Optimization of a Three-Dimensional Culturing Method for Assessing the Impact of Cisplatin on Notch Signaling in Head and Neck Squamous Cell Carcinoma (HNSCC)

by Alinda Anameriç, Arkadiusz Czerwonka, Matthias Nees
Published 2023-11-01

Modulation of Notch Signaling by Small-Molecular Compounds and Its Potential in Anticancer Studies

by Arkadiusz Czerwonka, Joanna Kałafut, Matthias Nees
Published 2023-09-01

Segmentation of Image Data from Complex Organotypic 3D Models of Cancer Tissues with Markov Random Fields.

by Sean Robinson, Laurent Guyon, Jaakko Nevalainen, Mervi Toriseva, Malin Åkerfelt, Matthias Nees
Published 2015-01-01

A high-content image analysis approach for quantitative measurements of chemosensitivity in patient-derived tumor microtissues

by Ilmari Ahonen, Malin Åkerfelt, Mervi Toriseva, Eva Oswald, Julia Schüler, Matthias Nees
Published 2017-07-01

The Notch inhibitor, FLI-06, increases the chemosensitivity of head and neck Squamous cell carcinoma cells to taxanes-based treatment

by Arkadiusz Czerwonka, Joanna Kałafut, Shaoxia Wang, Alinda Anameric, Alicja Przybyszewska-Podstawka, Mervi Toriseva, Matthias Nees
Published 2024-08-01

Factors Affecting Intracellular Delivery and Release of Hydrophilic Versus Hydrophobic Cargo from Mesoporous Silica Nanoparticles on 2D and 3D Cell Cultures

by Diti Desai, Malin Åkerfelt, Neeraj Prabhakar, Mervi Toriseva, Tuomas Näreoja, Jixi Zhang, Matthias Nees, Jessica M. Rosenholm
Published 2018-11-01

Context Matters: NOTCH Signatures and Pathway in Cancer Progression and Metastasis

by Julia O. Misiorek, Alicja Przybyszewska-Podstawka, Joanna Kałafut, Beata Paziewska, Katarzyna Rolle, Adolfo Rivero-Müller, Matthias Nees
Published 2021-01-01

Shooting at Moving and Hidden Targets—Tumour Cell Plasticity and the Notch Signalling Pathway in Head and Neck Squamous Cell Carcinomas

by Joanna Kałafut, Arkadiusz Czerwonka, Alinda Anameriç, Alicja Przybyszewska-Podstawka, Julia O. Misiorek, Adolfo Rivero-Müller, Matthias Nees
Published 2021-12-01

Quantification of dynamic morphological drug responses in 3D organotypic cell cultures by automated image analysis.

by Ville Härmä, Hannu-Pekka Schukov, Antti Happonen, Ilmari Ahonen, Johannes Virtanen, Harri Siitari, Malin Åkerfelt, Jyrki Lötjönen, Matthias Nees
Published 2014-01-01

CD73 facilitates EMT progression and promotes lung metastases in triple-negative breast cancer

by Nataliia Petruk, Sanni Tuominen, Malin Åkerfelt, Jesse Mattsson, Jouko Sandholm, Matthias Nees, Gennady G. Yegutkin, Arja Jukkola, Johanna Tuomela, Katri S. Selander
Published 2021-03-01

A comprehensive panel of three-dimensional models for studies of prostate cancer growth, invasion and drug responses.

by Ville Härmä, Johannes Virtanen, Rami Mäkelä, Antti Happonen, John-Patrick Mpindi, Matias Knuuttila, Pekka Kohonen, Jyrki Lötjönen, Olli Kallioniemi, Matthias Nees
Published 2010-01-01

Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer

by Virginia Murillo-Garzón, Irantzu Gorroño-Etxebarria, Malin Åkerfelt, Mikael Christer Puustinen, Lea Sistonen, Matthias Nees, James Carton, Jonathan Waxman, Robert M. Kypta
Published 2018-05-01

Evaluation of the anticancer activity of RIN-1, a Notch signaling modulator, in head and neck squamous cell carcinoma

by Arkadiusz Czerwonka, Joanna Kałafut, Shaoxia Wang, Alinda Anameric, Alicja Przybyszewska-Podstawka, Jesse Mattsson, Mahtab Karbasian, Doriane Le Manach, Mervi Toriseva, Matthias Nees
Published 2023-08-01

The effect of matrices on the gene expression profile of patient-derived head and neck carcinoma cells for in vitro therapy testing

by Aini Hyytiäinen, Katja Korelin, Mervi Toriseva, Tommy Wilkman, Satu Kainulainen, Karri Mesimäki, Johannes Routila, Sami Ventelä, Heikki Irjala, Matthias Nees, Ahmed Al-Samadi, Tuula Salo
Published 2023-07-01

Validation of Novel Biomarkers for Prostate Cancer Progression by the Combination of Bioinformatics, Clinical and Functional Studies.

by Saeid Alinezhad, Riina-Minna Väänänen, Jesse Mattsson, Yifeng Li, Terhi Tallgrén, Natalia Tong Ochoa, Anders Bjartell, Malin Åkerfelt, Pekka Taimen, Peter J Boström, Kim Pettersson, Matthias Nees
Published 2016-01-01

Correction: Validation of Novel Biomarkers for Prostate Cancer Progression by the Combination of Bioinformatics, Clinical and Functional Studies.

by Saeid Alinezhad, Riina-Minna Väänänen, Jesse Mattsson, Yifeng Li, Terhi Tallgrén, Natalia Tong Ochoa, Anders Bjartell, Malin Åkerfelt, Pekka Taimen, Peter J Boström, Kim Pettersson, Matthias Nees
Published 2016-01-01

Optimization of Invasion-Specific Effects of Betulin Derivatives on Prostate Cancer Cells through Lead Development.

by Ville Härmä, Raisa Haavikko, Johannes Virtanen, Ilmari Ahonen, Hannu-Pekka Schukov, Sami Alakurtti, Enkhee Purev, Heiko Rischer, Jari Yli-Kauhaluoma, Vânia M Moreira, Matthias Nees, Kirsi-Marja Oksman-Caldentey
Published 2015-01-01

Correction: GTI: A Novel Algorithm for Identifying Outlier Gene Expression Profiles from Integrated Microarray Datasets.

by John Patrick Mpindi, Henri Sara, Saija Haapa-Paananen, Sami Kilpinen, Tommi Pisto, Elmar Bucher, Kalle Ojala, Kristiina Iljin, Paula Vainio, Mari Björkman, Santosh Gupta, Pekka Kohonen, Matthias Nees, Olli Kallioniemi
Published 2011-01-01

GTI: a novel algorithm for identifying outlier gene expression profiles from integrated microarray datasets.

by John Patrick Mpindi, Henri Sara, Saija Haapa-Paananen, Sami Kilpinen, Tommi Pisto, Elmar Bucher, Kalle Ojala, Kristiina Iljin, Paula Vainio, Mari Björkman, Santosh Gupta, Pekka Kohonen, Matthias Nees, Olli Kallioniemi
Published 2011-01-01

Assessment of targeted therapy opportunities in sinonasal cancers using patient-derived functional tumor models

by Noora Lehtinen, Janne Suhonen, Kiesha Rice, Eetu Välimäki, Mervi Toriseva, Johannes Routila, Perttu Halme, Melissa Rahi, Heikki Irjala, Ilmo Leivo, Markku Kallajoki, Matthias Nees, Teijo Kuopio, Sami Ventelä, Juha K. Rantala
Published 2024-06-01