Computational Docking of Antibody-Antigen Complexes, Opportunities and Pitfalls Illustrated by Influenza Hemagglutinin

by Mattia Pedotti, Luca Simonelli, Elsa Livoti, Luca Varani
Published 2011-01-01

Development of a Novel Bioinformatics Tool for In Silico Validation of Protein Interactions

by Nicola Barbarini, Luca Simonelli, Alberto Azzalin, Sergio Comincini, Riccardo Bellazzi
Published 2010-01-01

Rational engineering of the lccβ T. versicolor laccase for the mediator-less oxidation of large polycyclic aromatic hydrocarbons

by Alessandro Chiadò, Francesca Bosco, Marco Bardelli, Luca Simonelli, Mattia Pedotti, Luca Marmo, Luca Varani
Published 2021-01-01

Rational modification of estrogen receptor by combination of computational and experimental analysis.

by Valentina Elisabetta Viviana Ferrero, Mattia Pedotti, Alessandro Chiadò, Luca Simonelli, Luigi Calzolai, Luca Varani, Teresa Lettieri
Published 2014-01-01

Altered Cellular Distribution and Sub-Cellular Sorting of Doppel (Dpl) Protein in Human Astrocytoma Cell Lines

by Elena Sbalchiero, Alberto Azzalin, Silvia Palumbo, Giulia Barbieri, Agustina Arias, Luca Simonelli, Luca Ferretti, Sergio Comincini
Published 2008-01-01

Rational engineering of a human anti-dengue antibody through experimentally validated computational docking.

by Luca Simonelli, Mattia Pedotti, Martina Beltramello, Elsa Livoti, Luigi Calzolai, Federica Sallusto, Antonio Lanzavecchia, Luca Varani
Published 2013-01-01

Analytical Ultracentrifugation Detects Quaternary Rearrangements and Antibody-Induced Conformational Selection of the SARS-CoV-2 Spike Trimer

by Giuditta Guerrini, Dora Mehn, Francesco Fumagalli, Sabrina Gioria, Mattia Pedotti, Luca Simonelli, Filippo Bianchini, Davide F. Robbiani, Luca Varani, Luigi Calzolai
Published 2023-10-01

A bispecific immunotweezer prevents soluble PrP oligomers and abolishes prion toxicity.

by Marco Bardelli, Karl Frontzek, Luca Simonelli, Simone Hornemann, Mattia Pedotti, Federica Mazzola, Manfredi Carta, Valeria Eckhardt, Rocco D'Antuono, Tommaso Virgilio, Santiago F González, Adriano Aguzzi, Luca Varani
Published 2018-10-01

Adapting Neutralizing Antibodies to Viral Variants by Structure‐Guided Affinity Maturation Using Phage Display Technology

by Frederik Peissert, Mattia Pedotti, Riccardo Corbellari, Luca Simonelli, Raoul De Gasparo, Elia Tamagnini, Louis Plüss, Abdullah Elsayed, Mattia Matasci, Roberto De Luca, Irene Cassaniti, Jose’ Camilla Sammartino, Antonio Piralla, Fausto Baldanti, Dario Neri, Luca Varani
Published 2023-10-01

19n01, a broadly neutralizing antibody against omicron BA.1, BA.2, BA.4/5, and other SARS-CoV-2 variants of concern

by Melissa García-Vega, Edgar A. Melgoza-González, Sofía Hernández-Valenzuela, Diana Hinojosa-Trujillo, Mónica Reséndiz-Sandoval, Mara Anais Llamas-Covarrubias, Martín Loza-López, Olivia Valenzuela, Alan Soto-Gaxiola, Miguel A. Hernández-Oñate, Verónica Mata-Haro, Irene Cassaniti, Josè Camilla Sammartino, Alessandro Ferrari, Luca Simonelli, Mattia Pedotti, Rui Sun, Fanglei Zuo, Fausto Baldanti, Luca Varani, Harold Marcotte, Qiang Pan-Hammarström, Jesús Hernández
Published 2023-04-01

Human antibodies in Mexico and Brazil neutralizing tick-borne flaviviruses

by Tomás Cervantes Rincón, Tania Kapoor, Jennifer R. Keeffe, Luca Simonelli, Hans-Heinrich Hoffmann, Marianna Agudelo, Andrea Jurado, Avery Peace, Yu E. Lee, Anna Gazumyan, Francesca Guidetti, Jasmine Cantergiani, Benedetta Cena, Filippo Bianchini, Elia Tamagnini, Simone G. Moro, Pavel Svoboda, Federico Costa, Mitermayer G. Reis, Albert I. Ko, Brian A. Fallon, Santiago Avila-Rios, Gustavo Reyes-Téran, Charles M. Rice, Michel C. Nussenzweig, Pamela J. Bjorkman, Daniel Ruzek, Luca Varani, Margaret R. MacDonald, Davide F. Robbiani
Published 2024-06-01

SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface

by Federico Bertoglio, Doris Meier, Nora Langreder, Stephan Steinke, Ulfert Rand, Luca Simonelli, Philip Alexander Heine, Rico Ballmann, Kai-Thomas Schneider, Kristian Daniel Ralph Roth, Maximilian Ruschig, Peggy Riese, Kathrin Eschke, Yeonsu Kim, Dorina Schäckermann, Mattia Pedotti, Philipp Kuhn, Susanne Zock-Emmenthal, Johannes Wöhrle, Normann Kilb, Tobias Herz, Marlies Becker, Martina Grasshoff, Esther Veronika Wenzel, Giulio Russo, Andrea Kröger, Linda Brunotte, Stephan Ludwig, Viola Fühner, Stefan Daniel Krämer, Stefan Dübel, Luca Varani, Günter Roth, Luka Čičin-Šain, Maren Schubert, Michael Hust
Published 2021-03-01