80 Association of in situ T-cell receptor diversity and tumor adjacent immune cells to checkpoint inhibitor response in head and neck squamous cell carcinoma (HNSCC)

by Matthew Loya, Homer Adams, Omar Jabado, Patrick Franken, Nora Pencheva, Mark Fereshteh, Li Fan, Anantharaman Muthuswamy, Angelo Harris, Susan Sun, Gabrielle Suppa
Published 2023-11-01

562 Combined spatial and transcriptomic analysis identifies immune microenvironment factors associated with checkpoint inhibition response in triple negative breast cancer

by Wei Han, Matthew Loya, Omar Jabado, Patrick Franken, Nora Pencheva, Mark Fereshteh, Chung-Wein Lee, Clifton Drew, Louise Koopman, Angelo Harris, Mohammed Qutaish, Brooke Robertson
Published 2023-11-01

928 A translational approach to catalog pancreatic cancer heterogeneity using spatial genomics in large patient cohorts for target validation and rational combination selection

by Omar Jabado, Suzana Couto, Patricia Coutinho de Souza, Kate Sasser, Mark Fereshteh, Li Fan, Angelo Harris, Arturo Chaparro, Mohammed Qutaish, Han Si, Jan-Hermen Dannenberg
Published 2021-11-01

561 DuoBody®-PD-L1×4–1BB (GEN1046) induces superior immune-cell activation, cytokine production and cytotoxicity by combining PD-L1 blockade with conditional 4–1BB co-stimulation...

by Maria Jure-Kunkel, Rachelle Kosoff, Mark Fereshteh, Alexander Muik, Isil Altintas, Friederike Gieseke, Kristina Schödel, Theodora Salcedo, Saskia Burm, Aras Toker, Lena Kranz, Mathias Vormehr, David Eisel, Özlem Türeci, Esther Breij, Tahamtan Ahmadi, Ugur Sahin
Published 2020-11-01

Critical role of kinase activity of hematopoietic progenitor kinase 1 in anti-tumor immune surveillance.

by Jinqi Liu, Joshua Curtin, Dan You, Stephen Hillerman, Bifang Li-Wang, Rukiye Eraslan, Jenny Xie, Jesse Swanson, Ching-Ping Ho, Simone Oppenheimer, Bethanne M Warrack, Colleen A McNaney, David M Nelson, Jordan Blum, Taeg Kim, Mark Fereshteh, Michael Reily, Petia Shipkova, Anwar Murtaza, Miguel Sanjuan, John T Hunt, Luisa Salter-Cid
Published 2019-01-01

DuoBody-CD40x4-1BB induces dendritic-cell maturation and enhances T-cell activation through conditional CD40 and 4-1BB agonist activity

by Maria Jure-Kunkel, Homer C Adams III, Kate Sasser, Mark Fereshteh, Alexander Muik, Isil Altintas, Friederike Gieseke, Aras Toker, Özlem Türeci, Tahamtan Ahmadi, Ugur Sahin, Dennis Verzijl, Kristina B Schoedel, Jordan M Blum, Bianca Sänger, Saskia M Burm, Eliana Stanganello, Vanessa M Spires, Fulvia Vascotto, Juliane Quinkhardt, Mustafa Diken, David P E Satijn, Sebastian Kreiter, Esther C W Breij
Published 2022-06-01