Chondroitin Sulfate Proteoglycan 4 and Its Potential As an Antibody Immunotherapy Target across Different Tumor Types

by Kristina M. Ilieva, Kristina M. Ilieva, Anthony Cheung, Anthony Cheung, Silvia Mele, Giulia Chiaruttini, Silvia Crescioli, Merope Griffin, Mano Nakamura, Mano Nakamura, James F. Spicer, Sophia Tsoka, Katie E. Lacy, Andrew N. J. Tutt, Andrew N. J. Tutt, Sophia N. Karagiannis, Sophia N. Karagiannis
Published 2018-01-01

IgE Antibodies against Cancer: Efficacy and Safety

by Jitesh Chauhan, Alex J. McCraw, Mano Nakamura, Gabriel Osborn, Heng Sheng Sow, Vivienne F. Cox, Chara Stavraka, Debra H. Josephs, James F. Spicer, Sophia N. Karagiannis, Heather J. Bax
Published 2020-10-01

Immune mediator expression signatures are associated with improved outcome in ovarian carcinoma

by Mano Nakamura, Heather J. Bax, Daniele Scotto, Elmira Amiri Souri, Sam Sollie, Robert J. Harris, Niklas Hammar, Goran Walldius, Anna Winship, Sharmistha Ghosh, Ana Montes, James F. Spicer, Mieke Van Hemelrijck, Debra H. Josephs, Katie E. Lacy, Sophia Tsoka, Sophia N. Karagiannis
Published 2019-06-01

IgE Activates Monocytes from Cancer Patients to Acquire a Pro-Inflammatory Phenotype

by Mano Nakamura, Elmira Amiri Souri, Gabriel Osborn, Roman Laddach, Jitesh Chauhan, Chara Stavraka, Sara Lombardi, Anna Black, Atousa Khiabany, Duaa O. Khair, Mariangela Figini, Anna Winship, Sharmistha Ghosh, Ana Montes, James F. Spicer, Heather J. Bax, Debra H. Josephs, Katie E. Lacy, Sophia Tsoka, Sophia N. Karagiannis
Published 2020-11-01

Basophils from Cancer Patients Respond to Immune Stimuli and Predict Clinical Outcome

by Heather J. Bax, Jitesh Chauhan, Chara Stavraka, Atousa Khiabany, Mano Nakamura, Giulia Pellizzari, Kristina M. Ilieva, Sara Lombardi, Hannah J. Gould, Christopher J. Corrigan, Stephen J. Till, Sidath Katugampola, Paul S. Jones, Claire Barton, Anna Winship, Sharmistha Ghosh, Ana Montes, Debra H. Josephs, James F. Spicer, Sophia N. Karagiannis
Published 2020-07-01

B Cells in Patients With Melanoma: Implications for Treatment With Checkpoint Inhibitor Antibodies

by Zena N. Willsmore, Robert J. Harris, Silvia Crescioli, Khuluud Hussein, Helen Kakkassery, Deepika Thapa, Anthony Cheung, Anthony Cheung, Jitesh Chauhan, Heather J. Bax, Heather J. Bax, Alicia Chenoweth, Alicia Chenoweth, Roman Laddach, Roman Laddach, Gabriel Osborn, Alexa McCraw, Ricarda M. Hoffmann, Mano Nakamura, Jenny L. Geh, Alastair MacKenzie-Ross, Ciaran Healy, Sophia Tsoka, James F. Spicer, Sophie Papa, Sophie Papa, Linda Barber, Katie E. Lacy, Sophia N. Karagiannis, Sophia N. Karagiannis
Published 2021-01-01

