Interaction of the transactivation domain of B-Myb with the TAZ2 domain of the coactivator p300: molecular features and properties of the complex.

by Ojore Oka, Lorna C Waters, Sarah L Strong, Nuvjeevan S Dosanjh, Vaclav Veverka, Frederick W Muskett, Philip S Renshaw, Karl-Heinz Klempnauer, Mark D Carr
Published 2012-01-01

Identification and characterisation of anti-IL-13 inhibitory single domain antibodies provides new insights into receptor selectivity and attractive opportunities for drug discover...

by Kayleigh Walker, Roberta Baravalle, Rachel Holyfield, Jacqueline Kalms, Jacqueline Kalms, Helena Wright, Chitra Seewooruthun, Frederick W. Muskett, Anthony Scott-Tucker, Andy Merritt, Alistair Henry, Alastair D. G. Lawson, Gareth Hall, Christine Prosser, Christine Prosser, Mark D. Carr
Published 2023-07-01

Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR.

by Daniel Stöppler, Alex Macpherson, Susanne Smith-Penzel, Nicolas Basse, Fabien Lecomte, Hervé Deboves, Richard D Taylor, Tim Norman, John Porter, Lorna C Waters, Marta Westwood, Ben Cossins, Katharine Cain, James White, Robert Griffin, Christine Prosser, Sebastian Kelm, Amy H Sullivan, David Fox, Mark D Carr, Alistair Henry, Richard Taylor, Beat H Meier, Hartmut Oschkinat, Alastair D Lawson
Published 2018-05-01

Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action

by Mark Austin, Daniel Burschowsky, Denice T.Y. Chan, Lesley Jenkinson, Stuart Haynes, Agata Diamandakis, Chitra Seewooruthun, Alexandra Addyman, Sebastian Fiedler, Stephanie Ryman, Jessica Whitehouse, Louise H. Slater, Andreas V. Hadjinicolaou, Uzi Gileadi, Ellen Gowans, Yoko Shibata, Michelle Barnard, Teresa Kaserer, Pooja Sharma, Nadia M. Luheshi, Robert W. Wilkinson, Tristan J. Vaughan, Sarah V. Holt, Vincenzo Cerundolo, Mark D. Carr, Maria A. T. Groves
Published 2020-01-01

Cross-Reactive SARS-CoV-2 Neutralizing Antibodies From Deep Mining of Early Patient Responses

by Georgia Bullen, Jacob D. Galson, Gareth Hall, Pedro Villar, Lien Moreels, Line Ledsgaard, Giada Mattiuzzo, Emma M. Bentley, Edward W. Masters, David Tang, Sophie Millett, Danielle Tongue, Richard Brown, Ioannis Diamantopoulos, Kothai Parthiban, Claire Tebbutt, Rachael Leah, Krishna Chaitanya, Sandra Ergueta-Carballo, Deividas Pazeraitis, Sachin B. Surade, Omodele Ashiru, Lucia Crippa, Richard Cowan, Matthew W. Bowler, Jamie I. Campbell, Wing-Yiu Jason Lee, Mark D. Carr, David Matthews, Paul Pfeffer, Simon E. Hufton, Kovilen Sawmynaden, Jane Osbourn, John McCafferty, Aneesh Karatt-Vellatt
Published 2021-06-01