Understanding the Spatial Topology of Artificial Immunological Synapses Assembled in T Cell-Redirecting Strategies: A Major Issue in Cancer Immunotherapy

by Pedro Roda-Navarro, Pedro Roda-Navarro, Luis Álvarez-Vallina, Luis Álvarez-Vallina
Published 2020-01-01

Engineered mRNA and the Rise of Next-Generation Antibodies

by Laura Sanz, Luis Álvarez-Vallina
Published 2021-09-01

Engineering Immune Cells for in vivo Secretion of Tumor-Specific T Cell-Redirecting Bispecific Antibodies

by Belén Blanco, Belén Blanco, Ángel Ramírez-Fernández, Ángel Ramírez-Fernández, Luis Alvarez-Vallina, Luis Alvarez-Vallina
Published 2020-08-01

Carcinoembryonic Antigen (CEA)-Specific 4-1BB-Costimulation Induced by CEA-Targeted 4-1BB-Agonistic Trimerbodies

by Kasper Mikkelsen, Seandean Lykke Harwood, Marta Compte, Nekane Merino, Kasper Mølgaard, Simon Lykkemark, Ana Alvarez-Mendez, Francisco J. Blanco, Francisco J. Blanco, Luis Álvarez-Vallina, Luis Álvarez-Vallina, Luis Álvarez-Vallina
Published 2019-07-01

Bi- and trispecific immune cell engagers for immunotherapy of hematological malignancies

by Antonio Tapia-Galisteo, Luis Álvarez-Vallina, Laura Sanz
Published 2023-07-01

Immune regulation by pericytes: modulating innate and adaptive immunity

by Rocio Navarro, Marta Compte, Luis Alvarez-Vallina, Laura Sanz
Published 2016-11-01

In Vivo Secretion of Bispecific Antibodies Recruiting Lymphocytic Effector Cells

by Luis Alvarez-Vallina, Laura Sanz, Natalia Nuñez-Prado, Marta Compte
Published 2013-06-01

Synthetic TILs: Engineered Tumor-Infiltrating Lymphocytes With Improved Therapeutic Potential

by Anaïs Jiménez-Reinoso, Anaïs Jiménez-Reinoso, Daniel Nehme-Álvarez, Daniel Nehme-Álvarez, Carmen Domínguez-Alonso, Carmen Domínguez-Alonso, Luis Álvarez-Vallina, Luis Álvarez-Vallina
Published 2021-02-01

Lymphocyte display: a novel antibody selection platform based on T cell activation.

by Vanesa Alonso-Camino, David Sánchez-Martín, Marta Compte, Laura Sanz, Luis Alvarez-Vallina
Published 2009-09-01

Bispecific Antibody Format and the Organization of Immunological Synapses in T Cell-Redirecting Strategies for Cancer Immunotherapy

by Carlos Carrasco-Padilla, Alicia Hernaiz-Esteban, Luis Álvarez-Vallina, Oscar Aguilar-Sopeña, Pedro Roda-Navarro
Published 2022-12-01

CARbodies: Human Antibodies Against Cell Surface Tumor Antigens Selected From Repertoires Displayed on T Cell Chimeric Antigen Receptors

by Vanesa Alonso-Camino, David Sánchez-Martín, Marta Compte, Natalia Nuñez-Prado, Rosa M Diaz, Richard Vile, Luis Alvarez-Vallina
Published 2013-01-01

Case Report: An EGFR-Targeted 4-1BB-agonistic Trimerbody Does Not Induce Hepatotoxicity in Transgenic Mice With Liver Expression of Human EGFR

by Marta Compte, Seandean L. Harwood, Jorge Martínez-Torrecuadrada, Gema Perez-Chacon, Gema Perez-Chacon, Patricia González-García, Antonio Tapia-Galisteo, Paul M. P. Van Bergen en Henegouwen, Aránzazu Sánchez, Isabel Fabregat, Laura Sanz, Juan M. Zapata, Juan M. Zapata, Luis Alvarez-Vallina, Luis Alvarez-Vallina
Published 2021-01-01

In vivo tumor targeting and imaging with engineered trivalent antibody fragments containing collagen-derived sequences.

by Angel M Cuesta, David Sánchez-Martín, Laura Sanz, Jaume Bonet, Marta Compte, Leonor Kremer, Francisco J Blanco, Baldomero Oliva, Luis Alvarez-Vallina
Published 2009-01-01

Synapse topology and downmodulation events determine the functional outcome of anti-CD19 T cell-redirecting strategies

by Ángel Ramírez-Fernández, Óscar Aguilar-Sopeña, Laura Díez-Alonso, Alejandro Segura-Tudela, Carmen Domínguez-Alonso, Pedro Roda-Navarro, Luis Álvarez-Vallina, Belén Blanco
Published 2022-12-01

P32-specific CAR T cells with dual antitumor and antiangiogenic therapeutic potential in gliomas

by Liat Rousso-Noori, Ignacio Mastandrea, Shauli Talmor, Tova Waks, Anat Globerson Levin, Maarja Haugas, Tambet Teesalu, Luis Alvarez-Vallina, Zelig Eshhar, Dinorah Friedmann-Morvinski
Published 2021-06-01

The heterotrimeric laminin coiled-coil domain exerts anti-adhesive effects and induces a pro-invasive phenotype.

by Patricia Santos-Valle, Irene Guijarro-Muñoz, Angel M Cuesta, Vanesa Alonso-Camino, Maider Villate, Ana Alvarez-Cienfuegos, Francisco J Blanco, Laura Sanz, Luis Alvarez-Vallina
Published 2012-01-01

Programmable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinity

by Ole A. Mandrup, Sui Ching Ong, Simon Lykkemark, Anders Dinesen, Imke Rudnik-Jansen, Niels Frederik Dagnæs-Hansen, Jan Terje Andersen, Luis Alvarez-Vallina, Kenneth A. Howard
Published 2021-03-01

Characterization of a Trispecific PD-L1 Blocking Antibody That Exhibits EGFR-Conditional 4-1BB Agonist Activity

by Laura Rubio-Pérez, Susana Frago, Marta Compte, Rocío Navarro, Seandean L. Harwood, Rodrigo Lázaro-Gorines, Marina Gómez-Rosel, Oana Hangiu, Noelia Silva-Pilipich, Lucía Vanrell, Cristian Smerdou, Luis Álvarez-Vallina
Published 2024-04-01

Combination of T cell-redirecting strategies with a bispecific antibody blocking TGF-β and PD-L1 enhances antitumor responses

by Antonio Tapia-Galisteo, Iñigo Sánchez-Rodríguez, Javier Narbona, Patricia Iglesias-Hernández, Saray Aragón-García, Anaïs Jiménez-Reinoso, Marta Compte, Shaukat Khan, Takeshi Tsuda, Patrick Chames, Javier Lacadena, Luis Álvarez-Vallina, Laura Sanz
Published 2024-12-01

TGF‐β‐induced IGFBP‐3 is a key paracrine factor from activated pericytes that promotes colorectal cancer cell migration and invasion

by Rocío Navarro, Antonio Tapia‐Galisteo, Laura Martín‐García, Carlos Tarín, Cesáreo Corbacho, Gonzalo Gómez‐López, Esther Sánchez‐Tirado, Susana Campuzano, Araceli González‐Cortés, Paloma Yáñez‐Sedeño, Marta Compte, Luis Álvarez‐Vallina, Laura Sanz
Published 2020-10-01