Naringenin Inhibition of the Pseudomonas aeruginosa Quorum Sensing Response Is Based on Its Time-Dependent Competition With N-(3-Oxo-dodecanoyl)-L-homoserine Lactone for LasR Bindi...

by Sara Hernando-Amado, Manuel Alcalde-Rico, Manuel Alcalde-Rico, Manuel Alcalde-Rico, Teresa Gil-Gil, José R. Valverde, José L. Martínez
Published 2020-02-01

The MexJK Multidrug Efflux Pump Is Not Involved in Acquired or Intrinsic Antibiotic Resistance in <em>Pseudomonas aeruginosa</em>, but Modulates the Bacterial Quorum Sensing Respon...

by Rafael Amieva, Teresa Gil-Gil, José Luis Martínez, Manuel Alcalde-Rico
Published 2022-07-01

Multidrug efflux pumps at the crossroad between antibiotic resistance and bacterial virulence

by Manuel Alcalde-Rico, Sara Hernando-Amado, Paula Blanco, Jose L Martinez
Published 2016-09-01

Metabolic Compensation of Fitness Costs Is a General Outcome for Antibiotic-Resistant <italic toggle="yes">Pseudomonas aeruginosa</italic> Mutants Overexpressing Efflux Pumps

by Jorge Olivares Pacheco, Carolina Alvarez-Ortega, Manuel Alcalde Rico, José Luis Martínez
Published 2017-09-01

Ceftazidime/avibactam resistance is associated with PER-3-producing ST309 lineage in Chilean clinical isolates of non-carbapenemase producing Pseudomonas aeruginosa

by Katherine D. Soto, Manuel Alcalde-Rico, Manuel Alcalde-Rico, Manuel Alcalde-Rico, Manuel Alcalde-Rico, Juan A. Ugalde, Juan A. Ugalde, Jorge Olivares-Pacheco, Jorge Olivares-Pacheco, Valeria Quiroz, Valeria Quiroz, Bárbara Brito, Lina M. Rivas, Lina M. Rivas, José M. Munita, José M. Munita, Patricia C. García, Patricia C. García, Patricia C. García, Aniela Wozniak, Aniela Wozniak, Aniela Wozniak
Published 2024-06-01

Acquisition of resistance to ceftazidime-avibactam during infection treatment in Pseudomonas aeruginosa through D179Y mutation in one of two blaKPC-2 gene copies without losing car...

by Patricia García, Patricia García, Patricia García, Bárbara Brito, Manuel Alcalde-Rico, Manuel Alcalde-Rico, Manuel Alcalde-Rico, José M. Munita, José M. Munita, Jose R. W. Martínez, Jose R. W. Martínez, Jorge Olivares-Pacheco, Jorge Olivares-Pacheco, Valeria Quiroz, Valeria Quiroz, Aniela Wozniak, Aniela Wozniak, Aniela Wozniak
Published 2022-09-01

Role of the Multidrug Resistance Efflux Pump MexCD-OprJ in the Pseudomonas aeruginosa Quorum Sensing Response

by Manuel Alcalde-Rico, Jorge Olivares-Pacheco, Carolina Alvarez-Ortega, Miguel Cámara, José Luis Martínez
Published 2018-11-01

A whole‐cell hypersensitive biosensor for beta‐lactams based on the AmpR‐AmpC regulatory circuit from the Antarctic Pseudomonas sp. IB20

by Sebastián Higuera‐Llantén, Manuel Alcalde‐Rico, Felipe Vasquez‐Ponce, Claudia Ibacache‐Quiroga, Jesús Blazquez, Jorge Olivares‐Pacheco
Published 2024-01-01

Mutations in the efflux pump regulator MexZ shift tissue colonization by Pseudomonas aeruginosa to a state of antibiotic tolerance

by Pablo Laborda, Signe Lolle, Sara Hernando-Amado, Manuel Alcalde-Rico, Kasper Aanæs, José Luis Martínez, Søren Molin, Helle Krogh Johansen
Published 2024-03-01

Role of the multi-drug efflux systems on the baseline susceptibility to ceftazidime/avibactam and ceftolozane/tazobactam in clinical isolates of non-carbapenemase-producing carbape...

by María José Contreras-Gómez, María José Contreras-Gómez, María José Contreras-Gómez, José R. W. Martinez, José R. W. Martinez, Lina Rivas, Lina Rivas, Roberto Riquelme-Neira, Roberto Riquelme-Neira, Roberto Riquelme-Neira, Juan A. Ugalde, Juan A. Ugalde, Aniela Wozniak, Aniela Wozniak, Aniela Wozniak, Patricia García, Patricia García, Patricia García, José M. Munita, José M. Munita, Jorge Olivares-Pacheco, Jorge Olivares-Pacheco, Manuel Alcalde-Rico, Manuel Alcalde-Rico, Manuel Alcalde-Rico
Published 2022-10-01

Bacterial Multidrug Efflux Pumps: Much More Than Antibiotic Resistance Determinants

by Paula Blanco, Sara Hernando-Amado, Jose Antonio Reales-Calderon, Fernando Corona, Felipe Lira, Manuel Alcalde-Rico, Alejandra Bernardini, Maria Blanca Sanchez, Jose Luis Martinez
Published 2016-02-01

Genetic characterization of clinically relevant class 1 integrons carried by multidrug resistant bacteria (MDRB) isolated from the gut microbiota of highly antibiotic treated Salmo...

by Felipe Vásquez-Ponce, Sebastián Higuera-Llantén, Juan Parás-Silva, Nicolás Gamboa-Acuña, Jimena Cortés, Andrés Opazo-Capurro, Juan A. Ugalde, Manuel Alcalde-Rico, Jorge Olivares-Pacheco
Published 2022-06-01

Isolation of an Extensively Drug-Resistant Pseudomonas aeruginosa exoS+/O4 Strain Belonging to the “High-Risk” Clone ST654 and Coproducer of NDM-1 and the Novel VIM-80

by Andrés Opazo-Capurro, Felipe Morales-León, Christian Jerez, Jorge Olivares-Pacheco, Manuel Alcalde-Rico, Paulina González-Muñoz, Helia Bello-Toledo, Adriana Cardenas-Arias, Fernanda Esposito, Nilton Lincopán, Vijna Illesca, Gerardo González-Rocha
Published 2022-10-01

Dynamics of the MRSA Population in a Chilean Hospital: a Phylogenomic Analysis (2000–2016)

by José R. W. Martínez, Paul J. Planet, Maria Spencer-Sandino, Lina Rivas, Lorena Díaz, Ahmed M. Moustafa, Ana Quesille-Villalobos, Roberto Riquelme-Neira, Manuel Alcalde-Rico, Blake Hanson, Lina P. Carvajal, Sandra Rincón, Jinnethe Reyes, Marusella Lam, Juan F. Calderon, Rafael Araos, Patricia García, César A. Arias, José M. Munita
Published 2023-08-01