Exploiting Cell-Based Assays to Accelerate Drug Development for G Protein-Coupled Receptors

by Yuxin Wu, Niels Jensen, Moritz J. Rossner, Michael C. Wehr
Published 2024-05-01

Improved Split TEV GPCR β-arrestin-2 Recruitment Assays via Systematic Analysis of Signal Peptide and β-arrestin Binding Motif Variants

by Yuxin Wu, Isabelle V. von Hauff, Niels Jensen, Moritz J. Rossner, Michael C. Wehr
Published 2022-12-01

Disturbed clockwork resetting in Sharp-1 and Sharp-2 single and double mutant mice.

by Moritz J Rossner, Henrik Oster, Sven P Wichert, Lisa Reinecke, Michael C Wehr, Johannes Reinecke, Gregor Eichele, Reshma Taneja, Klaus-Armin Nave
Published 2008-07-01

Split-cre complementation indicates coincident activity of different genes in vivo.

by Johannes Hirrlinger, Anja Scheller, Petra G Hirrlinger, Beate Kellert, Wannan Tang, Michael C Wehr, Sandra Goebbels, Andreas Reichenbach, Rolf Sprengel, Moritz J Rossner, Frank Kirchhoff
Published 2009-01-01

Profiling of ERBB receptors and downstream pathways reveals selectivity and hidden properties of ERBB4 antagonists

by Lukša Popović, Jan P. Wintgens, Yuxin Wu, Ben Brankatschk, Sascha Menninger, Carsten Degenhart, Niels Jensen, Sven P. Wichert, Bert Klebl, Moritz J. Rossner, Michael C. Wehr
Published 2024-02-01

Mice lacking the circadian modulators SHARP1 and SHARP2 display altered sleep and mixed state endophenotypes of psychiatric disorders.

by Paul C Baier, Magdalena M Brzózka, Ali Shahmoradi, Lisa Reinecke, Christina Kroos, Sven P Wichert, Henrik Oster, Michael C Wehr, Reshma Taneja, Johannes Hirrlinger, Moritz J Rossner
Published 2014-01-01

Expression of Lineage Transcription Factors Identifies Differences in Transition States of Induced Human Oligodendrocyte Differentiation

by Florian J. Raabe, Marius Stephan, Jan Benedikt Waldeck, Verena Huber, Damianos Demetriou, Nirmal Kannaiyan, Sabrina Galinski, Laura V. Glaser, Michael C. Wehr, Michael J. Ziller, Andrea Schmitt, Peter Falkai, Moritz J. Rossner
Published 2022-01-01

Add-on spironolactone as antagonist of the NRG1-ERBB4 signaling pathway for the treatment of schizophrenia: Study design and methodology of a multicenter randomized, placebo-contro...

by Alkomiet Hasan, Astrid Roeh, Stefan Leucht, Berthold Langguth, Maximilian Hansbauer, Tatiana Oviedo-Salcedo, Sophie K. Kirchner, Irina Papazova, Lisa Löhrs, Elias Wagner, Isabel Maurus, Wolfgang Strube, Moritz J. Rossner, Michael C. Wehr, Ingrid Bauer, Stephan Heres, Claudia Leucht, Peter M. Kreuzer, Stephanie Zimmermann, Thomas Schneider-Axmann, Thomas Görlitz, Susanne Karch, Silvia Egert-Schwender, Beate Schossow, Philipp Rothe, Peter Falkai
Published 2020-03-01