Saindane, Stephen M Tompkins, Oliver Planz, George R Painter, Michael G Natchus, Kaori Sakamoto, Richard K Plemper
Published 2023-04-01

Therapeutic mitigation of measles-like immune amnesia and exacerbated disease after prior respiratory virus infections in ferrets

by Robert M. Cox, Josef D. Wolf, Nicole A. Lieberman, Carolin M. Lieber, Hae-Ji Kang, Zachary M. Sticher, Jeong-Joong Yoon, Meghan K. Andrews, Mugunthan Govindarajan, Rebecca E. Krueger, Elizabeth B. Sobolik, Michael G. Natchus, Andrew T. Gewirtz, Rik L. deSwart, Alexander A. Kolykhalov, Khan Hekmatyar, Kaori Sakamoto, Alexander L. Greninger, Richard K. Plemper
Published 2024-02-01