Safety and anti-tumour activity of the IgE antibody MOv18 in patients with advanced solid tumours expressing folate receptor-alpha: a phase I trial

by James Spicer, Bristi Basu, Ana Montes, Udai Banerji, Rebecca Kristeleit, Rowan Miller, Gareth J. Veal, Christopher J. Corrigan, Stephen J. Till, Mariangela Figini, Silvana Canevari, Claire Barton, Paul Jones, Sarah Mellor, Simon Carroll, Chris Selkirk, George Nintos, Vineet Kwatra, Ionut-Gabriel Funingana, Gary Doherty, Hannah J. Gould, Giulia Pellizzari, Mano Nakamura, Kristina M. Ilieva, Atousa Khiabany, Chara Stavraka, Jitesh Chauhan, Cheryl Gillett, Sarah Pinder, Heather J. Bax, Debra H. Josephs, Sophia N. Karagiannis
Published 2023-07-01

Combining Immune Checkpoint Inhibitors: Established and Emerging Targets and Strategies to Improve Outcomes in Melanoma

by Duaa O. Khair, Heather J. Bax, Heather J. Bax, Silvia Mele, Silvia Crescioli, Giulia Pellizzari, Atousa Khiabany, Mano Nakamura, Robert J. Harris, Elise French, Ricarda M. Hoffmann, Ricarda M. Hoffmann, Iwan P. Williams, Anthony Cheung, Anthony Cheung, Benjamin Thair, Charlie T. Beales, Emma Touizer, Adrian W. Signell, Nahrin L. Tasnova, James F. Spicer, Debra H. Josephs, Debra H. Josephs, Jenny L. Geh, Alastair MacKenzie Ross, Ciaran Healy, Sophie Papa, Katie E. Lacy, Sophia N. Karagiannis
Published 2019-03-01

Anti-cancer pro-inflammatory effects of an IgE antibody targeting the melanoma-associated antigen chondroitin sulfate proteoglycan 4

by Jitesh Chauhan, Melanie Grandits, Lais C. G. F. Palhares, Silvia Mele, Mano Nakamura, Jacobo López-Abente, Silvia Crescioli, Roman Laddach, Pablo Romero-Clavijo, Anthony Cheung, Chara Stavraka, Alicia M. Chenoweth, Heng Sheng Sow, Giulia Chiaruttini, Amy E. Gilbert, Tihomir Dodev, Alexander Koers, Giulia Pellizzari, Kristina M. Ilieva, Francis Man, Niwa Ali, Carl Hobbs, Sara Lombardi, Daniël A. Lionarons, Hannah J. Gould, Andrew J. Beavil, Jenny L. C. Geh, Alastair D. MacKenzie Ross, Ciaran Healy, Eduardo Calonje, Julian Downward, Frank O. Nestle, Sophia Tsoka, Debra H. Josephs, Philip J. Blower, Panagiotis Karagiannis, Katie E. Lacy, James Spicer, Sophia N. Karagiannis, Heather J. Bax
Published 2023-04-01

B cell profiles, antibody repertoire and reactivity reveal dysregulated responses with autoimmune features in melanoma

by Silvia Crescioli, Isabel Correa, Joseph Ng, Zena N. Willsmore, Roman Laddach, Alicia Chenoweth, Jitesh Chauhan, Ashley Di Meo, Alexander Stewart, Eleni Kalliolia, Elena Alberts, Rebecca Adams, Robert J. Harris, Silvia Mele, Giulia Pellizzari, Anna B. M. Black, Heather J. Bax, Anthony Cheung, Mano Nakamura, Ricarda M. Hoffmann, Manuela Terranova-Barberio, Niwa Ali, Ihor Batruch, Antoninus Soosaipillai, Ioannis Prassas, Antigona Ulndreaj, Miyo K. Chatanaka, Rosamund Nuamah, Shichina Kannambath, Pawan Dhami, Jenny L. C. Geh, Alastair D. MacKenzie Ross, Ciaran Healy, Anita Grigoriadis, David Kipling, Panagiotis Karagiannis, Deborah K. Dunn-Walters, Eleftherios P. Diamandis, Sophia Tsoka, James Spicer, Katie E. Lacy, Franca Fraternali, Sophia N. Karagiannis
Published 2023-06-01